Visualization of size-dependent tumour retention of PEGylated nanographene oxide via SPECT imaging

2016 ◽  
Vol 4 (39) ◽  
pp. 6446-6453 ◽  
Author(s):  
Tianye Cao ◽  
Peihong You ◽  
Xiaobao Zhou ◽  
Jianmin Luo ◽  
Xiaoping Xu ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Spect Imaging ◽  
Size Dependent ◽  
Tumor Accumulation

Sub-50 nm usNGO–PEG was confirmed to be the favorable size for faster and higher cellular uptake and efficient tumor accumulation than over-50 nm NGO–PEG.

scholarly journals Cerium oxide nanoparticles at the nano-bio interface: size-dependent cellular uptake

2018 ◽  
Vol 46 (sup3) ◽  
pp. S956-S963 ◽  
Author(s):  
Sushant Singh ◽  
Anh Ly ◽  
Soumen Das ◽  
Tamil S. Sakthivel ◽  
Swetha Barkam ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Cellular Uptake ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Size Dependent

scholarly journals Size‐Dependent Cellular Uptake of RGD Peptides

ChemBioChem ◽  
2019 ◽  
Vol 21 (4) ◽  
pp. 496-499 ◽  
Author(s):  
Isabell Kemker ◽  
Rebecca C. Feiner ◽  
Kristian M. Müller ◽  
Norbert Sewald
Keyword(s):  
Cellular Uptake ◽  
Rgd Peptides ◽  
Size Dependent

Elimination of Quantum Dots Cell Uptake

2009 ◽  
Vol 1236 ◽  
Author(s):  
Hengyi Xu ◽  
Zoraida Pascual Aguilar ◽  
Ben Jones ◽  
Hua Wei ◽  
Andrew Wang
Keyword(s):  
Cellular Uptake ◽  
Targeted Delivery ◽  
New Technology ◽  
Binding Activity ◽  
Cell Uptake ◽  
Biological Research ◽  
Size Dependent ◽  
Small Bandwidth ◽  
Specific Uptake ◽  
Surface Modified

AbstractThe nanotechnology is undergoing enormous attention in the areas of biological research for clinical, environmental, and life sciences applications. One of the products from this new technology that attracts researcher’s attentions is the semiconductor quantum dot (QDs) nanoparticles, QDs possess incomparable advantages such as unique size-dependent physical properties, broad absorption spectrum, precise small bandwidth emission wavelength, as well as enhanced chemical and photochemical stability. The QDs can be modified for a controlled and enhanced endocytosis, enhanced cooperative binding activity, and easy introduction of multi-functionalities for medical applications such as targeted delivery and imaging. It can be used for complex studies that play very important roles in the modern biomedical researches. However, when performing the cell related assays, the non-specific cellular uptake of QDs is a major concern because they can lead to false positives or false results. In our study, we used different surface modified QDs treated with different blocking buffers to eliminate cellular uptake. The preliminary results showed that the cellular uptake of QDs can be eliminated by surface modification of the QD materials and by performing the assays in the presence of blocking buffers. As a result of the elimination of non-specific uptake of QDs the sensitivity and specificity of detection increased significantly.

scholarly journals Size-dependent cellular uptake of exosomes

2017 ◽  
Vol 13 (3) ◽  
pp. 1011-1020 ◽  
Author(s):  
Federica Caponnetto ◽  
Ivana Manini ◽  
Miran Skrap ◽  
Timea Palmai-Pallag ◽  
Carla Di Loreto ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Size Dependent

scholarly journals 131I-Labeled Multifunctional Polyethylenimine/Doxorubicin Complexes with pH-Controlled Cellular Uptake Property for Enhanced SPECT Imaging and Chemo/Radiotherapy of Tumors

2021 ◽  
Vol Volume 16 ◽  
pp. 5167-5183
Author(s):  
Jingyi Zhu ◽  
Junxing Yang ◽  
Lingzhou Zhao ◽  
Pingping Zhao ◽  
Jiqin Yang ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Spect Imaging ◽  
Ph Controlled

scholarly journals Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics

Materials ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 513 ◽  
Author(s):  
Francisco Silva ◽  
António Paulo ◽  
Agnès Pallier ◽  
Sandra Même ◽  
Éva Tóth ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cellular Uptake ◽  
Photon Emission ◽  
Spect Imaging ◽  
Emission Computed Tomography ◽  
Bimodal Imaging ◽  
Biodistribution Studies ◽  
T1 And T2 ◽  
T2 Mri

Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNPs carry a bombesin analogue with affinity towards the gastrin releasing peptide receptor (GRPr), overexpressed in a variety of human cancer cells, namely PC3 prostate cancer cells. The potential of these multimodal imaging nanoconstructs was thoroughly investigated by the assessment of their magnetic properties, in vitro cellular uptake, biodistribution, and radiosensitisation assays. The relaxometric properties predict a potential T1- and T2- MRI application. The promising in vitro cellular uptake of 67Ga/Gd-based bombesin containing particles was confirmed through biodistribution studies in tumor bearing mice, indicating their integrity and ability to target the GRPr. Radiosensitization studies revealed the therapeutic potential of the nanoparticles. Moreover, the DOTA chelating unit moiety versatility gives a high theranostic potential through the coordination of other therapeutically interesting radiometals. Altogether, our nanoparticles are interesting nanomaterial for theranostic application and as bimodal T1- and T2- MRI / SPECT imaging probes.

scholarly journals Size-dependent cellular uptake and localization profiles of silver nanoparticles

2019 ◽  
Vol Volume 14 ◽  
pp. 4247-4259 ◽  
Author(s):  
Meiyu Wu ◽  
Hongbo Guo ◽  
Lin Liu ◽  
Ying Liu ◽  
Liming Xie
Keyword(s):  
Silver Nanoparticles ◽  
Cellular Uptake ◽  
Size Dependent

Size Dependent Biodistribution and SPECT Imaging of111In-Labeled Polymersomes

2012 ◽  
Vol 23 (5) ◽  
pp. 958-965 ◽  
Author(s):  
René P. Brinkhuis ◽  
Katica Stojanov ◽  
Peter Laverman ◽  
Jos Eilander ◽  
Inge S. Zuhorn ◽  
...  
Keyword(s):  
Spect Imaging ◽  
Size Dependent
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