Sex Differences in Tobacco Smoking-Induced Upregulation of Beta2-Nicotinic Acetylcholine Receptors: A 5-IA-85380 SPECT Imaging Study

2011 ◽  
Author(s):  
Kelly P. Cosgrove ◽  
Irina Esterlis ◽  
Sherry Mckee ◽  
Frederic Bois ◽  
John Seibyl ◽  
...  
Keyword(s):  
Sex Differences ◽  
Nicotinic Acetylcholine Receptors ◽  
Tobacco Smoking ◽  
Acetylcholine Receptors ◽  
Imaging Study ◽  
Spect Imaging ◽  
Nicotinic Acetylcholine

scholarly journals Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors

2021 ◽  
Vol 15 ◽  
Author(s):  
Janna K. Moen ◽  
Anna M. Lee
Keyword(s):  
Sex Differences ◽  
Sex Hormones ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Future Research ◽  
Preclinical Research ◽  
Receptor System ◽  
Nicotinic Acetylcholine ◽  
The Way ◽  
Reward Behaviors

Alcohol and nicotine are the two most widely used and misused drugs around the world, and co-consumption of both substances is highly prevalent. Multiple lines of evidence show a profound effect of sex in many aspects of alcohol and nicotine reward, with women having more difficulty quitting smoking and showing a faster progression toward developing alcohol use disorder compared with men. Both alcohol and nicotine require neuronal nicotinic acetylcholine receptors (nAChRs) to elicit rewarding effects within the mesolimbic system, representing a shared molecular pathway that likely contributes to the frequent comorbidity of alcohol and nicotine dependence. However, the majority of preclinical studies on the mechanisms of alcohol and nicotine reward behaviors utilize only male rodents, and thus our understanding of alcohol and nicotine neuropharmacology relies heavily on male data. As preclinical research informs the development and refinement of therapies to help patients reduce drug consumption, it is critical to understand the way biological sex and sex hormones influence the rewarding properties of alcohol and nicotine. In this review, we summarize what is known about sex differences in rodent models of alcohol and nicotine reward behaviors with a focus on neuronal nAChRs, highlighting exciting areas for future research. Additionally, we discuss the way circulating sex hormones may interact with neuronal nAChRs to influence reward-related behavior.

scholarly journals SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals

2010 ◽  
Vol 108 (1-2) ◽  
pp. 146-150 ◽  
Author(s):  
Irina Esterlis ◽  
Kelly P. Cosgrove ◽  
Ismene L. Petrakis ◽  
Sherry A. McKee ◽  
Frederic Bois ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Alcohol Drinking ◽  
Acetylcholine Receptors ◽  
Spect Imaging ◽  
Nicotinic Acetylcholine ◽  
Heavy Alcohol

Nicotinic acetylcholine receptors in the patients with Parkinson's disease: 5IA-SPECT

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S586-S586 ◽  
Author(s):  
Kazuo Hashikawa ◽  
Hidefumi Yoshida ◽  
Nobukatsu Sawamoto ◽  
Shigetoshi Takaya ◽  
Chihiro Namiki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine
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