scholarly journals Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy

2018 ◽  
Vol Volume 13 ◽  
pp. 1381-1398 ◽  
Author(s):  
Jiajiang Xie ◽  
Zhongxiong Fan ◽  
Yang Li ◽  
Yinying Zhang ◽  
Fei Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Ph Sensitive ◽  
Curcumin Nanoparticles ◽  
Combination Cancer Therapy ◽  
Dual Drug

Dually folate/CD44 receptor-targeted self-assembled hyaluronic acid nanoparticles for dual-drug delivery and combination cancer therapy

2017 ◽  
Vol 5 (33) ◽  
pp. 6835-6846 ◽  
Author(s):  
Liang Song ◽  
Zhou Pan ◽  
Huabing Zhang ◽  
Yanxiu Li ◽  
Yinying Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Anticancer Effect ◽  
Cd44 Receptor ◽  
Dual Targeting ◽  
Combination Cancer Therapy ◽  
Self Assembled ◽  
Dual Drug

Self-assembled methotrexate-hyaluronic acid-octadecylamine nanoparticles loaded with curcumin have dual-targeting and combinational anticancer effect to folate and CD44 receptors overexpressed cancer cells.

Graft copolymers with tunable amphiphilicity tailored for efficient dual drug delivery via encapsulation and pH-sensitive drug conjugation

2020 ◽  
Vol 11 (27) ◽  
pp. 4438-4453
Author(s):  
Markéta Bláhová ◽  
Eva Randárová ◽  
Rafal Konefał ◽  
Benjamin Nottelet ◽  
Tomáš Etrych
Keyword(s):  
Drug Delivery ◽  
Graft Copolymers ◽  
Ph Sensitive ◽  
Solution Properties ◽  
High Drug ◽  
Drug Conjugation ◽  
Hydroxypropyl Methacrylamide ◽  
Dual Drug

Amphiphilic poly(ε-caprolactone)-graft-(poly-N-(2-hydroxypropyl) methacrylamide) copolymers with tunable solution properties form stable micelles with high drug payload via simultaneous encapsulation and pH-sensitive covalent conjugation.

pH sensitive surfactant-stabilized Fe3O4 magnetic nanocarriers for dual drug delivery

2018 ◽  
Vol 162 ◽  
pp. 163-171 ◽  
Author(s):  
Bijaideep Dutta ◽  
Neena G. Shetake ◽  
B.K. Barick ◽  
K.C. Barick ◽  
B.N. Pandey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Magnetic Nanocarriers ◽  
Dual Drug

Microfluidic conceived pH sensitive core–shell particles for dual drug delivery

2015 ◽  
Vol 478 (1) ◽  
pp. 78-87 ◽  
Author(s):  
Ikram Ullah Khan ◽  
Lukas Stolch ◽  
Christophe A. Serra ◽  
Nicolas Anton ◽  
Roman Akasov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Core Shell ◽  
Shell Particles ◽  
Dual Drug

Enzyme- and pH-Sensitive Branched Polymer–Doxorubicin Conjugate-Based Nanoscale Drug Delivery System for Cancer Therapy

2016 ◽  
Vol 8 (18) ◽  
pp. 11765-11778 ◽  
Author(s):  
Xiaoli Wei ◽  
Qiang Luo ◽  
Ling Sun ◽  
Xue Li ◽  
Hongyan Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Branched Polymer

pH-Sensitive nanogels for drug delivery in cancer therapy

2021 ◽  
Author(s):  
Zhen Li ◽  
Jun Huang ◽  
Jun Wu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Solid Tumors ◽  
Normal Tissue ◽  
Ph Value ◽  
Ph Sensitive ◽  
Ph Gradient

Compared to normal tissue, solid tumors exhibit a lower pH value. Such pH gradient can be used to design pH-sensitive nanogels for selective drug delivery. The acid-sensitive elements in the nanogel cause it to swell/degrade rapidly, followed by rapid drug release.

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