Enzyme- and pH-Sensitive Branched Polymer–Doxorubicin Conjugate-Based Nanoscale Drug Delivery System for Cancer Therapy

2016 ◽  
Vol 8 (18) ◽  
pp. 11765-11778 ◽  
Author(s):  
Xiaoli Wei ◽  
Qiang Luo ◽  
Ling Sun ◽  
Xue Li ◽  
Hongyan Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Branched Polymer

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

scholarly journals In vitro evaluation of a novel pH sensitive drug delivery system based cockle shell-derived aragonite nanoparticles against osteosarcoma

2017 ◽  
Vol 12 (1) ◽  
pp. 166-187 ◽  
Author(s):  
Wenliang Fu ◽  
Mohd Hezmee Mohd Noor ◽  
Loqman Mohamad Yusof ◽  
Tengku Azmi Tengku Ibrahim ◽  
Yeap Swee Keong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
In Vitro Evaluation ◽  
Cockle Shell

New in-situ synthetized hydrogel composite based on alginate and brushite as a potential pH sensitive drug delivery system

2017 ◽  
Vol 177 ◽  
pp. 324-333 ◽  
Author(s):  
Seyed Mohammad Hossein Dabiri ◽  
Alberto Lagazzo ◽  
Fabrizio Barberis ◽  
Amirreza Shayganpour ◽  
Elisabetta Finocchio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Hydrogel Composite

scholarly journals Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study

2018 ◽  
Vol 97 ◽  
pp. 489-495 ◽  
Author(s):  
Liziane O.F. Monteiro ◽  
Renata S. Fernandes ◽  
Caroline M.R. Oda ◽  
Sávia C. Lopes ◽  
Danyelle M. Townsend ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Biodistribution Study ◽  
Potential Drug ◽  
System A

Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficacy

2016 ◽  
Vol 4 (13) ◽  
pp. 2253-2263 ◽  
Author(s):  
Mingxian Liu ◽  
Yanzhou Chang ◽  
Jing Yang ◽  
Yuanyuan You ◽  
Rui He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Halloysite Nanotube ◽  
Anticancer Efficacy

A new HNTs-based drug delivery system to improve the bioavailability of curcumin for cancer therapy is proposed.

Sign in / Sign up

Export Citation Format

Share Document