Dually folate/CD44 receptor-targeted self-assembled hyaluronic acid nanoparticles for dual-drug delivery and combination cancer therapy

2017 ◽  
Vol 5 (33) ◽  
pp. 6835-6846 ◽  
Author(s):  
Liang Song ◽  
Zhou Pan ◽  
Huabing Zhang ◽  
Yanxiu Li ◽  
Yinying Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Anticancer Effect ◽  
Cd44 Receptor ◽  
Dual Targeting ◽  
Combination Cancer Therapy ◽  
Self Assembled ◽  
Dual Drug

Self-assembled methotrexate-hyaluronic acid-octadecylamine nanoparticles loaded with curcumin have dual-targeting and combinational anticancer effect to folate and CD44 receptors overexpressed cancer cells.

scholarly journals Biomedical Applications of Hyaluronic Acid-Based Nanomaterials in Hyperthermic Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 306 ◽  
Author(s):  
Subin Kim ◽  
Myeong ju Moon ◽  
Suchithra Poilil Surendran ◽  
Yong Yeon Jeong
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Biomedical Applications ◽  
Treatment Approach ◽  
Critical Role ◽  
Sulfated Polysaccharide

Hyaluronic acid (HA) is a non-sulfated polysaccharide polymer with the properties of biodegradability, biocompatibility, and non-toxicity. Additionally, HA specifically binds to certain receptors that are over-expressed in cancer cells. To maximize the effect of drug delivery and cancer treatment, diverse types of nanomaterials have been developed. HA-based nanomaterials, including micelles, polymersomes, hydrogels, and nanoparticles, play a critical role in efficient drug delivery and cancer treatment. Hyperthermic cancer treatment using HA-based nanomaterials has attracted attention as an efficient cancer treatment approach. In this paper, the biomedical applications of HA-based nanomaterials in hyperthermic cancer treatment and combined therapies are summarized. HA-based nanomaterials may become a representative platform in hyperthermic cancer treatment.

Hyaluronan based Multifunctional Nano-carriers for Combination Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Menghan Gao ◽  
Hong Deng ◽  
Weiqi Zhang
Keyword(s):  
Cancer Therapy ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Functional Sites ◽  
Therapeutic Modalities ◽  
Combination Cancer Therapy ◽  
Targeting Strategy

: Hyaluronan (HA) is a natural linear polysaccharide that has excellent hydrophilicity, biocompatibility, biodegradability, and low immunogenicity, making it one of the most attractive biopolymers used for biomedical researches and applications. Due to the multiple functional sites on HA and its intrinsic affinity for CD44, a receptor highly expressed on various cancer cells, HA has been widely engineered to construct different drug-loading nanoparticles (NPs) for CD44- targeted anti-tumor therapy. When a cocktail of drugs is co-loaded in HA NP, a multifunctional nano-carriers could be obtained, which features as a highly effective and self-targeting strategy to combat the cancers with CD44 overexpression. The HA-based multidrug nano-carriers can be a combination of different drugs, various therapeutic modalities, or the integration of therapy and diagnostics (theranostics). Up to now, there are many types of HA-based multidrug nano-carriers constructed by different formulation strategies including drug co-conjugates, micelles, nano-gels and hybrid NP of HA and so on. This multidrug nano-carrier takes the full advantages of HA as NP matrix, drug carriers and targeting ligand, representing a simplified and biocompatible platform to realize the targeted and synergistic combination therapy against the cancers. In this review, recent progresses about HA-based multidrug nano-carriers for combination cancer therapy are summarized and its potential challenges for translational applications have been discussed.

Star-Shaped Polylactide Dipyridamole Conjugated to 5-Fluorouracil and 4-Piperidinopiperidine Nanocarriers for Bioimaging and Dual Drug Delivery in Cancer Cells

2021 ◽  
Author(s):  
Dhanya Moorkoth ◽  
Kesavan Madhavan Nampoothiri ◽  
Selvaraj Nagarajan ◽  
Aswathy Ravindran Girija ◽  
Sivakumar Balasubramaniyan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Dual Drug

Photosensitizer-Incorporated Quadruplex DNA-Gated Nanovechicles for Light-Triggered, Targeted Dual Drug Delivery to Cancer Cells

Small ◽  
2013 ◽  
Vol 9 (16) ◽  
pp. 2793-2800 ◽  
Author(s):  
Cuie Chen ◽  
Li Zhou ◽  
Jie Geng ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Quadruplex Dna ◽  
Dual Drug

Dual-targeting SERS-encoded graphene oxide nanocarrier for intracellular co-delivery of doxorubicin and 9-aminoacridine with enhanced combination therapy

The Analyst ◽  
2021 ◽  
Author(s):  
Hui Chen ◽  
Longqiang Xing ◽  
Huiru Guo ◽  
Caixia Luo ◽  
Xuedian Zhang
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Combination Therapy ◽  
Combinational Therapy ◽  
Dual Targeting ◽  
Dual Drug

A multifunctional nanocarrier based on SERS traceable and dual-targeted graphene oxide for the dual-drug delivery with enhanced combinational therapy.

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