scholarly journals Folic acid-conjugated amphiphilic alternating copolymer as a new active tumor targeting drug delivery platform

2016 ◽  
Vol Volume 10 ◽  
pp. 4101-4110 ◽  
Author(s):  
Xia Li ◽  
Myron Szewczuk ◽  
Cecile Malardier-Jugroot
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Alternating Copolymer ◽  
Delivery Platform

scholarly journals Phosphorylcholine oligomer-grafted graphene oxide for tumor-targeting doxorubicin delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41675-41685 ◽  
Author(s):  
Yu Qin ◽  
Changyu Wang ◽  
Yun Jiang ◽  
Tao Liu ◽  
Jianyong Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Doxorubicin Delivery

Phosphorylcholine oligomer-grafted, folic acid-labeled and doxorubicin-loaded graphene oxide was found to be a potential versatile platform for biomarker-directed drug delivery with optimal biocompatibility.

scholarly journals Functionalized Folic Acid-Conjugated Amphiphilic Alternating Copolymer Actively Targets 3D Multicellular Tumour Spheroids and Delivers the Hydrophobic Drug to the Inner Core

Nanomaterials ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 588 ◽  
Author(s):  
Xia Li ◽  
Manpreet Sambi ◽  
Alexandria DeCarlo ◽  
Sergey V. Burov ◽  
Roman Akasov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inner Core ◽  
Hydrophobic Drug ◽  
Alternating Copolymer ◽  
Smart Drug ◽  
Smart Drug Delivery

Engineering of a “smart” drug delivery system to specifically target tumour cells has been at the forefront of cancer research, having been engineered for safer, more efficient and effective use of chemotherapy for the treatment of cancer. However, selective targeting and choosing the right cancer surface biomarker are critical for a targeted treatment to work. Currently, the available delivery systems use a two-dimensional monolayer of cancer cells to test the efficacy of the drug delivery system, but designing a “smart” drug delivery system to be specific for a tumour in vivo and to penetrate the inner core remains a major design challenge. These challenges can be overcome by using a study model that integrates the three-dimensional aspect of a tumour in a culture system. Here, we tested the efficacy of a functionalized folic acid-conjugated amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric acid (DABA) to specifically target and penetrate the inner core of three-dimensional avascular human pancreatic and breast tumour spheroids in culture. The copolymer was quantitatively analyzed for its hydrophobic drug encapsulation efficiency using three different chemical drug structures with different molecular weights. Their release profiles and tumour targeting properties at various concentrations and pH environments were also characterized. Using the anticancer drug curcumin and two standard clinical chemotherapeutic hydrophobic drugs, paclitaxel and 5-fluorouracil, we tested the ability of FA-DABA-SMA nanoparticles to encapsulate the differently sized drugs and deliver them to kill monolayer pancreatic cancer cells using the WST-1 cell proliferation assay. The findings of this study revealed that the functionalized folic acid-conjugated amphiphilic alternating copolymer shows unique properties as an active “smart” tumor-targeting drug delivery system with the ability to internalize hydrophobic drugs and release the chemotherapeutics for effective killing of cancer cells. The novelty of the study is the first to demonstrate a functionalized “smart” drug delivery system encapsulated with a hydrophobic drug effectively targeting and penetrating the inner core of pancreatic and breast cancer spheroids and reducing their volumes in a dose- and time-dependent manner.

Folic acid-modified liposomal drug delivery strategy for tumor targeting of 5-fluorouracil

2018 ◽  
Vol 114 ◽  
pp. 166-174 ◽  
Author(s):  
Eskandar Moghimipour ◽  
Mohsen Rezaei ◽  
Zahra Ramezani ◽  
Maryam Kouchak ◽  
Mohsen Amini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Liposomal Drug ◽  
Delivery Strategy ◽  
Liposomal Drug Delivery

Core–shell nanoparticles as a drug delivery platform for tumor targeting

2018 ◽  
pp. 387-448 ◽  
Author(s):  
Namdev L. Dhas ◽  
Nisith J. Raval ◽  
Ritu R. Kudarha ◽  
Niyati S. Acharya ◽  
Sanjeev R. Acharya
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Delivery Platform ◽  
Core Shell Nanoparticles

scholarly journals Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform

2016 ◽  
Vol 4 (3) ◽  
pp. 511-521 ◽  
Author(s):  
Vitaliy Kapishon ◽  
Stephanie Allison ◽  
Ralph A. Whitney ◽  
Michael F. Cunningham ◽  
Myron R. Szewczuk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Radical Polymerization ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Living Radical Polymerization ◽  
Delivery Platform

Synthetic steps and subsequent preparation of oseltamivir-conjugated micelles capable of targeting and triggering receptor-induced endocytosis in cancer cells.

scholarly journals Albumin-assisted exfoliated ultrathin rhenium disulfide nanosheets as a tumor targeting and dual-stimuli-responsive drug delivery system for a combination chemo-photothermal treatment

RSC Advances ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 4624-4633 ◽  
Author(s):  
Qunlian Huang ◽  
Shurong Wang ◽  
Jie Zhou ◽  
Xiaoyan Zhong ◽  
Yilan Huang
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Stimuli Responsive ◽  
Photothermal Treatment

The resveratrol and folic acid loaded ultrathin rhenium disulfide nanosheet (utReS2@RSV–FA) could be used as a dual-stimuli-responsive drug delivery system and could effectively be used in a combination chemo-photothermal cancer treatment.

scholarly journals Fabrication and characterization of a folic acid-bound 5-fluorouracil loaded quantum dot system for hepatocellular carcinoma targeted therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (35) ◽  
pp. 19868-19878 ◽  
Author(s):  
Xiaoxin Shi ◽  
Dongxiu He ◽  
Guotao Tang ◽  
Qian Tang ◽  
Runde Xiong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Quantum Dots ◽  
Acetic Acid ◽  
Folic Acid ◽  
Targeted Therapy ◽  
Quantum Dot ◽  
Tumor Targeting ◽  
Fabrication And Characterization

In the present study, we covalently coupled folic acid (FA) and 5-fluorouracil acetic acid (FUA) on the surface of quantum dots (QDs) to produce a tumor targeting drug delivery system, FA-QDs-FUA.

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