scholarly journals Phosphorylcholine oligomer-grafted graphene oxide for tumor-targeting doxorubicin delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41675-41685 ◽  
Author(s):  
Yu Qin ◽  
Changyu Wang ◽  
Yun Jiang ◽  
Tao Liu ◽  
Jianyong Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Doxorubicin Delivery

Phosphorylcholine oligomer-grafted, folic acid-labeled and doxorubicin-loaded graphene oxide was found to be a potential versatile platform for biomarker-directed drug delivery with optimal biocompatibility.

Preparation and anti-cancer activity of transferrin/folic acid double-targeted graphene oxide drug delivery system

2020 ◽  
Vol 35 (1) ◽  
pp. 15-27 ◽  
Author(s):  
Taicheng Lu ◽  
Zhenzhen Nong ◽  
Liying Wei ◽  
Mei Wei ◽  
Guo Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Target Drug Delivery System

In this study, a transferrin/folic acid double-targeting graphene oxide drug delivery system loaded with doxorubicin was designed. Graphene oxide was prepared by ultrasound improved Hummers method and was modified with Pluronic F68, folic acid, and transferrin to decrease its toxicity and to allow dual-targeting. The results show that the double target drug delivery system (TFGP*DOX) has good and controllable drug delivery performance with no toxicity. Moreover, TFGP*DOX has a better inhibitory effect on SMMC-7721 cells than does a single target drug delivery system (FGP*DOX). The results of drug release analysis and cell inhibition studies showed that TFGP*DOX has a good sustained release function that can reduce the drug release rate in blood circulation over time and improve the local drug concentration in or near a targeted tumor. Therefore, the drug loading system (TFGP*DOX) has potential application value in the treatment of hepatocellular carcinoma.

A tumor-targeting drug delivery system based on cyclic NGR-modified, combretastatin A4-loaded, functionalized graphene oxide nanosheets

RSC Advances ◽  
2016 ◽  
Vol 6 (72) ◽  
pp. 68134-68140 ◽  
Author(s):  
Fang Ding ◽  
Fanhong Wu ◽  
Qingqing Tian ◽  
Lingling Guo ◽  
Jing Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Functionalized Graphene ◽  
Graphene Oxide Nanosheets ◽  
Functionalized Graphene Oxide ◽  
Combretastatin A4

Graphene oxide has shown great potential in drug delivery.

scholarly journals Morphological Changes and Cellular Uptake of Functionalized Graphene Oxide Loaded with Protocatechuic Acid and Folic Acid in Hepatocellular Carcinoma Cancer Cell

2020 ◽  
Vol 21 (16) ◽  
pp. 5874
Author(s):  
Kalaivani Buskaran ◽  
Mohd Zobir Hussein ◽  
Mohamad Aris Mohd Moklas ◽  
Sharida Fakurazi
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Cellular Uptake ◽  
Protocatechuic Acid ◽  
Morphological Changes ◽  
Intracellular Uptake ◽  
Functionalized Graphene ◽  
Migration Ability ◽  
Functionalized Graphene Oxide

The development of nanocomposites has swiftly changed the horizon of drug delivery systems in defining a new platform. Major understanding of the interaction of nanocomposites with cells and how the interaction influences intracellular uptake is an important aspect to study in order to ensure successful utilisation of the nanocomposites. Studies have suggested that the nanocomposites’ ability to permeate into biological cells is attributable to their well-defined physicochemical properties with nanoscale size, which is relevant to the nanoscale components of biology and cellular organelles. The functionalized graphene oxide coated with polyethylene glycol, loaded with protocatechuic acid and folic acid (GOP-PCA-FA) nanocomposite intracellular uptake was analysed using transmission electron microscope. The accumulation of fluorescent-labelled nanocomposites in the HepG2 cell was also analysed using a fluorescent microscope. In vitro cellular uptake showed that there was uptake of the drug from 24 h into the cells and the release study using fluorescently tagged nanocomposite demonstrated that release and accumulation were observed at 24 h and 48 h. Moreover, the migration ability of tumor cells is a key step in tumor progression which was observed 48 h after treatment. The GOP serves as a potential nanocarrier system which is capable of improving the therapeutic efficacy of drugs and biomolecules in medical as well as pharmaceutical applications through the enhanced intracellular release and accumulation of the encapsulated drugs. Nonetheless, it is essential to analyse the translocation of our newly developed GOP-PCA-FA, and its efficiency for drug delivery, effective cellular uptake, and abundant intracellular accumulation would be compromised by possible untoward side effects.

Folic acid-modified liposomal drug delivery strategy for tumor targeting of 5-fluorouracil

2018 ◽  
Vol 114 ◽  
pp. 166-174 ◽  
Author(s):  
Eskandar Moghimipour ◽  
Mohsen Rezaei ◽  
Zahra Ramezani ◽  
Maryam Kouchak ◽  
Mohsen Amini ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Liposomal Drug ◽  
Delivery Strategy ◽  
Liposomal Drug Delivery

Tumor targeting dual stimuli responsive controllable release nanoplatform based on DNA-conjugated reduced graphene oxide for chemo-photothermal synergetic cancer therapy

2018 ◽  
Vol 6 (26) ◽  
pp. 4360-4367 ◽  
Author(s):  
Wenjing Jiang ◽  
Fan Mo ◽  
Yaohui Lin ◽  
Xusheng Wang ◽  
LiangJun Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Reduced Graphene Oxide ◽  
Tumor Targeting ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Reduced Graphene ◽  
Controllable Release

A tumor targeting dual stimuli responsive controllable release drug delivery nanoplatform was fabricated for chemo-photothermal synergetic cancer therapy based on DNA-conjugated reduced graphene oxide.

Sign in / Sign up

Export Citation Format

Share Document