scholarly journals Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles

2017 ◽  
Vol Volume 12 ◽  
pp. 2279-2292 ◽  
Author(s):  
Jifu Hao ◽  
Tiantian Tong ◽  
Kai Jin ◽  
Qiannan Zhuang ◽  
Te Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Polyethylene Glycol ◽  
Mixed Micelles ◽  
Polyethylene Glycol 1000 ◽  
Delivery Platform

scholarly journals In VitroCharacterization of Pluronic F127 and D--Tocopheryl Polyethylene Glycol 1000 Succinate Mixed Micelles as Nanocarriers for Targeted Anticancer-Drug Delivery

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Adeel Masood Butt ◽  
Mohd Cairul Iqbal Mohd Amin ◽  
Haliza Katas ◽  
Narong Sarisuta ◽  
Wasu Witoonsaridsilp ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Mixed Micelles ◽  
Chemotherapeutic Agents ◽  
Pluronic F127 ◽  
Breast Adenocarcinoma ◽  
Anticancer Drug Delivery ◽  
Polyethylene Glycol 1000

Mixed micelles of Pluronic F127 andD-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) in different molar ratios (10 : 0, 7 : 3, 5 : 5, and 3 : 7) were prepared to characterize this system as nanocarriers for targeted delivery of chemotherapeutic agents. Their size, zeta potential, critical micelle concentration, drug loading content, entrapment efficiency, drug release, cytotoxicity, and stability in serum were evaluatedin vitroby using doxorubicin as the model anticancer drug. The micellar sizes ranged from 25 to 35 nm. The 7 : 3 and 5 : 5 micellar combinations had lower critical micelle concentrations ( M) than the 10 : 0 combination ( M). The entrapment efficiencies of the 7 : 3, 5 : 5, and 3 : 7 micellar combinations were 72%, 88%, and 69%, respectively. Doxorubicin release was greater at acidic tumour pH than at normal physiological pH. The doxorubicin-loaded mixed micelles showed greater percent inhibition and apoptosis activity in human breast adenocarcinoma (MCF-7) and acute monocytic leukaemia (THP-1) cell lines than free doxorubicin did. The mixed micelles were also stable against aggregation and precipitation in serum. These findings suggest that Pluronic F127-TPGS mixed micelles could be used as nanocarriers for targeted anticancer-drug delivery.

Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles

2013 ◽  
Vol 235 ◽  
pp. 437-442 ◽  
Author(s):  
G. Devanand Venkatasubbu ◽  
S. Ramasamy ◽  
G.S. Avadhani ◽  
V. Ramakrishnan ◽  
J. Kumar
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Folic Acid ◽  
Polyethylene Glycol ◽  
Hydroxyapatite Nanoparticles
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