scholarly journals Fabrication and characterization of a folic acid-bound 5-fluorouracil loaded quantum dot system for hepatocellular carcinoma targeted therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (35) ◽  
pp. 19868-19878 ◽  
Author(s):  
Xiaoxin Shi ◽  
Dongxiu He ◽  
Guotao Tang ◽  
Qian Tang ◽  
Runde Xiong ◽  
...  

In the present study, we covalently coupled folic acid (FA) and 5-fluorouracil acetic acid (FUA) on the surface of quantum dots (QDs) to produce a tumor targeting drug delivery system, FA-QDs-FUA.

2020 ◽  
Author(s):  
Rishibrind Kumar Upadhyay ◽  
Abhinav Pratap Singh ◽  
Deepchandra Upadhyay ◽  
Amit Kumar ◽  
Satyabrata Jit

2014 ◽  
Vol 105 (11) ◽  
pp. 113110 ◽  
Author(s):  
Ko Yamada ◽  
Tetsuo Kodera ◽  
Tomohiro Kambara ◽  
Shunri Oda

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41675-41685 ◽  
Author(s):  
Yu Qin ◽  
Changyu Wang ◽  
Yun Jiang ◽  
Tao Liu ◽  
Jianyong Yang ◽  
...  

Phosphorylcholine oligomer-grafted, folic acid-labeled and doxorubicin-loaded graphene oxide was found to be a potential versatile platform for biomarker-directed drug delivery with optimal biocompatibility.


2012 ◽  
Vol 209 (6) ◽  
pp. 1163-1167 ◽  
Author(s):  
Huu Tuan Nguyen ◽  
Thu Nga Pham ◽  
Ken Ha Koh ◽  
Soonil Lee

2018 ◽  
Vol 8 (4) ◽  
pp. 604 ◽  
Author(s):  
Kyong-Hoon Choi ◽  
Sang-Hyub Moon ◽  
Su-Kang Park ◽  
Guangsup Cho ◽  
Ki Nam ◽  
...  

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2011-2025 ◽  
Author(s):  
Zhen Li ◽  
Jialong Fan ◽  
Chunyi Tong ◽  
Hongyan Zhou ◽  
Wenmiao Wang ◽  
...  

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.


2000 ◽  
Vol 108 (1254) ◽  
pp. 196-201 ◽  
Author(s):  
Tatsuya SHIRAKAMI ◽  
Takahiko NAKAOKI ◽  
Hideki OHMOTO ◽  
Atsushi KISHIGAMI ◽  
Kazuyori URABE

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