COVID-19-Associated Hyperviscosity: A Potential Link between Inflammation and Thrombophilia

2020 ◽  
Author(s):  
Cheryl Maier ◽  
Alex Truong ◽  
Sara Auld ◽  
Derek Polly ◽  
Christin-Lauren Tanksley ◽  
...  
Keyword(s):  
Potential Link

Statistical Analysis of the Relationship Between Antioxidant Activity and the Structure of Flavonoid Compounds

2019 ◽  
Vol 70 (9) ◽  
pp. 3103-3107 ◽  
Author(s):  
Ioana Glevitzky ◽  
Gabriela Alina Dumitrel ◽  
Mirel Glevitzky ◽  
Bianca Pasca ◽  
Pavel Otrisal ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Basic Structure ◽  
Oh Groups ◽  
Flavonoid Compounds ◽  
Chi Squared ◽  
Potential Link ◽  
Van Der Waals Surface ◽  
The Relationship ◽  
Phenolic Oh Groups

Using different methods of statistics, this paper aims to highlight the potential link between the antioxidant activity of flavonoids and the corresponding molecular descriptors. By calculating the descriptors (van der Waals surface (A), molar volume (V), partition coefficient (LogP), refractivity (R), polarizability (a), forming heat (Hformation), hydration energy (Ehidr), the dipole moment (mt)), together with antioxidant activities (RSA) calculated or taken from the literature, number of phenolic -OH groups and the presence (2) or absence (1) of C2=C3 double bond) for 29 flavonoid compounds and by intercorrelation between the studied parameters, the link between the number of phenolic groups grafted to the basic structure of flavonoids and their antioxidant activity was confirmed. Simultaneously, by using the chi-squared test and the intercorrelations matrix, a satisfactorily correlation coefficient (r2=0.5678; r=0.7536) between the structure of the flavonoids and their activity was obtained, fact that confirms the correlation of the antioxidant activity with the number of -OH phenolic groups.

Membrane Damage Induced by Amyloid Beta and a Potential Link with Neuroinflammation

2016 ◽  
Vol 22 (10) ◽  
pp. 1295-1304 ◽  
Author(s):  
Eduardo J. Fernandez-Perez ◽  
Christian Peters ◽  
Luis G. Aguayo
Keyword(s):  
Amyloid Beta ◽  
Membrane Damage ◽  
Potential Link

COVID-19 and Comorbidities: is Inflammation the Underlying Condition in Children? A narrative Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Giulia Pinna ◽  
Lavinia Sanfilippo ◽  
Pier Paolo Bassareo ◽  
Vassilios Fanos ◽  
Maria Antonietta Marcialis
Keyword(s):  
Risk Factor ◽  
Severe Form ◽  
Narrative Review ◽  
Underlying Condition ◽  
Pathogenic Mechanisms ◽  
Associated Diseases ◽  
Potential Link

: This paper examines the potential link between COVID-19 and the presence of comorbidities and assesses the role of inflammation in this correlation. In COVID-19 patients, the most frequently associated diseases share a pathogenic inflammatory basis and apparently act as a risk factor in the onset of a more severe form of the disease, particularly in adulthood. However, in children, the understanding of the underlying pathogenic mechanisms is often complicated by the milder symptoms presented. A series of theories have therefore been put forward with a view of providing a better understanding of the role played by inflammation in this dramatic setting. All evidence available to date on this topic is discussed in this review.

Critical Analysis of the TPRM

2018 ◽  
Author(s):  
Mathias Kende
Keyword(s):  
Peer Review ◽  
Critical Analysis ◽  
Historical Development ◽  
Conceptual Development ◽  
Dispute Settlement ◽  
Participation Rates ◽  
Core Elements ◽  
Potential Link ◽  
International Trading ◽  
Naming And Shaming

This chapter covers the historical development of the WTO’s mechanism for peer review. It examines the conceptual development of peer review and distils typical core elements (objectives, structure, and participants) by looking at the IMF, the OECD, the FSB, the APRM, the UPR, and the UNFCCC and its Kyoto Protocol. These elements are then applied to analyse the historical advent of the TPRM. The analysis also covers the first five appraisals of the TPRM (1999, 2005, 2008, 2011, and 2013). For each of these, it examines the TPRM’s objectives (including its implementation of the naming and shaming objective and potential link(s) with the Dispute Settlement Body), its structure (focusing on individual reviews and on the yearly overviews of developments in the international trading environment), and on its participants (focusing on governmental attendance and participation rates, the evolving capacities of the WTO secretariat, and on the attitudes of discussants).

scholarly journals P496Remodeling of atrial action potential duration and atrial chamber deformation: a potential link in the development of atrial fibrillation?

2018 ◽  
Vol 114 (suppl_1) ◽  
pp. S120-S120
Author(s):  
L Sartiani ◽  
L Sartiani ◽  
M Cameli ◽  
L Dini ◽  
S Modillo ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Action Potential ◽  
Action Potential Duration ◽  
Potential Link

scholarly journals Analysis of Personality Traits in Patients with Hodgkin Lymphoma

2021 ◽  
Vol 10 (8) ◽  
pp. 1631
Author(s):  
Fatima Roso-Bas ◽  
Maria Dolores Alonso-Llobregat ◽  
Leyre Bento ◽  
Blanca Sanchez-Gonzalez ◽  
Ines Herraez ◽  
...  
Keyword(s):  
Personality Traits ◽  
Hodgkin Lymphoma ◽  
Mental Illnesses ◽  
Response To Treatment ◽  
Personality Profiles ◽  
University Hospitals ◽  
Distribution Width ◽  
Potential Link ◽  
Proinflammatory Activity ◽  
Neo Five Factor Inventory

Hodgkin lymphoma (HL) is a highly-curable malignancy mostly affecting young people. As far as we know, there is no published study that has analyzed personality profiles in HL nor their potential role in lymphomagenesis, natural history, or response to treatment. We aim to explore the personality traits of HL patients, as well as the prevalence of mental disorders and suicide ideas. We retrospectively identified all alive HL patients from three centers (Son Espases and Son Llatzer University Hospitals and Hospital del Mar of Barcelona) for using NEO Five-Factor Inventory (NEO-FFI) and Personality Inventory for DSM-5 Brief Form. Patients with HL showed significantly higher neuroticism scores and lower conscientiousness, extraversion, and openness. Considering maladaptive personality traits, HL patients showed higher levels of detachment and psychoticism. All of these translated into the fact that HL patients showed more than double the prevalence of mental illnesses (41%) and more than triple the prevalence of suicidal ideation or attempts than the general population (15 and 6%, respectively). An exploratory analysis of biomarkers associated with HL personality traits showed that higher scores of neuroticism correlated with more elevated erythrocyte sedimentation rate (ESR) and red cell distribution width (RDW), suggesting a potential link between neuroticism and proinflammatory activity in HL.

scholarly journals Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota

2021 ◽  
Vol 12 (2) ◽  
pp. 491-502
Author(s):  
Sarah R. Bloor ◽  
Rudolph Schutte ◽  
Anthony R. Hobson
Keyword(s):  
Side Effects ◽  
Gut Microbiota ◽  
Iron Supplementation ◽  
Methanogenic Archaea ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Intestinal Lumen ◽  
Gastrointestinal Side Effects ◽  
Potential Link ◽  
The Impact

Iron deficiency anaemia (IDA) is a worldwide healthcare problem affecting approximately 25% of the global population. The most common IDA treatment is oral iron supplementation, which has been associated with gastrointestinal (GI) side effects such as constipation and bloating. These can result in treatment non-adherence and the persistence of IDA. Intravenous iron does not cause GI side effects, which may be due to the lack of exposure to the intestinal lumen. Luminal iron can cause changes to the gut microbiota, aiding the promotion of pathogenic species and decreasing beneficial protective species. Iron is vital for methanogenic archaea, which rely on iron for growth and metabolism. Increased intestinal methane has been associated with slowing of intestinal transit, constipation, and bloating. Here we explore the literature to understand a potential link between iron and methanogenesis as a novel way to understand the mechanism of oral iron supplementation induced GI side effects.

Association between E-cigarette use and chronic obstructive pulmonary disease in non-asthmatic adults in the USA

2020 ◽  
Author(s):  
Godfred O Antwi ◽  
Darson L Rhodes
Keyword(s):  
Sex Education ◽  
Smoking Status ◽  
Secondary Data ◽  
Chronic Obstructive ◽  
Behavioral Risk ◽  
Cigarette Use ◽  
Obstructive Pulmonary Disease ◽  
The Usa ◽  
Potential Link ◽  
Using Data

Abstract Background Concern about the health impacts of e-cigarette use is growing; however, limited research exists regarding potential long-term health effects of this behavior. This study explored the relationship between e-cigarette use and COPD in a sample of US adults. Methods A secondary data analysis using data from the 2018 Behavioral Risk Factor Surveillance Survey in the USA was computed to examine associations between e-cigarette use and COPD controlling for conventional cigarette smoking status, past month leisure physical activity and demographic characteristics including age, sex, education, race, marital status and body mass index. Results Significant associations between e-cigarette use and COPD among former combustible cigarette smokers and those who reported never using combustible cigarettes were found. Compared with never e-cigarette users, the odds of having COPD were significantly greater for daily e-cigarette users (OR = 1.53; 95% CI: 1.11–2.03), occasional users (OR = 1.43, 95% CI: 1.13–1.80) and former users (OR = 1.46 95% CI: 1.28–1.67). Conclusions Findings from this study indicate a potential link between e-cigarette use and COPD. Further research to explore the potential effects of e-cigarette on COPD is recommended.

scholarly journals Coaggregation of Asthma and Type 1 Diabetes in Children: A Narrative Review

2021 ◽  
Vol 22 (11) ◽  
pp. 5757
Author(s):  
Laura Sgrazzutti ◽  
Francesco Sansone ◽  
Marina Attanasi ◽  
Sabrina Di Pillo ◽  
Francesco Chiarelli
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Molecular Mechanisms ◽  
Narrative Review ◽  
T Helper ◽  
Children With Asthma ◽  
Potential Link ◽  
Th 1 ◽  
Th1 And Th2

Asthma and type 1 diabetes mellitus (T1DM) are two of the most frequent chronic diseases in children, representing a model of the atopic and autoimmune diseases respectively. These two groups of disorders are mediated by different immunological pathways, T helper (Th)1 for diabetes and Th2 for asthma. For many years, these two groups were thought to be mutually exclusive according to the Th1/Th2 paradigm. In children, the incidence of both diseases is steadily increasing worldwide. In this narrative review, we report the evidence of the potential link between asthma and T1DM in childhood. We discuss which molecular mechanisms could be involved in the link between asthma and T1DM, such as genetic predisposition, cytokine patterns, and environmental influences. Cytokine profile of children with asthma and T1DM shows an activation of both Th1 and Th2 pathways, suggesting a complex genetic-epigenetic interaction. In conclusion, in children, the potential link between asthma and T1DM needs further investigation to improve the diagnostic and therapeutic approach to these patients. The aim of this review is to invite the pediatricians to consider the potential copresence of these two disorders in clinical practice.

Nationwide Outbreak of Red Eye Syndrome Associated With Transfusion of Leukocyte-Reduced Red Blood Cell Units

2006 ◽  
Vol 27 (11) ◽  
pp. 1146-1152 ◽  
Author(s):  
Juan Alonso-Echanove ◽  
Brian D. Sippy ◽  
Arthur E. Chin ◽  
Lisa Cairns ◽  
Rebecca Haley ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Cellulose Acetate ◽  
Blood Cells ◽  
Animal Experiments ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Filter Membrane ◽  
Eye Pain ◽  
Red Eye ◽  
Potential Link

Objective.To characterize red eye reactions occurring within 24 hours after receipt of units of leukocyte-reduced red blood cells, determine their etiology, and investigate their potential link to transfusion.Methods.We conducted a survey of transfusion facilities nationwide to determine the scope and magnitude of the reactions; performed case-control and cohort studies among transfused patients at the facility where most reactions occurred; and performed animal experiments, using cellulose acetate derivatives extracted from leukocyte-reduction filters and filter precursors, to reproduce reactions.Results.From January 1, 1997, through January 15, 1998, we identified 159 reactions in 117 patients from 17 states. Reactions were characterized by conjunctival erythema or hemorrhage (in 100% of patients), eye pain (in 62%), photophobia (in 46%), and decreased visual acuity (in 32%). Symptom onset occurred 1-24 hours after initiation of transfusion and resolved within a median of 5 days. Reactions were associated with transfusion sessions that included units of red blood cells filtered with a specific brand of filter, the LeukoNet filter (HemaSure) (odds ratio, 100.4;P< .001). There was a dose-response relationship between the number of LeukoNet-filtered units transfused and the attack rate for reactions, ranging from 0.8% among sessions in which 1 unit was transfused to 27.3% among sessions in which 3 or more units were transfused (P< .001). A similar ocular syndrome was elicited in rabbits injected with cellulose acetate derivatives extracted from unused LeukoNet filters or filter precursors. No reactions were reported after LeukoNet filters were withdrawn from the market.Conclusions.This transfusion-associated red eye syndrome was linked to a specific brand of leukocyte-reduction filter and likely resulted from cellulose acetate derivatives leached from the filter membrane.

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