Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (2): Blood or plasma concentration, distribution, metabolism, excretion and accumulation in rats after repeated intravenous administration.

Seiu IIDA; Masato IWAMOTO; Masayuki SUZUKI; Noriko HISANAGA; Teiko KOMATSU

doi:10.2133/dmpk.3.331

Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (2): Blood or plasma concentration, distribution, metabolism, excretion and accumulation in rats after repeated intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.331 ◽

1988 ◽

Vol 3 (3) ◽

pp. 331-347

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Teiko KOMATSU

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen

Download Full-text

Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (1): Blood or plasma concentration, distribution, metabolism and excretion in rats after single intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.309 ◽

1988 ◽

Vol 3 (3) ◽

pp. 309-329 ◽

Cited By ~ 1

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Naoki TSUJII ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen ◽

Single Intravenous Administration

Download Full-text

Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (2): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration of 125I-E6010.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.585 ◽

1996 ◽

Vol 11 (6) ◽

pp. 585-598

Author(s):

Hitoshi Mizuo ◽

Kiyomi KIKUCHI ◽

Mannen MISHIMA ◽

Masataka UEDA ◽

Teruaki YUZURIHA

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Type Plasminogen Activator

Download Full-text

Studies on the Metabolic Fate of Modified Recombinant Tissue-Type Plasminogen Activator (E6010) (1): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after a Single Intravenous Administration of l25I-E6010 in Comparison with l25I-Recombinant Tissue-Type Plasminogen Activator (rt-PA).

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.556 ◽

1996 ◽

Vol 11 (6) ◽

pp. 556-584

Author(s):

Hitoshi Mizuo ◽

Takayuki SEKO ◽

Koichi NOSE ◽

Tomomi ANDO ◽

Yoshiko KAGEI ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Tissue Type ◽

Metabolic Fate ◽

Tissue Type Plasminogen Activator ◽

Type Plasminogen Activator ◽

Single Intravenous Administration

Download Full-text

Novel biomimetic affinity ligands for human tissue plasminogen activator

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2007.02.007 ◽

2007 ◽

Vol 355 (3) ◽

pp. 673-678 ◽

Cited By ~ 9

Author(s):

Fang Wu ◽

Jing Yu

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Affinity Ligands ◽

Tissue Plasminogen

Download Full-text

A polymorphic dinucleotide repeat in intron 1 of the human tissue plasminogen activator gene

Human Molecular Genetics ◽

10.1093/hmg/1.2.138-a ◽

1992 ◽

Vol 1 (2) ◽

pp. 138-138 ◽

Cited By ~ 2

Author(s):

W. Thomas ◽

D. Drayna

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Dinucleotide Repeat ◽

Intron 1 ◽

Polymorphic Dinucleotide Repeat ◽

Tissue Plasminogen ◽

Polymorphic Dinucleotide

Download Full-text

In silico and in vivo analyses of the mutated human tissue plasminogen activator (mtPA) and the antithetical effects of P19 silencing suppressor on its expression in two Nicotiana species

Scientific Reports ◽

10.1038/s41598-018-32099-6 ◽

2018 ◽

Vol 8 (1) ◽

Author(s):

Mahshid Amiri ◽

Mokhtar Jalali-Javaran ◽

Raheem Haddad ◽

Parastoo Ehsani

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

In Silico ◽

Silencing Suppressor ◽

Nicotiana Species ◽

Tissue Plasminogen

Download Full-text

Retroviral Vector-Mediated Transfer and Expression of Human Tissue Plasminogen Activator cDNA in Bovine Brain Endothelial Cells

Neurosurgery ◽

10.1097/00006123-199910000-00072 ◽

1999 ◽

Vol 45 (4) ◽

pp. 962-970 ◽

Cited By ~ 7

Author(s):

Hong Yu ◽

Ying Wang ◽

Darwin Eton ◽

Monique Stins ◽

Liang Wang ◽

...

Keyword(s):

Endothelial Cells ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Retroviral Vector ◽

Bovine Brain ◽

Brain Endothelial Cells ◽

Tissue Plasminogen

Download Full-text

Intracranial hemorrhage after intravenous administration of tissue plasminogen activator in a patient with acute ischemic stroke: case report

Nosotchu ◽

10.3995/jstroke.10567 ◽

2019 ◽

Vol 41 (2) ◽

pp. 106-110

Author(s):

Yasufumi Inaka ◽

Kenichiro Ono ◽

Hiroaki Kobayashi ◽

Takashi Takahara ◽

Hidenori Okawa ◽

...

Keyword(s):

Ischemic Stroke ◽

Case Report ◽

Acute Ischemic Stroke ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intracranial Hemorrhage ◽

Intravenous Administration ◽

Tissue Plasminogen ◽

Stroke Case

Download Full-text

Metabolic Fate of YM866, a Novel Fibrinolytic Agent (II). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.11 ◽

1996 ◽

Vol 11 (1) ◽

pp. 11-29

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Saburo HIGUCHI ◽

Satoshi KUROSAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent

Download Full-text

Early Recanalization After Intravenous Administration of Recombinant Tissue Plasminogen Activator as Assessed by Pre- and Post-Thrombolytic Angiography in Acute Ischemic Stroke Patients

Stroke ◽

10.1161/01.str.0000251788.03914.00 ◽

2007 ◽

Vol 38 (1) ◽

pp. 192-193 ◽

Cited By ~ 120

Author(s):

Kyung-Yul Lee ◽

Sang Won Han ◽

Seo Hyun Kim ◽

Hyo Seok Nam ◽

Sung Whan Ahn ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Recombinant Tissue Plasminogen Activator ◽

Stroke Patients ◽

Tissue Plasminogen

Download Full-text