Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (II). Plasma Concentration, Distribution and Excretion after Repeated Intravenous Administration to 7-week Old Rats and after Single Intravenous Administration to 30-week Old Rats, and Transfer into the Fetus and Milk in Rats.

Tsutomu MOCHIZUKI; Shin-ichi NISHIMURA; Koichiro OKABE; Yoshiaki AZUMA; Shin UMEDA; Satoshi KUDOH; Noriko HARAKAWA; Shigeyuki ISHII; Tomohiro OHTA; Shiro KONDO; Mamoru KIYOKI

doi:10.2133/dmpk.10.174

Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (II). Plasma Concentration, Distribution and Excretion after Repeated Intravenous Administration to 7-week Old Rats and after Single Intravenous Administration to 30-week Old Rats, and Transfer into the Fetus and Milk in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.174 ◽

1995 ◽

Vol 10 (2) ◽

pp. 174-189 ◽

Cited By ~ 3

Author(s):

Tsutomu MOCHIZUKI ◽

Shin-ichi NISHIMURA ◽

Koichiro OKABE ◽

Yoshiaki AZUMA ◽

Shin UMEDA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Old Rats ◽

Single Intravenous Administration

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Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (1): Blood or plasma concentration, distribution, metabolism and excretion in rats after single intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.309 ◽

1988 ◽

Vol 3 (3) ◽

pp. 309-329 ◽

Cited By ~ 1

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Naoki TSUJII ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen ◽

Single Intravenous Administration

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Metabolic Fate of YM866, a Novel Fibrinolytic Agent (I). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Single Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.1 ◽

1996 ◽

Vol 11 (1) ◽

pp. 1-10

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Ikuo MIYAMOTO ◽

Saburo HIGUCHI

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Modified Recombinant Tissue-Type Plasminogen Activator (E6010) (1): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after a Single Intravenous Administration of l25I-E6010 in Comparison with l25I-Recombinant Tissue-Type Plasminogen Activator (rt-PA).

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.556 ◽

1996 ◽

Vol 11 (6) ◽

pp. 556-584

Author(s):

Hitoshi Mizuo ◽

Takayuki SEKO ◽

Koichi NOSE ◽

Tomomi ANDO ◽

Yoshiko KAGEI ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Tissue Type ◽

Metabolic Fate ◽

Tissue Type Plasminogen Activator ◽

Type Plasminogen Activator ◽

Single Intravenous Administration

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Metabolic Fate of YM866, a Novel Fibrinolytic Agent (II). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.11 ◽

1996 ◽

Vol 11 (1) ◽

pp. 11-29

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Saburo HIGUCHI ◽

Satoshi KUROSAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent

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Metabolic Fate of Roxatidine Acetate Hydrochloride. (9). Blood and Plasma Concentration, Tissue Distribution and Excretion in Male Rat after a Single Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.743 ◽

1995 ◽

Vol 10 (6) ◽

pp. 743-765

Author(s):

Kaoru UEDA ◽

Hiroyuki OCHIAI ◽

Yoshihiro KAWABE ◽

Seijiro HONMA ◽

Kunio TSUKAMOTO

Keyword(s):

Plasma Concentration ◽

Tissue Distribution ◽

Intravenous Administration ◽

Male Rat ◽

Metabolic Fate ◽

Roxatidine Acetate ◽

Single Intravenous Administration ◽

Acetate Hydrochloride

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Studies on the Metabolic Fate of M17055, a Novel Diuretic. (1): Plasma Concentration and Excretion of Radioactivity in Rat and Dog after a Single Intravenous Administration of [14C]M17055.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.16.304 ◽

2001 ◽

Vol 16 (4) ◽

pp. 304-313

Author(s):

Hiroyuki NAKAJIMA ◽

Takeshi NAKANISHI ◽

Hiroyasu NABA ◽

Hiroyuki TANAKA ◽

Keiichi IDA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Metabolic Fate ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (I): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.61 ◽

1998 ◽

Vol 13 (2) ◽

pp. 61-77 ◽

Cited By ~ 1

Author(s):

Shunji NAKAI ◽

Kyoko AKAO ◽

Masaki ITO ◽

Yoshiko MIZUNO ◽

Setsuko KOMURO ◽

...

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Antitumor Agent ◽

Metabolic Fate ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Ultra Short Acting .BETA.1 Blocker ONO-1101. (1). Plasma Concentration-time Profile, Distribution and Excretion after Single Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.5 ◽

1997 ◽

Vol 12 (1) ◽

pp. 5-21 ◽

Cited By ~ 1

Author(s):

Ken TSUNEKAWA ◽

Haruo IMAWAKA ◽

Hiroaki FUJIMOTO ◽

Masatsune ISHIDO ◽

Kimio SHIBAKAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Time Profile ◽

Metabolic Fate ◽

Short Acting ◽

Concentration Time ◽

Profile Distribution ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (2): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration of 125I-E6010.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.585 ◽

1996 ◽

Vol 11 (6) ◽

pp. 585-598

Author(s):

Hitoshi Mizuo ◽

Kiyomi KIKUCHI ◽

Mannen MISHIMA ◽

Masataka UEDA ◽

Teruaki YUZURIHA

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Type Plasminogen Activator

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Studies on the Metabolic Fate of M17055, a Novel Diuretic. (3): Plasma Concentration, Distribution and Excretion of Radioactivity in Male Rats after Repeated Daily Intravenous Administration of [14C]M17055.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.16.325 ◽

2001 ◽

Vol 16 (4) ◽

pp. 325-332

Author(s):

Hiroyuki NAKAJIMA ◽

Takeshi NAKANISHI ◽

Hiroyasu NABA ◽

Keiichi IDA ◽

Nobuo OHZAWA

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Male Rats ◽

Metabolic Fate

Download Full-text