Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (2): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration of 125I-E6010.

Hitoshi Mizuo; Kiyomi KIKUCHI; Mannen MISHIMA; Masataka UEDA; Teruaki YUZURIHA

doi:10.2133/dmpk.11.585

Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (2): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration of 125I-E6010.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.585 ◽

1996 ◽

Vol 11 (6) ◽

pp. 585-598

Author(s):

Hitoshi Mizuo ◽

Kiyomi KIKUCHI ◽

Mannen MISHIMA ◽

Masataka UEDA ◽

Teruaki YUZURIHA

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Type Plasminogen Activator

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Studies on the Metabolic Fate of Modified Recombinant Tissue-Type Plasminogen Activator (E6010) (1): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after a Single Intravenous Administration of l25I-E6010 in Comparison with l25I-Recombinant Tissue-Type Plasminogen Activator (rt-PA).

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.556 ◽

1996 ◽

Vol 11 (6) ◽

pp. 556-584

Author(s):

Hitoshi Mizuo ◽

Takayuki SEKO ◽

Koichi NOSE ◽

Tomomi ANDO ◽

Yoshiko KAGEI ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Tissue Type ◽

Metabolic Fate ◽

Tissue Type Plasminogen Activator ◽

Type Plasminogen Activator ◽

Single Intravenous Administration

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Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (1): Blood or plasma concentration, distribution, metabolism and excretion in rats after single intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.309 ◽

1988 ◽

Vol 3 (3) ◽

pp. 309-329 ◽

Cited By ~ 1

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Naoki TSUJII ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen ◽

Single Intravenous Administration

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Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (2): Blood or plasma concentration, distribution, metabolism, excretion and accumulation in rats after repeated intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.331 ◽

1988 ◽

Vol 3 (3) ◽

pp. 331-347

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Teiko KOMATSU

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen

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Metabolic Fate of YM866, a Novel Fibrinolytic Agent (II). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.11 ◽

1996 ◽

Vol 11 (1) ◽

pp. 11-29

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Saburo HIGUCHI ◽

Satoshi KUROSAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent

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Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (3): Feto-Placental Transfer and Excretion into Milk in Rats after a Single Intravenous Administration of l25I-E6010.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.599 ◽

1996 ◽

Vol 11 (6) ◽

pp. 599-606

Author(s):

Hitoshi MIZUO ◽

Tomomi ANDO ◽

Yoshiko KAGEI ◽

Mannen MISHIMA ◽

Teruaki YUZURIHA

Keyword(s):

Plasminogen Activator ◽

Intravenous Administration ◽

Placental Transfer ◽

Metabolic Fate ◽

Type Plasminogen Activator ◽

Single Intravenous Administration

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Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (II). Plasma Concentration, Distribution and Excretion after Repeated Intravenous Administration to 7-week Old Rats and after Single Intravenous Administration to 30-week Old Rats, and Transfer into the Fetus and Milk in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.174 ◽

1995 ◽

Vol 10 (2) ◽

pp. 174-189 ◽

Cited By ~ 3

Author(s):

Tsutomu MOCHIZUKI ◽

Shin-ichi NISHIMURA ◽

Koichiro OKABE ◽

Yoshiaki AZUMA ◽

Shin UMEDA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Old Rats ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of M17055, a Novel Diuretic. (3): Plasma Concentration, Distribution and Excretion of Radioactivity in Male Rats after Repeated Daily Intravenous Administration of [14C]M17055.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.16.325 ◽

2001 ◽

Vol 16 (4) ◽

pp. 325-332

Author(s):

Hiroyuki NAKAJIMA ◽

Takeshi NAKANISHI ◽

Hiroyasu NABA ◽

Keiichi IDA ◽

Nobuo OHZAWA

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Male Rats ◽

Metabolic Fate

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Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (III). Plasma Concentration, Distribution in Bone and Excretion after Intravenous Administration to Beagle Dogs.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.190 ◽

1995 ◽

Vol 10 (2) ◽

pp. 190-196

Author(s):

Tsutomu MOCHIZUKI ◽

Koichiro OKABE ◽

Shin UMEDA ◽

Satoshi KUDOH ◽

Noriko HARAKAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Beagle Dogs ◽

Metabolic Fate

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Metabolic Fate of YM866, a Novel Fibrinolytic Agent (I). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Single Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.1 ◽

1996 ◽

Vol 11 (1) ◽

pp. 1-10

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Ikuo MIYAMOTO ◽

Saburo HIGUCHI

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent ◽

Single Intravenous Administration

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Metabolic Fate of YM060. (1): Plasma Concentration, Distribution and Excretion after Intravenous Administration of 14C-YM060 to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.9.224 ◽

1994 ◽

Vol 9 (2) ◽

pp. 224-234

Author(s):

Eiji NAKAMURA ◽

Hajime IMASAKI ◽

Tetsuo TAKESHIGE ◽

Hiroya MIURA ◽

Shin-ichiro KOBAYASHI ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate

Download Full-text