Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (I): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Rats.

Shunji NAKAI; Kyoko AKAO; Masaki ITO; Yoshiko MIZUNO; Setsuko KOMURO; Hiroshi KANAMARU; Iwao NAKATSUKA; Yoshio ESUMI; Masao ISHIZAKI; Shinobu GUNJI; Atsushi TAKAO; Kazue KIMURA; Tomoko NAKAYAMA; Shinichi NINOMIYA

doi:10.2133/dmpk.13.61

Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (I): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.61 ◽

1998 ◽

Vol 13 (2) ◽

pp. 61-77 ◽

Cited By ~ 1

Author(s):

Shunji NAKAI ◽

Kyoko AKAO ◽

Masaki ITO ◽

Yoshiko MIZUNO ◽

Setsuko KOMURO ◽

...

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Antitumor Agent ◽

Metabolic Fate ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (III): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Dogs.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.91 ◽

1998 ◽

Vol 13 (2) ◽

pp. 91-99

Author(s):

Shunji NAKAI ◽

Kyoko AKAO ◽

Masaki ITO ◽

Setsuko KOMURO ◽

Hiroshi KANAMARU ◽

...

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Antitumor Agent ◽

Metabolic Fate ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (II): Blood Concentration, Distribution, Metabolism and Excretion after Repeated Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.78 ◽

1998 ◽

Vol 13 (2) ◽

pp. 78-90

Author(s):

Shunji NAKAI ◽

Kyoko AKAO ◽

Masaki ITO ◽

Hiroshi KANAMARU ◽

Iwao NAKATSUKA

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Antitumor Agent ◽

Metabolic Fate

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Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (1): Blood or plasma concentration, distribution, metabolism and excretion in rats after single intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.309 ◽

1988 ◽

Vol 3 (3) ◽

pp. 309-329 ◽

Cited By ~ 1

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Naoki TSUJII ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen ◽

Single Intravenous Administration

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Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (II). Plasma Concentration, Distribution and Excretion after Repeated Intravenous Administration to 7-week Old Rats and after Single Intravenous Administration to 30-week Old Rats, and Transfer into the Fetus and Milk in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.174 ◽

1995 ◽

Vol 10 (2) ◽

pp. 174-189 ◽

Cited By ~ 3

Author(s):

Tsutomu MOCHIZUKI ◽

Shin-ichi NISHIMURA ◽

Koichiro OKABE ◽

Yoshiaki AZUMA ◽

Shin UMEDA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Old Rats ◽

Single Intravenous Administration

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Metabolic Fate of NKH477. (2). Blood Concentration, Distribution, Excretion and Effects on Drug-Metabolizing Enzyme System in Rats after Repeated Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.221 ◽

1998 ◽

Vol 13 (3) ◽

pp. 221-228

Author(s):

Shin-ichi MATSUMOTO ◽

Tsuyoshi IRIE ◽

Toshiko EKI ◽

Kouwa YAMASHITA ◽

Hideaki SEKI ◽

...

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Enzyme System ◽

Metabolic Fate ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Metabolic Fate of YM866, a Novel Fibrinolytic Agent (I). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Single Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.1 ◽

1996 ◽

Vol 11 (1) ◽

pp. 1-10

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Ikuo MIYAMOTO ◽

Saburo HIGUCHI

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Modified Recombinant Tissue-Type Plasminogen Activator (E6010) (1): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after a Single Intravenous Administration of l25I-E6010 in Comparison with l25I-Recombinant Tissue-Type Plasminogen Activator (rt-PA).

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.556 ◽

1996 ◽

Vol 11 (6) ◽

pp. 556-584

Author(s):

Hitoshi Mizuo ◽

Takayuki SEKO ◽

Koichi NOSE ◽

Tomomi ANDO ◽

Yoshiko KAGEI ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Tissue Type ◽

Metabolic Fate ◽

Tissue Type Plasminogen Activator ◽

Type Plasminogen Activator ◽

Single Intravenous Administration

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Metabolic Fate of NKH477. (3). Feto-Placental Transfer and Excretion into Milk in Rats after a Single Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.229 ◽

1998 ◽

Vol 13 (3) ◽

pp. 229-236

Author(s):

Tsuyoshi IRIE ◽

Shin-ichi MATSUMOTO ◽

Rika GODA ◽

Toshiko EKI ◽

Kouwa YAMASHITA

Keyword(s):

Intravenous Administration ◽

Placental Transfer ◽

Metabolic Fate ◽

Single Intravenous Administration

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Disposition and Metabolism of ST-630. (3). Dose-response, Effect of Food Intake, Bioavailability after Single Oral Administration, and Serum Concentration, Distribution, Metabolism, Excretion after Single Intravenous Administration of 3H-ST-630 in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.530 ◽

1996 ◽

Vol 11 (5) ◽

pp. 530-540

Author(s):

Setsuko KOMURO ◽

Hiroshi KANAMARU ◽

Iwao NAKATSUKA ◽

Akira YOSHITAKE ◽

Masao ISHIZAKI ◽

...

Keyword(s):

Food Intake ◽

Serum Concentration ◽

Oral Administration ◽

Intravenous Administration ◽

Dose Response ◽

Concentration Distribution ◽

Single Oral Administration ◽

Effect Of Food ◽

Dose Response Effect ◽

Single Intravenous Administration

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Metabolic Fate of YM866, a Novel Fibrinolytic Agent (II). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.11 ◽

1996 ◽

Vol 11 (1) ◽

pp. 11-29

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Saburo HIGUCHI ◽

Satoshi KUROSAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent

Download Full-text