scholarly journals Antidiabetic agent did not impair spermatogenesis in spontaneously hyperglycemic and diabetic rats

2021 ◽  
Vol 8 (4) ◽  
pp. 97-101
Author(s):  
Taiki Kobayashi ◽  
Takasumi Shimomoto ◽  
Junichi Namekawa ◽  
Masanobu Kanou ◽  
Hirotsugu Kato ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Agent

scholarly journals Effects of Combination of Antidiabetic Agent and Statin on Alloxan-induced Diabetes with Cardiovascular Diseases in Rats

2012 ◽  
Vol 4 (3) ◽  
pp. 709-720 ◽  
Author(s):  
M. S. Islam ◽  
A. H. M. K. Alam ◽  
M. A. A. Rahman ◽  
Y. Ali ◽  
Al Mamun ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Diabetic Rats ◽  
Free Radical Scavenging ◽  
Scavenging Activity ◽  
Antidiabetic Agent ◽  
Pathological Changes ◽  
Short Term ◽  
Combination Drugs

The present study was designed to investigate the effects of combination drugs (metformin and atorvastatin) on long-term alloxan-induced diabetes with CVD in rats. In short-term alloxan-induced diabetic rats, metformin reduced significant amount of glucose in blood, but it had no significant effect on lipid profile. Atorvastatin significantly reduced TC, TG and LDL-C, whereas it increased significant amount of HDL-C. However, pathological changes of heart were not observed after short-term induction of alloxan in rats. In long-term induction of diabetes by alloxan, LV hypertrophy was observed and cardimyocyte size in rats was increased. Atorvastatin alone and in combination with metformin significantly reduced the LV hypertrophy, cardiomyocyte size, TC, TG and LDL-C level. They increased significant amount of HDL-C level and showed significant DPPH free radical scavenging activity. Present findings may suggest that treatment with combination therapy is more effective than mono-therapy for preventing diabetes with CVD in rats.© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v4i3.9974 J. Sci. Res. 4 (3), 709-720 (2012)

Assessment of the antidiabetic activity of epicatechin in streptozotocin-diabetic and spontaneously diabetic BB/E rats

1985 ◽  
Vol 5 (3) ◽  
pp. 215-221 ◽  
Author(s):  
A. J. bone ◽  
C. S. T. Hii ◽  
D. Brown ◽  
W. Smith ◽  
S. L. Howell
Keyword(s):  
Alloxan Diabetes ◽  
Insulin Dependent Diabetes Mellitus ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Dependent Diabetes Mellitus ◽  
Antidiabetic Agent ◽  
Therapeutic Value ◽  
Insulin Dependent ◽  
Streptozotocin Diabetic Rats ◽  
Potential Use

(−)-Epicatechin has previously been suggested to rapidly reverse alloxan diabetes in rats. We have assessed the therapeutic value of the compound in two further animal models of insulin-dependent diabetes mellitus, namely streptozotocin – diabetic rats and the spontaneously diabetic BB/E rat. There was no indication of a reversal of established diabetes in either the streptozotocin-diabetic or the spontaneously diabetic BB/E rats. Moreover, epicatechin also failed to halt the progression of the disease in prediabetic BB/E rats. Earlier claims of the potential use of epicatechin as an antidiabetic agent must therefore be treated with some caution.

scholarly journals Tungstate is an effective antidiabetic agent in streptozotocin-induced diabetic rats: a long-term study

Diabetologia ◽  
2001 ◽  
Vol 44 (4) ◽  
pp. 507-513 ◽  
Author(s):  
A. Barberà ◽  
R. R. Gomis ◽  
N. Prats ◽  
J. E. Rodríguez-Gil ◽  
M. Domingo ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Agent ◽  
Term Study ◽  
Long Term Study

Amelioration of Hyperglycemia in Streptozotocin-Induced Diabetic Rats Receiving a Marginal Mass of Islet Grafts by Troglitazone, an Oral Antidiabetic Agent

Pancreas ◽  
1996 ◽  
Vol 13 (4) ◽  
pp. 381-387 ◽  
Author(s):  
Tetsu Nagai ◽  
Yohichi Yasunami ◽  
Naoki Nagata ◽  
Shinichiroh Ryu ◽  
Junko Ono ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Agent ◽  
Oral Antidiabetic Agent ◽  
Oral Antidiabetic

scholarly journals Apigenin: A methanol fraction component of Newbouldia laevis leaf, as a potential antidiabetic agent

2017 ◽  
Vol 6 (1) ◽  
pp. 38-44
Author(s):  
Chinyelu C. Osigwe ◽  
◽  
Peter A. Akah ◽  
Chukwuemeka S. Nworu ◽  
Festus B. C. Okoye ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Muscle Glycogen ◽  
Glycogen Content ◽  
Diabetic Rats ◽  
Antidiabetic Agent ◽  
Methanol Fraction ◽  
Antihyperglycemic Activity ◽  
Muscle Glycogen Content ◽  
Isolated Compound

The leaves of Newbouldia laevis is traditionally used to treat diabetes mellitus in southeast Nigeria. The apigenin isolated from the methanol fraction of dichloromethane/methanol (1:1) extract of the leaves was evaluated for antidiabetic and antihyperglycemic activity in alloxan-induced diabetic rats and on normal rats. Treatment of alloxan-diabetic rats with the compound (apigenin) significantly (p < 0.05) reduced blood glucose, and increased the liver and muscle glycogen content. The adrenaline-induced elevation of blood glucose of normal rats was significantly (p < 0.05) reduced by the isolated compound. These results suggest that apigenin may be the anti-diabetic principle in the leaves of Newbouldia laevis..

scholarly journals Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats

1997 ◽  
Vol 120 (6) ◽  
pp. 1135-1143 ◽  
Author(s):  
R B Jones ◽  
K Dickinson ◽  
D M Anthony ◽  
A R Marita ◽  
C L Kaul ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Agent
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