scholarly journals Tungstate is an effective antidiabetic agent in streptozotocin-induced diabetic rats: a long-term study

Diabetologia ◽  
2001 ◽  
Vol 44 (4) ◽  
pp. 507-513 ◽  
Author(s):  
A. Barberà ◽  
R. R. Gomis ◽  
N. Prats ◽  
J. E. Rodríguez-Gil ◽  
M. Domingo ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Agent ◽  
Term Study ◽  
Long Term Study

scholarly journals LONG-TERM STUDY OF ERYTHROPOIETIN, LOSARTAN, AND COMBINATION IN STREPT- OZOTOCIN-INDUCED DIABETIC RATS

2020 ◽  
Vol 42 (1) ◽  
pp. 45-85
Author(s):  
Rehab Ashour ◽  
Abd El-Motaal Fouda ◽  
Mohamed Saad ◽  
Farida El-Banna ◽  
Fatma Moustafa
Keyword(s):  
Diabetic Rats ◽  
Term Study ◽  
Long Term Study

Influence of Helicteres isora L. Bark Extracts on Glycaemic Control and Renoprotective Activity in Streptozotocin-induced Diabetic Rats

1970 ◽  
Vol 1 (3) ◽  
pp. 275-280
Author(s):  
Ganesan Kumar ◽  
Gani Sharmila banu ◽  
Arunachalam Ganesan Murugesan
Keyword(s):  
Blood Glucose ◽  
Glycaemic Control ◽  
Diabetic Rats ◽  
Short Term ◽  
Term Study ◽  
Standard Drug ◽  
Long Term Study ◽  
Helicteres Isora ◽  
Enhanced Secretion

The present investigation, the aqueous bark extracts of Helicteres isora was investigated on glycaemic control and renoprotective activity in streptozotocin-induced diabetic rats using short term and long term study. The blood glucose lowering activity of the bark extracts (100, 200mg/kg) was determined in streptozotocin-induced (60 mg/kg) diabetic rats in short term study. Blood samples were collected at 0.5, 1, 2, 4, 6, 8 and 12 h after bark extracts administration and the samples were analyzed for blood glucose.  In long term study, the bark extracts (100, 200 mg/kg) were administered to streptozotocin-induced diabetic rats, daily for 8 weeks. Blood glucose was measured at weekly intervals for 4 weeks. Urine samples were collected before the induction of diabetes and at the end of 8 weeks of treatments and analyzed for urinary protein, albumin and creatinine levels. The results shows that the aqueous bark extracts of Helicteres isora produced dose-dependent reduction in blood glucose of diabetic rats and comparable with that of standard drug, tolbutamide. The renoprotective activity is also observed in bark extracts treated rats. The results indicate a prolonged action in reduction of blood glucose by Helicteres isora and are probably mediated through enhanced secretion of insulin from the β-cells of Langerhans or through extra pancreatic mechanism. The probable mechanism of potent renoprotective actions of Helicteres isora has to be evaluated.

Quinapril for Sclerosis Failed in Long-Term Study

2007 ◽  
Vol 38 (6) ◽  
pp. 14
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Term Study ◽  
Long Term Study
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