scholarly journals Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 39118-39135 ◽  
Author(s):  
Sylvie L. Lesuis ◽  
Herve Maurin ◽  
Peter Borghgraef ◽  
Paul J. Lucassen ◽  
Fred Van Leuven ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Mouse Model ◽  
Early Life ◽  
Life Experiences ◽  
Amyloid Protein ◽  
Term Survival ◽  
Long Term Survival ◽  
Protein Levels ◽  
Model Of Alzheimer’S Disease

Prolonged Volatile Anesthetic Exposure Exacerbates Cognitive Impairment and Neuropathology in the 5xFAD Mouse Model of Alzheimer’s Disease

2021 ◽  
pp. 1-12
Author(s):  
Fanglei Han ◽  
Jia Zhao ◽  
Guoqing Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Volatile Anesthetics ◽  
Model Of Alzheimer’S Disease ◽  
Short Term Exposure ◽  
5Xfad Mouse ◽  
Anesthetic Exposure ◽  
5Xfad Mice

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease which shows a set of symptoms involving cognitive changes and psychological changes. Given that AD is the most common form of dementia in aging population and the increasing demand for anesthesia/surgery with aging, there has been significant interest in the exact impact of volatile anesthetics on cognitive function and pathological alterations in AD population. Objective: This study aimed to investigate behavioral changes and neuropathology in the 5xFAD mouse model of Alzheimer’s disease with short-term exposure or long-term exposure to desflurane, sevoflurane, or isoflurane. Methods: In this study, we exposed 5xFAD mouse model of AD to isoflurane, sevoflurane, or desflurane in two different time periods (30 min and 6 h), and the memory related behaviors as well as the pathological changes in 5xFAD mice were evaluated 7 days after the anesthetic exposure. Results: We found that short-term exposure to volatile anesthetics did not affect hippocampus dependent memory and the amyloid-β (Aβ) deposition in the brain. However, long-term exposure to sevoflurane or isoflurane significantly increased the Aβ deposition in CA1 and CA3 regions of hippocampus, as well as the glial cell activation in amygdala. Besides, the PSD-95 expression was decreased in 5xFAD mice with exposure to sevoflurane or isoflurane and the caspase-3 activation was enhanced in isoflurane, sevoflurane, and desflurane groups. Conclusion: Our results demonstrate the time-dependent effects of common volatile anesthetics and implicate that desflurane has the potential benefits to prolonged anesthetic exposure in AD patients.

FTY720 Application Following Isolated Warm Liver Ischemia Improves Long-Term Survival and Organ Protection in a Mouse Model

2007 ◽  
Vol 39 (2) ◽  
pp. 493-498 ◽  
Author(s):  
C.P. Kaudel ◽  
M. Frink ◽  
M. van Griensven ◽  
U. Schmiddem ◽  
C. Probst ◽  
...  
Keyword(s):  
Mouse Model ◽  
Liver Ischemia ◽  
Organ Protection ◽  
Term Survival ◽  
Long Term Survival ◽  
Warm Liver Ischemia

Human neurons that constitutively secrete Aβ do not induce Alzheimer's disease pathology following transplantation and long-term survival in the rodent brain

1995 ◽  
Vol 671 (2) ◽  
pp. 333-337 ◽  
Author(s):  
John R. Mantione ◽  
Sofie R. Kleppner ◽  
Masayuki Miyazono ◽  
Andrew M. Wertkin ◽  
Virginia M.-Y. Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Term Survival ◽  
Long Term Survival ◽  
Rodent Brain ◽  
Human Neurons

scholarly journals Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model

2016 ◽  
Vol 139 (1) ◽  
pp. 194-204 ◽  
Author(s):  
Kelly Waldeck ◽  
Carleen Cullinane ◽  
Kerry Ardley ◽  
Jake Shortt ◽  
Ben Martin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Terminal Differentiation ◽  
Continuous Exposure ◽  
Term Survival ◽  
Long Term Survival
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