scholarly journals Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model

2016 ◽  
Vol 139 (1) ◽  
pp. 194-204 ◽  
Author(s):  
Kelly Waldeck ◽  
Carleen Cullinane ◽  
Kerry Ardley ◽  
Jake Shortt ◽  
Ben Martin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Terminal Differentiation ◽  
Continuous Exposure ◽  
Term Survival ◽  
Long Term Survival

FTY720 Application Following Isolated Warm Liver Ischemia Improves Long-Term Survival and Organ Protection in a Mouse Model

2007 ◽  
Vol 39 (2) ◽  
pp. 493-498 ◽  
Author(s):  
C.P. Kaudel ◽  
M. Frink ◽  
M. van Griensven ◽  
U. Schmiddem ◽  
C. Probst ◽  
...  
Keyword(s):  
Mouse Model ◽  
Liver Ischemia ◽  
Organ Protection ◽  
Term Survival ◽  
Long Term Survival ◽  
Warm Liver Ischemia

scholarly journals Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD

2019 ◽  
Vol 27 (8) ◽  
pp. 1436-1451
Author(s):  
Sabine Geiger ◽  
Emrah I. Ozay ◽  
Ulf Geumann ◽  
Marina K. Hereth ◽  
Terese Magnusson ◽  
...  
Keyword(s):  
Mouse Model ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Survival Benefit ◽  
Term Survival ◽  
Long Term Survival ◽  
Alpha 1 Antitrypsin

scholarly journals Osimertinib regressed an EGFR-mutant lung-adenocarcinoma bone-metastasis mouse model and increased long-term survival

2020 ◽  
Vol 13 (10) ◽  
pp. 100826
Author(s):  
Takashi Higuchi ◽  
Norihiko Sugisawa ◽  
Jun Ho Park ◽  
Yu Sun ◽  
Guangwei Zhu ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Mouse Model ◽  
Lung Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Egfr Mutant

scholarly journals Mitomycin-C Treatment Followed by Culture Produces Long-Term Survival of Islet Xenografts in a Rat-to Mouse Model

2008 ◽  
Vol 17 (6) ◽  
pp. 619-629 ◽  
Author(s):  
Takashi Gunji ◽  
Takuro Saito ◽  
Yoshihiro Sato ◽  
Shinichi Matsuyama ◽  
Kazuya Ise ◽  
...  
Keyword(s):  
Mouse Model ◽  
Mitomycin C ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL

Blood ◽  
2015 ◽  
Vol 125 (9) ◽  
pp. 1444-1451 ◽  
Author(s):  
Iris Appelmann ◽  
Cory D. Rillahan ◽  
Elisa de Stanchina ◽  
Gregory Carbonetti ◽  
Chong Chen ◽  
...  
Keyword(s):  
B Cells ◽  
Mouse Model ◽  
Janus Kinase ◽  
Term Survival ◽  
Kinase Inhibition ◽  
Long Term Survival ◽  
Abl Kinase ◽  
Key Points ◽  
Janus Kinase Inhibition

Key Points In a Ph+ ALL mouse model, dasatinib inhibition of the BCR-ABL kinase resensitizes residual leukemic B cells to Janus kinase inhibition. Dasatinib, ruxolitinib, and dexamethasone together limit emergence of dasatinib-resistant BCR-ABL mutants and extend long-term survival.

scholarly journals Deletion of Two Genes in Burkholderia pseudomallei MSHR668 That Target Essential Amino Acids Protect Acutely Infected BALB/c Mice and Promote Long Term Survival

Vaccines ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 196 ◽  
Author(s):  
Kei Amemiya ◽  
Jennifer L. Dankmeyer ◽  
Sergei S. Biryukov ◽  
Sylvia R. Treviño ◽  
Christopher P. Klimko ◽  
...  
Keyword(s):  
Mouse Model ◽  
Acute Phase ◽  
Burkholderia Pseudomallei ◽  
Lethal Dose ◽  
Chronic Phase ◽  
Essential Amino Acids ◽  
Term Survival ◽  
Long Term Survival ◽  
Susceptibility To Infection

Melioidosis is an emerging disease that is caused by the facultative intracellular pathogen Burkholderia pseudomallei. It is intrinsically resistant to many antibiotics and host risk factors play a major role in susceptibility to infection. Currently, there is no human or animal vaccine against melioidosis. In this study, multiple B. pseudomallei MSHR668 deletion mutants were evaluated as live attenuated vaccines in the sensitive BALB/c mouse model of melioidosis. The most efficacious vaccines after an intraperitoneal challenge with 50-fold over the 50% median lethal dose (MLD50) with B. pseudomallei K96243 were 668 ΔhisF and 668 ΔilvI. Both vaccines completely protected mice in the acute phase of infection and showed significant protection (50% survivors) during the chronic phase of infection. The spleens of the survivors that were examined were sterile. Splenocytes from mice vaccinated with 668 ΔhisF and 668 ΔilvI expressed higher amounts of IFN-γ after stimulation with B. pseudomallei antigens than splenocytes from mice vaccinated with less protective candidates. Finally, we demonstrate that 668 ΔhisF is nonlethal in immunocompromised NOD/SCID mice. Our results show that 668 ΔhisF and 668 ΔilvI provide protective cell-mediated immune responses in the acute phase of infection and promote long term survival in the sensitive BALB/c mouse model of melioidosis.

scholarly journals Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 39118-39135 ◽  
Author(s):  
Sylvie L. Lesuis ◽  
Herve Maurin ◽  
Peter Borghgraef ◽  
Paul J. Lucassen ◽  
Fred Van Leuven ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Mouse Model ◽  
Early Life ◽  
Life Experiences ◽  
Amyloid Protein ◽  
Term Survival ◽  
Long Term Survival ◽  
Protein Levels ◽  
Model Of Alzheimer’S Disease

Human thymic epithelial cells maintain long-term survival of clonogenic myeloid and erythroid progenitor cells in vitro

2000 ◽  
Vol 111 (1) ◽  
pp. 363-370 ◽  
Author(s):  
Katsuto Takenaka ◽  
Mine Harada ◽  
Tomoaki Fujisaki ◽  
Koji Nagafuji ◽  
Shinichi Mizuno ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Progenitor Cells ◽  
Thymic Epithelial Cells ◽  
Erythroid Progenitor ◽  
Term Survival ◽  
Long Term Survival ◽  
Erythroid Progenitor Cells

Clinical outcome and long-term survival following radical esophagectomy in the elderly

2001 ◽  
Vol 120 (5) ◽  
pp. A747-A748
Author(s):  
S DRESNER ◽  
A IMMMANUEL ◽  
P LAMB ◽  
S GRIFFIN
Keyword(s):  
Clinical Outcome ◽  
The Elderly ◽  
Radical Esophagectomy ◽  
Term Survival ◽  
Long Term Survival
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