Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease

2012 ◽  
Vol 102 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Dongmei Wang ◽  
Kai Gao ◽  
Xiaoying Li ◽  
Xinhua Shen ◽  
Xu Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Glucose Uptake ◽  
Cognitive Deficits ◽  
Model Of Alzheimer’S Disease

P1-033: Cognitive deficits and plaque deposition in a gene-targeted mouse model of Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_6) ◽  
pp. P181-P181
Author(s):  
John Ciallella ◽  
Heather Hain ◽  
Bryan Strenkowski ◽  
Michelle Hogga ◽  
Stacey Galvin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cognitive Deficits ◽  
Plaque Deposition ◽  
Model Of Alzheimer’S Disease

Prolonged Volatile Anesthetic Exposure Exacerbates Cognitive Impairment and Neuropathology in the 5xFAD Mouse Model of Alzheimer’s Disease

2021 ◽  
pp. 1-12
Author(s):  
Fanglei Han ◽  
Jia Zhao ◽  
Guoqing Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Volatile Anesthetics ◽  
Model Of Alzheimer’S Disease ◽  
Short Term Exposure ◽  
5Xfad Mouse ◽  
Anesthetic Exposure ◽  
5Xfad Mice

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disease which shows a set of symptoms involving cognitive changes and psychological changes. Given that AD is the most common form of dementia in aging population and the increasing demand for anesthesia/surgery with aging, there has been significant interest in the exact impact of volatile anesthetics on cognitive function and pathological alterations in AD population. Objective: This study aimed to investigate behavioral changes and neuropathology in the 5xFAD mouse model of Alzheimer’s disease with short-term exposure or long-term exposure to desflurane, sevoflurane, or isoflurane. Methods: In this study, we exposed 5xFAD mouse model of AD to isoflurane, sevoflurane, or desflurane in two different time periods (30 min and 6 h), and the memory related behaviors as well as the pathological changes in 5xFAD mice were evaluated 7 days after the anesthetic exposure. Results: We found that short-term exposure to volatile anesthetics did not affect hippocampus dependent memory and the amyloid-β (Aβ) deposition in the brain. However, long-term exposure to sevoflurane or isoflurane significantly increased the Aβ deposition in CA1 and CA3 regions of hippocampus, as well as the glial cell activation in amygdala. Besides, the PSD-95 expression was decreased in 5xFAD mice with exposure to sevoflurane or isoflurane and the caspase-3 activation was enhanced in isoflurane, sevoflurane, and desflurane groups. Conclusion: Our results demonstrate the time-dependent effects of common volatile anesthetics and implicate that desflurane has the potential benefits to prolonged anesthetic exposure in AD patients.

scholarly journals Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

Redox Biology ◽  
2017 ◽  
Vol 12 ◽  
pp. 843-853 ◽  
Author(s):  
Athanassios Fragoulis ◽  
Stephanie Siegl ◽  
Markus Fendt ◽  
Sandra Jansen ◽  
Ulf Soppa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Oral Administration ◽  
Cognitive Deficits ◽  
Model Of Alzheimer’S Disease
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