Niemann-Pick C1 Mice, a Model of “Juvenile Alzheimer's Disease”, with Normal Gene Expression in Neurons and Fibrillary Astrocytes Show Long Term Survival and Delayed Neurodegeneration

2012 ◽  
Vol 30 (4) ◽  
pp. 875-887 ◽  
Author(s):  
Ivan Borbon ◽  
John Totenhagen ◽  
Maria Teresa Fiorenza ◽  
Sonia Canterini ◽  
Wangjing Ke ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Term Survival ◽  
Long Term Survival ◽  
Normal Gene ◽  
Niemann Pick

Human neurons that constitutively secrete Aβ do not induce Alzheimer's disease pathology following transplantation and long-term survival in the rodent brain

1995 ◽  
Vol 671 (2) ◽  
pp. 333-337 ◽  
Author(s):  
John R. Mantione ◽  
Sofie R. Kleppner ◽  
Masayuki Miyazono ◽  
Andrew M. Wertkin ◽  
Virginia M.-Y. Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Term Survival ◽  
Long Term Survival ◽  
Rodent Brain ◽  
Human Neurons

scholarly journals P1-104: Long-term survival of dystrophic axons and their cell bodies in Alzheimer's disease pathology

2008 ◽  
Vol 4 ◽  
pp. T237-T237
Author(s):  
Robert Adalbert ◽  
Antal Nogradi ◽  
Elisabetta Babetto ◽  
Lucie Janeckova ◽  
Simon A. Walker ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Term Survival ◽  
Long Term Survival ◽  
Dystrophic Axons

Lentivirus-Mediated Expression of Human Secreted Amyloid Precursor Protein-Alpha Promotes Long-Term Induction of Neuroprotective Genes and Pathways in a Mouse Model of Alzheimer’s Disease

2020 ◽  
pp. 1-16
Author(s):  
Margaret Ryan ◽  
Valerie T.Y. Tan ◽  
Nasya Thompson ◽  
Diane Guévremont ◽  
Bruce G. Mockett ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Integrated Analysis ◽  
Empty Vector ◽  
Mouse Transcriptome

Background: Secreted amyloid precursor protein-alpha (sAPPα) can enhance memory and is neurotrophic and neuroprotective across a range of disease-associated insults, including amyloid-β toxicity. In a significant step toward validating sAPPα as a therapeutic for Alzheimer’s disease (AD), we demonstrated that long-term overexpression of human sAPPα (for 8 months) in a mouse model of amyloidosis (APP/PS1) could prevent the behavioral and electrophysiological deficits that develop in these mice. Objective: To explore the underlying molecular mechanisms responsible for the significant physiological and behavioral improvements observed in sAPPα-treated APP/PS1 mice. Methods: We assessed the long-term effects on the hippocampal transcriptome following continuous lentiviral delivery of sAPPα or empty-vector to male APP/PS1 mice and wild-type controls using Affymetrix Mouse Transcriptome Assays. Data analysis was carried out within the Affymetrix Transcriptome Analysis Console and an integrated analysis of the resulting transcriptomic data was performed with Ingenuity Pathway analysis (IPA). Results: Mouse transcriptome assays revealed expected AD-associated gene expression changes in empty-vector APP/PS1 mice, providing validation of the assays used for the analysis. By contrast, there were specific sAPPα-associated gene expression profiles which included increases in key neuroprotective genes such as Decorin, betaine-GABA transporter, and protocadherin beta-5, subsequently validated by qRT-PCR. An integrated biological pathways analysis highlighted regulation of GABA receptor signaling, cell survival, and inflammatory responses. Furthermore, upstream gene regulatory analysis implicated sAPPα activation of Interleukin-4, which can counteract inflammatory changes in AD. Conclusion: This study identified key molecular processes that likely underpin the long-term neuroprotective and therapeutic effects of increasing sAPPα levels in vivo

Predictive value of gene expression profiling for long-term survival after heart transplantation

2017 ◽  
Vol 41 ◽  
pp. 27-31 ◽  
Author(s):  
Buntaro Fujita ◽  
Emir Prashovikj ◽  
Uwe Schulz ◽  
Jochen Börgermann ◽  
Jakub Sunavsky ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Transplantation ◽  
Gene Expression Profiling ◽  
Predictive Value ◽  
Expression Profiling ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Survival of and In Situ Gene Expression by Vibrio vulnificus at Varying Salinities in Estuarine Environments

2007 ◽  
Vol 74 (1) ◽  
pp. 182-187 ◽  
Author(s):  
Melissa K. Jones ◽  
Elizabeth Warner ◽  
James D. Oliver
Keyword(s):  
Gene Expression ◽  
Vibrio Vulnificus ◽  
Natural Habitat ◽  
Term Survival ◽  
Long Term Survival ◽  
Wide Range ◽  
Opportunistic Human Pathogen

ABSTRACT The opportunistic human pathogen Vibrio vulnificus survives in a wide range of ecological environments, which demonstrates its ability to adapt to highly variable conditions. Survival and gene expression under various conditions have been extensively studied in vitro; however, little work has been done to evaluate this bacterium in its natural habitat. Therefore, this study monitored the long-term survival of V. vulnificus in situ and simultaneously evaluated the expression of stress (rpoS, relA, hfq, and groEL) and putative virulence (vvpE, smcR, viuB, and trkA) genes at estuarine sites of varying salinity. Additionally, the survival and gene expression of an rpoS and an oxyR mutant were examined under the same conditions. Differences between the sampling sites in the long-term survival of any strain were not seen. However, differences were seen in the expression of viuB, trkA, and relA but our findings differed from what has been previously shown in vitro. These results also routinely demonstrated that genes required for survival under in vitro stress or host conditions are not necessarily required for survival in the water column. Overall, this study highlights the need for further in situ evaluation of this bacterium in order to gain a true understanding of its ecology and how it relates to its natural habitat.

scholarly journals Patterns of Gene Expression That Characterize Long-term Survival in Advanced Stage Serous Ovarian Cancers

2005 ◽  
Vol 11 (10) ◽  
pp. 3686-3696 ◽  
Author(s):  
Andrew Berchuck ◽  
Edwin S. Iversen ◽  
Johnathan M. Lancaster ◽  
Jennifer Pittman ◽  
Jingqin Luo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Advanced Stage ◽  
Term Survival ◽  
Long Term Survival ◽  
Ovarian Cancers

Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression

1994 ◽  
Vol 5 (8) ◽  
pp. 465-472 ◽  
Author(s):  
J. R. Dorin ◽  
B. J. Stevenson ◽  
S. Fleming ◽  
E. W. F. W. Alton ◽  
P. Dickinson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cystic Fibrosis ◽  
Mutant Mouse ◽  
Cftr Gene ◽  
Wild Type ◽  
Term Survival ◽  
Long Term Survival ◽  
Low Level ◽  
Exon 10
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