scholarly journals The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

Oncotarget ◽  
2015 ◽  
Vol 6 (18) ◽  
pp. 15902-15930 ◽  
Author(s):  
Sharon E. Mitchell ◽  
Zhanhui Tang ◽  
Celine Kerbois ◽  
Camille Delville ◽  
Penelope Konstantopedos ◽  
...  
Oncotarget ◽  
2016 ◽  
Vol 7 (15) ◽  
pp. 19147-19170 ◽  
Author(s):  
Sharon E. Mitchell ◽  
Camille Delville ◽  
Penelope Konstantopedos ◽  
Davina Derous ◽  
Cara L. Green ◽  
...  

2012 ◽  
Vol 302 (4) ◽  
pp. E441-E448 ◽  
Author(s):  
Susan B. Racette ◽  
Sai Krupa Das ◽  
Manjushri Bhapkar ◽  
Evan C. Hadley ◽  
Susan B. Roberts ◽  
...  

Calorie restriction (CR) is a component of most weight loss interventions and a potential strategy to slow aging. Accurate determination of energy intake and %CR is critical when interpreting the results of CR interventions; this is most accurately achieved using the doubly labeled water method to quantify total energy expenditure (TEE). However, the costs and analytical requirements of this method preclude its repeated use in many clinical trials. Our aims were to determine 1) the optimal TEE assessment time points for quantifying average energy intake and %CR during long-term CR interventions and 2) the optimal approach for quantifying short-term changes in body energy stores to determine energy intake and %CR during 2-wk DLW periods. Adults randomized to a CR intervention in the multicenter CALERIE study underwent measurements of TEE by doubly labeled water and body composition at baseline and months 1, 3, and 6. Average %CR achieved during the intervention was 24.9 ± 8.7%, which was computed using an approach that included four TEE assessment time points (i.e., TEEbaseline, months 1, 3, and 6) plus the 6-mo change in body composition. Approaches that included fewer TEE assessments yielded %CR values of 23.4 ± 9.0 (TEEbaseline, months 3 and 6), 25.0 ± 8.7 (TEEbaseline, months 1 and 6), and 20.9 ± 7.1% (TEEbaseline, month 6); the latter approach differed significantly from approach 1 ( P < 0.001). TEE declined 9.6 ± 9.9% within 2–4 wk of CR beginning and then stabilized. Regression of daily home weights provided the most reliable estimate of short-term change in energy stores. In summary, optimal quantification of energy intake and %CR during weight loss necessitates a TEE measurement within the first month of CR to capture the rapid reduction in TEE.


Oncotarget ◽  
2015 ◽  
Vol 6 (21) ◽  
pp. 18314-18337 ◽  
Author(s):  
Sharon E. Mitchell ◽  
Camille Delville ◽  
Penelope Konstantopedos ◽  
Davina Derous ◽  
Cara L. Green ◽  
...  

Oncotarget ◽  
2017 ◽  
Vol 8 (11) ◽  
pp. 17453-17474 ◽  
Author(s):  
Sharon E. Mitchell ◽  
ZhanHui Tang ◽  
Celine Kerbois ◽  
Camille Delville ◽  
Davina Derous ◽  
...  

Hypertension ◽  
1996 ◽  
Vol 27 (3) ◽  
pp. 408-413 ◽  
Author(s):  
Minoru Kawamura ◽  
Toshiyuki Adachi ◽  
Jun Nakajima ◽  
Takuya Fujiwara ◽  
Katsuhiko Hiramori

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
D. M. Sontam ◽  
M. H. Vickers ◽  
J. M. O’Sullivan ◽  
M. Watson ◽  
E. C. Firth

Physical activity has a vital role in regulating and improving bone strength. Responsiveness of bone mass to exercise is age dependent with the prepubertal period suggested to be the most effective stage for interventions. There is a paucity of data on the effects of exercise on bone architecture and body composition when studied within the prepubertal period. We examined the effect of two forms of low-impact exercise on prepubertal changes in body composition and bone architecture. Weanling male rats were assigned to control (CON), bipedal stance (BPS), or wheel exercise (WEX) groups for 15 days until the onset of puberty. Distance travelled via WEX was recorded, food intake measured, and body composition quantified. Trabecular and cortical microarchitecture of the femur were determined by microcomputed tomography. WEX led to a higher lean mass and reduced fat mass compared to CON. WEX animals had greater femoral cortical cross-sectional thickness and closed porosity compared to CON. The different exercise modalities had no effect on body weight or food intake, but WEX significantly altered body composition and femoral microarchitecture. These data suggest that short-term mild voluntary exercise in normal prepubertal rats can alter body composition dependent upon the exercise modality.


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