scholarly journals The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

Oncotarget ◽  
2015 ◽  
Vol 6 (27) ◽  
pp. 23213-23237 ◽  
Author(s):  
Sharon E. Mitchell ◽  
Camille Delville ◽  
Penelope Konstantopedos ◽  
Jane Hurst ◽  
Davina Derous ◽  
...  
Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1879-P
Author(s):  
JOSE M. IRIMIA-DOMINGUEZ ◽  
ANDREW J. LUTKEWITTE ◽  
PATRICK T. FUEGER

2006 ◽  
Vol 25 (5) ◽  
pp. 1337 ◽  
Author(s):  
Juliana Zomer Sandrini ◽  
Francesco Regoli ◽  
Daniele Fattorini ◽  
Alessandra Notti ◽  
Alan Ferreira Inácio ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Michał Dobrakowski ◽  
Marta Boroń ◽  
Ewa Birkner ◽  
Aleksandra Kasperczyk ◽  
Ewa Chwalińska ◽  
...  

The present study was designed to explore the possible influence of subacute exposure to lead on the levels of selected essential metals, selected proteins related to them, and oxidative stress parameters in occupationally exposed workers. The study population included 36 males occupationally exposed to lead for 36 to 44 days. Their blood lead level at the beginning of the study was 10.7 ± 7.67 μg/dl and increased to the level of 49.1 ± 14.1 μg/dl at the end of the study. The levels of calcium, magnesium, and zinc increased significantly after lead exposure compared to baseline by 3%, 3%, and 8%, respectively, while the level of copper decreased significantly by 7%. The malondialdehyde (MDA) level and the activities of catalase (CAT) and superoxide dismutase (SOD) did not change due to lead exposure. However, the level of lipid hydroperoxides (LPH) in serum increased significantly by 46%, while the level of erythrocyte lipofuscin (LPS) decreased by 13%. The serum levels of essential metals are modified by a short-term exposure to lead in occupationally exposed workers. A short-term exposure to lead induces oxidative stress associated with elevated levels of LPH but not MDA.


2003 ◽  
Vol 17 (5) ◽  
pp. 454-458 ◽  
Author(s):  
Chung-Yung Jetty Lee ◽  
Minsun Kim ◽  
Sung-Won Yoon ◽  
Cherl-Ho Lee

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. SCI-2-SCI-2
Author(s):  
Rafael de Cabo

Abstract Abstract SCI-2 A prominent manifestation of aging is a reduced ability to respond to environmental stressors, including heat and oxidative stress. Reduced stress tolerance and decreased ability to maintain homeostasis are at least partially responsible for the increased morbidity and mortality that occurs with advancing age. The age-related attenuation of stress pathways and increased expression of stress-response genes with aging are examples of the growing body of evidence linking reduced stress responsiveness to aging. In 1935, McCay and colleagues first reported that reducing the caloric intake of rodents could significantly lengthen their mean and maximal life span, slowing down basic aging processes. The effect of calorie restriction (CR) on delaying aging has been replicated in many animal species including nonhuman primates, although in these, potential life span alterations cannot be ascertained for several more years due to their longevity CR causes a reduction in body weight, tissue growth, blood glucose, insulin levels and body temperature. In addition, CR prevents the age-related decline in tolerance to different stressors such as oxidative and heat, and the age-related reduction in expression of protective heat shock and oxidative stress proteins. While CR is the only intervention that has consistently been shown to increase maximum life span and prevent or delay the onset of age-associated pathophysiological changes in laboratory rodents, the underlying mechanisms remain elusive. Using calorie restriction (CR) as their benchmark research tool, gerontologists are making progress in identifying dietary and pharmacologic interventions that may be applicable to retarding aging processes in humans. Disclosures: No relevant conflicts of interest to declare.


2009 ◽  
Vol 15 (7) ◽  
pp. S166
Author(s):  
Miho Kitamura ◽  
Miyuki Kobara ◽  
Akiko Furumori ◽  
Kazuki Noda ◽  
Tatsuya Shiraishi ◽  
...  

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