scholarly journals Effects of cerebral perfusion pressure on regional cerebral blood flow in dogs with acute epidural hematoma: quantitative evaluation with contrast-enhanced ultrasound

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 93373-93381 ◽  
Author(s):  
Hongwei Cheng ◽  
Xiang Mao ◽  
Zonggang Hou ◽  
Jian Xu ◽  
Shuyu Hao ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Epidural Hematoma ◽  
Perfusion Pressure ◽  
Contrast Enhanced Ultrasound ◽  
Regional Cerebral Blood ◽  
Contrast Enhanced ◽  
Acute Epidural Hematoma

Combined SPECT Imaging of Regional Cerebral Blood Flow (99mTc-HexamethylPropyleneamine Oxime, HMPAO) and Blood Volume (99mTc-RBC) to Assess Regional Cerebral Perfusion Reserve in Patients with Cerebrovascular Disease

1988 ◽  
Vol 27 (02) ◽  
pp. 51-56 ◽  
Author(s):  
H. Braun ◽  
A. Ferbert ◽  
H. Stirner ◽  
C. Weiller ◽  
E. B. Ringelstein ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebrovascular Disease ◽  
Blood Volume ◽  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Perfusion Reserve ◽  
Promising Tool ◽  
Semiquantitative Evaluation

In 53 patients with cerebrovascular disease (CVD), regional cerebral blood flow (CBF) and blood volume (CBV) were imaged by SPECT within one session. Slice division (CBF: CBV) yielded distribution of regional cerebral perfusion reserve (CPR). Semiquantitative evaluation was obtained from manually set ROIs by interhemispherical ratios (for CBF, CBV and CPR), using 2 SD from a normal group (n = 10) as a threshold. Sensitivities were 59% for CBF, 94% for CBV and 83% for CPR. Combined sensitivity was 98%. Establishing three constellations for CBF, CBV and CPR, regionally normal CBFs but quantitatively increased CBVs (+69%) and decreased CPRs (−31 %) were found in relatively early stages of CVD. Very advanced cases showed decreased CBFs (−65%), CBVs (−40%), CPRs (−49%) and a surrounding penumbra. In 87% (46/53 patients), such Theologically postulated constellations could be demonstrated. We conclude that combined CBF and CBV SPECT, assisted by CPR images, is a promising tool to detect CVD and to assess its individual regional severity.

Altered regional cerebral blood flow in obstructive sleep apnea is associated with sleep fragmentation and oxygen desaturation

2021 ◽  
pp. 0271678X2110121
Author(s):  
Lirong Yan ◽  
Hea Ree Park ◽  
Eric J. Kezirian ◽  
Soonhyun Yook ◽  
Jae-Hun Kim ◽  
...  
Keyword(s):  
Blood Flow ◽  
Obstructive Sleep Apnea ◽  
Cerebral Blood Flow ◽  
Sleep Apnea ◽  
Default Mode Network ◽  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Attention Network ◽  
Obstructive Sleep

Altered cerebral perfusion has been reported in obstructive sleep apnea (OSA). Using dynamic susceptibility contrast MRI, we compared cerebral perfusion between male OSA patients and male healthy reference subjects and assessed correlations of perfusion abnormalities of OSA patients with sleep parameters and neuropsychological deficits at 3 T MRI, polysomnography and neuropsychological tests in 68 patients with OSA and 21 reference subjects. We found lower global and regional cerebral blood flow and cerebral blood volume, localized mainly in bilateral parietal and prefrontal cortices, as well as multiple focal cortical and deep structures related to the default mode network and attention network. In the correlation analysis between regional hypoperfusion and parameters of polysomnography, different patterns of regional hypoperfusion were distinctively associated with parameters of intermittent hypoxia and sleep fragmentation, which involved mainly parietal and orbitofrontal cortices, respectively. There was no association between brain perfusion and cognition in OSA patients in areas where significant association was observed in reference subjects, largely overlapping with nodes of the default mode network and attention network. Our results suggest that impaired cerebral perfusion in important areas of functional networks could be an important pathomechanism of neurocognitive deficits in OSA.

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