Cerebral Perfusion Pressure Correlated with Regional Cerebral Blood Flow, EEG and Aortocervical Arteriography in Patients with Severe Brain Disorders Progressing to Brain Death

1972 ◽  
Vol 8 (1-4) ◽  
pp. 207-212 ◽  
Author(s):  
P. Balslev-Jørgensen ◽  
M.P. Heilbrun ◽  
G. Boysen ◽  
A. Rosenklint ◽  
E.O. Jørgensen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Death ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Perfusion Pressure ◽  
Brain Disorders ◽  
Regional Cerebral Blood

Effects of graded hypotension on cerebral blood flow, blood volume, and mean transit time in dogs

1992 ◽  
Vol 262 (6) ◽  
pp. H1908-H1914 ◽  
Author(s):  
M. Ferrari ◽  
D. A. Wilson ◽  
D. F. Hanley ◽  
R. J. Traystman
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Perfusion Pressure ◽  
Blood Volume ◽  
Transit Time ◽  
Cerebral Perfusion ◽  
Pressure Range ◽  
Cerebral Blood Volume ◽  
Perfusion Pressure ◽  
Mean Transit Time

This study tested the hypothesis that cerebral blood flow (CBF) is maintained by vasodilation, which manifests itself as a progressive increase in mean transit time (MTT) and cerebral blood volume (CBV) when cerebral perfusion pressure is reduced. Cerebral perfusion pressure was decreased in 10 pentobarbital-anesthetized dogs by controlled hemorrhage. Microsphere-determined CBF was autoregulated in all tested cerebral regions over the 40- to 130-mmHg cerebral perfusion pressure range but decreased by 50% at approximately 30 mmHg. MTT and CBV progressively and proportionately increased in the right parietal cerebral cortex over the 40- to 130-mmHg cerebral perfusion pressure range. Total hemoglobin content (Hb1), measured in the same area by an optical method, increased in parallel with the increases in CBV computed as the (CBF.MTT) product. At 30 mmHg cerebral perfusion pressure, CBV and Hb were still increased and MTT was disproportionately lengthened (690% of control). We conclude that within the autoregulatory range, CBF constancy is maintained by both increased CBV and MTT. Outside the autoregulatory range, substantial prolongation of the MTT occurs. When CBV is maximal, further reductions in cerebral perfusion pressure produce disproportionate increases in MTT that signal the loss of cerebral vascular dilatory hemodynamic reserve.

CONTINUOUS COMPUTERIZED TRACKING DEFINES RELATIONSHIP BETWEEN CEREBRAL BLOOD FLOW, CEREBRAL PERFUSION PRESSURE AND TIME

1995 ◽  
Vol 23 (Supplement) ◽  
pp. A79
Author(s):  
George Chovanes ◽  
Michael Pasquale ◽  
Mark Cipolle ◽  
Rafael Richards ◽  
Michael Rhodes
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Perfusion Pressure

scholarly journals Physiological underpinning of default-mode network emergence in the human infant brain

2021 ◽  
Author(s):  
Qinlin Yu ◽  
Minhui Ouyang ◽  
John A. Detre ◽  
Huiying Kang ◽  
Di Hu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Default Mode Network ◽  
Regional Cerebral Blood Flow ◽  
Brain Disorders ◽  
Regional Cerebral Blood ◽  
Default Mode ◽  
Sensorimotor Network ◽  
Brain Circuit ◽  
Infant Brain

AbstractDuring infancy, rapid brain circuit maturational processes are supported by dynamic changes of regional cerebral blood flow (rCBF) to meet metabolic demands and enable functional emergence. However, the 4D spatiotemporal rCBF dynamics and mechanism of functional network emergence in infant brain are not known. Here, cutting-edge multi-modal MRI was conducted on forty-eight infants aged 0 to 24 months. With pseudo-continuous arterial-spin-labeled perfusion MRI of infants, heterogeneous age-related increases of rCBF were found across multiple vital functional network brain regions. Resting-state functional MRI revealed the characteristic default-mode network (DMN) emergence in infant brain. The rCBF increase rate is significantly higher in the DMN regions than in the reference primary sensorimotor network regions. Coupled increases of rCBF and functional connectivity specifically in the DMN were found with correlation analysis and were further confirmed by data-driven permutation tests. The 4D infant rCBF maps can be used as a quantified standard reference for assessing brain physiology in typically or atypically developmental infants. These findings from multi-modal infant MRI not only offer refreshing insights into mechanism of DMN emergence driven by higher metabolic expenditure operationalized by higher local blood supply in infant brain, but also have important implications in altered network maturation in brain disorders.SignificanceHuman infancy is characterized by rapid brain circuit maturation including default-mode network (DMN) emergence. However, the physiological underpinning of DMN emergence is unknown. Here, we established a quantified standard reference of infant regional cerebral blood flow maps and found regional cerebral blood flow increases faster in the DMN than primary sensorimotor network regions during infancy. We also found strongly coupled increases of regional cerebral blood flow and network strength specifically in the DMN, suggesting emergence of the DMN is supported by faster local blood flow increase meeting extra neuronal metabolic demands for brain circuit maturation. These results shed light on fundamental mechanism of brain network emergence and have important implications in altered network maturation in brain disorders.

Combined SPECT Imaging of Regional Cerebral Blood Flow (99mTc-HexamethylPropyleneamine Oxime, HMPAO) and Blood Volume (99mTc-RBC) to Assess Regional Cerebral Perfusion Reserve in Patients with Cerebrovascular Disease

1988 ◽  
Vol 27 (02) ◽  
pp. 51-56 ◽  
Author(s):  
H. Braun ◽  
A. Ferbert ◽  
H. Stirner ◽  
C. Weiller ◽  
E. B. Ringelstein ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebrovascular Disease ◽  
Blood Volume ◽  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Perfusion Reserve ◽  
Promising Tool ◽  
Semiquantitative Evaluation

In 53 patients with cerebrovascular disease (CVD), regional cerebral blood flow (CBF) and blood volume (CBV) were imaged by SPECT within one session. Slice division (CBF: CBV) yielded distribution of regional cerebral perfusion reserve (CPR). Semiquantitative evaluation was obtained from manually set ROIs by interhemispherical ratios (for CBF, CBV and CPR), using 2 SD from a normal group (n = 10) as a threshold. Sensitivities were 59% for CBF, 94% for CBV and 83% for CPR. Combined sensitivity was 98%. Establishing three constellations for CBF, CBV and CPR, regionally normal CBFs but quantitatively increased CBVs (+69%) and decreased CPRs (−31 %) were found in relatively early stages of CVD. Very advanced cases showed decreased CBFs (−65%), CBVs (−40%), CPRs (−49%) and a surrounding penumbra. In 87% (46/53 patients), such Theologically postulated constellations could be demonstrated. We conclude that combined CBF and CBV SPECT, assisted by CPR images, is a promising tool to detect CVD and to assess its individual regional severity.

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