scholarly journals Relationships Between Cerebral Perfusion Pressure and Regional Cerebral Blood Flow in Patients With Severe Neurological Disorders

Stroke ◽  
1972 ◽  
Vol 3 (2) ◽  
pp. 181-195 ◽  
Author(s):  
M. PETER HEILBRUN ◽  
PAUL BALSLEV JORGENSEN ◽  
GUDRUN BOYSEN
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Perfusion Pressure ◽  
Neurological Disorders ◽  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Perfusion Pressure ◽  
Regional Cerebral Blood

Effects of graded hypotension on cerebral blood flow, blood volume, and mean transit time in dogs

1992 ◽  
Vol 262 (6) ◽  
pp. H1908-H1914 ◽  
Author(s):  
M. Ferrari ◽  
D. A. Wilson ◽  
D. F. Hanley ◽  
R. J. Traystman
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Perfusion Pressure ◽  
Blood Volume ◽  
Transit Time ◽  
Cerebral Perfusion ◽  
Pressure Range ◽  
Cerebral Blood Volume ◽  
Perfusion Pressure ◽  
Mean Transit Time

This study tested the hypothesis that cerebral blood flow (CBF) is maintained by vasodilation, which manifests itself as a progressive increase in mean transit time (MTT) and cerebral blood volume (CBV) when cerebral perfusion pressure is reduced. Cerebral perfusion pressure was decreased in 10 pentobarbital-anesthetized dogs by controlled hemorrhage. Microsphere-determined CBF was autoregulated in all tested cerebral regions over the 40- to 130-mmHg cerebral perfusion pressure range but decreased by 50% at approximately 30 mmHg. MTT and CBV progressively and proportionately increased in the right parietal cerebral cortex over the 40- to 130-mmHg cerebral perfusion pressure range. Total hemoglobin content (Hb1), measured in the same area by an optical method, increased in parallel with the increases in CBV computed as the (CBF.MTT) product. At 30 mmHg cerebral perfusion pressure, CBV and Hb were still increased and MTT was disproportionately lengthened (690% of control). We conclude that within the autoregulatory range, CBF constancy is maintained by both increased CBV and MTT. Outside the autoregulatory range, substantial prolongation of the MTT occurs. When CBV is maximal, further reductions in cerebral perfusion pressure produce disproportionate increases in MTT that signal the loss of cerebral vascular dilatory hemodynamic reserve.

CONTINUOUS COMPUTERIZED TRACKING DEFINES RELATIONSHIP BETWEEN CEREBRAL BLOOD FLOW, CEREBRAL PERFUSION PRESSURE AND TIME

1995 ◽  
Vol 23 (Supplement) ◽  
pp. A79
Author(s):  
George Chovanes ◽  
Michael Pasquale ◽  
Mark Cipolle ◽  
Rafael Richards ◽  
Michael Rhodes
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Perfusion Pressure

Combined SPECT Imaging of Regional Cerebral Blood Flow (99mTc-HexamethylPropyleneamine Oxime, HMPAO) and Blood Volume (99mTc-RBC) to Assess Regional Cerebral Perfusion Reserve in Patients with Cerebrovascular Disease

1988 ◽  
Vol 27 (02) ◽  
pp. 51-56 ◽  
Author(s):  
H. Braun ◽  
A. Ferbert ◽  
H. Stirner ◽  
C. Weiller ◽  
E. B. Ringelstein ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebrovascular Disease ◽  
Blood Volume ◽  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Perfusion Reserve ◽  
Promising Tool ◽  
Semiquantitative Evaluation

In 53 patients with cerebrovascular disease (CVD), regional cerebral blood flow (CBF) and blood volume (CBV) were imaged by SPECT within one session. Slice division (CBF: CBV) yielded distribution of regional cerebral perfusion reserve (CPR). Semiquantitative evaluation was obtained from manually set ROIs by interhemispherical ratios (for CBF, CBV and CPR), using 2 SD from a normal group (n = 10) as a threshold. Sensitivities were 59% for CBF, 94% for CBV and 83% for CPR. Combined sensitivity was 98%. Establishing three constellations for CBF, CBV and CPR, regionally normal CBFs but quantitatively increased CBVs (+69%) and decreased CPRs (−31 %) were found in relatively early stages of CVD. Very advanced cases showed decreased CBFs (−65%), CBVs (−40%), CPRs (−49%) and a surrounding penumbra. In 87% (46/53 patients), such Theologically postulated constellations could be demonstrated. We conclude that combined CBF and CBV SPECT, assisted by CPR images, is a promising tool to detect CVD and to assess its individual regional severity.

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