scholarly journals The influence of oligopeptides - the homologues of ACTH15-18 on the liver and adrenal glands in the rats on the model of acute immobilization stress

2017 ◽  
Vol 15 (4) ◽  
pp. 30-37
Author(s):  
Olesya V Kudina ◽  
Sergey Yu Shtrygol’ ◽  
Aleksandr A Kolobov ◽  
Yulia B Lar’yanovska
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Adrenal Glands ◽  
Immobilization Stress ◽  
Protective Action ◽  
Antioxidant Effect ◽  
Histological Structure ◽  
Reference Drug ◽  
Depth Study ◽  
Increased Activity ◽  
Positive Effect

An in-depth study the possible links of the stress-protective action of oligopeptides - homologues of the of adrenocorticotropic hormone fragment (15-18) on the model of acute immobilization stress has been carried out. A marked antioxidant effect, not inferior to the reference medicine “Semax”, has been detected in the blood serum and liver of the rats. The results of the morphological study of liver tissue also indicate the normalization of the stress-induced damage in the organ under the influence of oligopeptides (KK-1, KK-5). Both peptides have been exceeded the reference drug, however, the peptide KK-1 had the marked positive effect on the reduction of histological structure of the liver. The stress-protective action of the investigated oligopeptides KK-1 and KK-5 is confirmed by their ability to reduce the increased activity of steroidogenesis and reduce the release of catecholamines, as well as normalize the damaged structure of the adrenal cortex. According to the indices of the adrenal structure recovering, the peptide KK-1 exceeded the reference drug and the peptide KK-1. (For citation: Kudina OV, Shtrygol’ SYu, Kolobov AA, Larjanovskaja YuB, et al. The influence of oligopeptides - the homologues of ACTH15-18 on the liver and adrenal glands in the rats on the model of acute immobilization stress. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):30-37. doi: 10.17816/RCF15430-37).

scholarly journals STUDY OF HESPERIDINE AND CURKUMIN NOOTROPIC ACTIVITY UNDER THE CONDITIONS OF FOCAL CEREBRAL ISCHEMIA

2020 ◽  
Vol 75 (3) ◽  
pp. 107-111
Author(s):  
A.V. Voronkov ◽  
◽  
S.A. Nigaryan ◽  
D.I. Pozdnyakov ◽  
◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cognitive Assessment ◽  
Focal Cerebral Ischemia ◽  
Male Rats ◽  
Avoidance Reaction ◽  
Nootropic Activity ◽  
Reference Drug ◽  
Depth Study ◽  
The Right ◽  
Positive Effect

The article presents the results of the study of the nootropic activity of hesperidin and curcumin in conditions of focal cerebral ischemia. Studies were conducted on Wistar male rats, which reproduced the focal ischemia of the right middle cerebral artery. Experimental compounds and the reference drug (Mexidol) are administered intragastrally at the next day after surgery at a dosage of 100 mg/kg for three days. Researched using memory and cognitive assessment models – the method of avoiding passive (passive avoidance reaction) and active (TEA) environments. The effect of these compounds on the level of formation of lactate, pyruvate, and the degree of necrosis was studied. Against the background of focal cerebral ischemia, hesperidin significantly improved the studied parameters, curcumin did not show a positive effect on all the studied parameters, and therefore inferior to the heotropic activity on nootropic activity. The results of experimental data suggest the possibility of further in-depth study of hesperidin for cerebroprotective and nootropic activity.

Relationship between plasma corticosterone and adrenal epinephrine after diazepam treatment in rats

1982 ◽  
Vol 60 (5) ◽  
pp. 589-596 ◽  
Author(s):  
Guy Chabot ◽  
Yves Brissette ◽  
André L. Gascon
Keyword(s):  
Adrenal Gland ◽  
Adrenal Cortex ◽  
Adrenocorticotropic Hormone ◽  
Adrenal Glands ◽  
Plasma Corticosterone ◽  
The Other ◽  
Dose Effect ◽  
Epinephrine Administration ◽  
Linear Dose ◽  
Increased Activity

Following recent observations that diazepam treatment increases adrenal epinephrine in rats, we were interested in studying the possible mechanisms of this action of diazepam on rat adrenal glands. All diazepam treatments studied (1–25 mg∙kg−1∙day−1 for 10 days) led to an increase in adrenal epinephrine following a linear dose–effect relationship. Since epinephrine synthesis is under neuronal and humoral controls, we investigated their respective importance in the effect of diazepam on the adrenal gland. The denervation of the adrenal gland did not prevent the increase in adrenal epinephrine by diazepam treatment. On the other hand, diazepam treatment was shown to cause an increase in plasma corticosterone in parallel with an increase in adrenal epinephrine. Administration of dexamethasone (a synthetic corticoid) and hypophysectomy prevented the increase in adrenal epinephrine and plasma corticosterone resulting from diazepam treatment. We thus conclude that the increase in adrenal epinephrine seen after diazepam treatment is parallel to the increase in plasma corticosterone. Moreover, since the action of diazepam on adrenal epinephrine is prevented by dexamethasone or hypophysectomy, we hypothesize that diazepam is acting on the adrenal cortex via the release of adrenocorticotropic hormone (ACTH). ACTH and corticosterone would be responsible for the increased activity of epinephrine-synthesizing enzymes in adrenal medulla.

scholarly journals Vitamin E has Protective Effects on Mice Adrenal Gland which are Exposed to Immobilization Stress

2021 ◽  
Author(s):  
FIRAT AŞIR ◽  
Yusuf Nergiz ◽  
Ayşegül Pala
Keyword(s):  
Vitamin E ◽  
Adrenal Glands ◽  
Immobilization Stress ◽  
Interstitial Fibrosis ◽  
Cortical Atrophy ◽  
Control Group ◽  
Histological Structure ◽  
Protective Effects ◽  
Stress Group ◽  
Hematoxylin Eosin

Abstract Background To investigate the protective effect of vitamin E on mice adrenal glands in immobilization stress and to examine post-stress behavioral changes. Twenty-eight male, 10-week-old, BALB/C mice weighing 30 grams were divided into four groups. Mice were placed in a cage where no movement was allowed 6 hours/day for 7 days for immobilization stress. 0.1ml saline was administered to the control group and the stress group for 7 days, whereas 30 mg/kg/day vitamin E was administered orogastrically 1 hour before immobilization stress in the vitamin E and stress + vitamin E group. At the end of the 7th day, all animals were subjected to open field, elevated-plus maze (anxiety) and forced swimming (depression) tests. Left adrenal glands were dissected for routine paraffin tissue protocol. Sections were stained with hematoxylin-eosin and Azan. Malonaldehyde (MDA) levels were also measured in the adrenal tissues. Results Anxiety symptoms were not significant between groups (0.582). Depression level (p = 0.024) and MDA values (p = 0.01) were the highest in the stress group, which was significantly higher than that of the vitamin E group. In the hematoxylin-eosin sections of the stress group, cortical atrophy, medullary hypertrophy, dilated capillaries, and hemorrhage were observed. Azan staining revealed a thinned capsule, cortical fibrosis, and intense fibrosis in the stress group. Histological structure was protected in the stress + vitamin E group, but dilatation and interstitial fibrosis were also detected. Conclusion Immobilization stress may cause some psychopharmacological, morphometric, and histopathologic changes in mouse adrenal glands, and vitamin E may largely protect the gland from these effects.

scholarly journals Violation of some parameters of pigment and lipid metabolism in experimental pneumonia in immobilization stress and their correction by corvitin

2015 ◽  
Vol 17 (2) ◽  
Author(s):  
N. М. Ferents
Keyword(s):  
Lipid Metabolism ◽  
Functional State ◽  
Liver Damage ◽  
Immobilization Stress ◽  
Negative Impact ◽  
Research Results ◽  
Experimental Pneumonia ◽  
Positive Effect

<p>Research results have shown the liver damage in terms of EP and IS in violation of its functional state. High<br />levels of bilirubin and cholesterol suggests the existence of violation of integrity hepatocytes syndrome which is<br />caused by the negative impact of VC in terms of IS . Using the domestic drug “Corvitin”, resulted in a significant<br />decrease in the changed parameters of bilirubin and cholesterol under conditions of formation of EP and IP , indicating<br />its positive effect adjustment.</p>

scholarly journals MORPHOFUNCTIONAL STATE OF THE ADRENAL GLANDS IN LABORATORY ANIMALS UNDER EXPERIMENTAL INTOXICATION WITH CYPERMETHRIN

2018 ◽  
pp. 28-33
Author(s):  
E. A. Chigrinsky ◽  
V. D. Konvay ◽  
Yu. N. Fedorov ◽  
L. K. Gerunova ◽  
V. I. Gerunov
Keyword(s):  
Blood Serum ◽  
Adrenocorticotropic Hormone ◽  
Adrenal Glands ◽  
Control Level ◽  
Male Rats ◽  
Acute Intoxication ◽  
Laboratory Animals ◽  
Chronic Intoxication ◽  
Adrenal Tissue ◽  
Morphological Criteria

The research objective was to evaluate the morphofunctional state of the adrenal glands in laboratory animals in conditions of acute and chronic intoxication with cypermethrin. Studies were performed on 140 male rats of the Wistar line. To simulate an acute intoxication cypermethrin was single injected into the stomach in a dose of half of LD50 followed by observation of the animals for 30 days. In the study of chronic intoxication cypermethrin was administered to rats in a dose of 1/100 of LD50. The experiment has lasted for 120 days.At the initial stage of the experiment the acute intoxication of rats with cypermethrin caused hyper- and then hyposecretion of adrenocorticotropic hormone. The content of progesterone in the blood serum and adrenal tissue decreased in animals. During the first three days after the poisoning there was an increase in the concentration of corticosterone in the blood serum. To the end of the 7th day the concentration of this hormone in adrenal tissue decreased sharply and did not reach the control background after a month. Chronic intoxication with cypermethrin caused hypersecretion of adrenocorticotropic hormone for two months with the subsequent normalization of its level in the blood. The disturbance of progesterone synthesis in the adrenal glands during chronic intoxication is indicated by fluctuation of its concentration in blood 30 days after the start of the experiment. There was found high level of corticosterone in blood and adrenal glands for two months, and then it decreased to a control level. Morphological criteria for amplification and then suppression of adrenal function are the dimension of endocrine cells and their nuclei, the intensity of cell vacuolation suggesting the degree of lipids accumulation, and the severity of blood filling in the vessels of the beam and reticular zones.

ASSOCIATION BETWEEN APE1 GENE AND LUNG CANCER IN IRAQI POPULATION

2021 ◽  
Vol 74 (9) ◽  
pp. 2255-2258
Author(s):  
Mustafa Mamon Ahmed
Keyword(s):  
Lung Cancer ◽  
Protective Action ◽  
Control Group ◽  
Increased Activity ◽  
Ape1 Asp148glu

The aim: To find association between ape1 gene and lung cancer in Iraqi population. Materials and methods: This study included forty patients with lung cancer and forty people of control group, ranging in age from 40 to 65 years old. Results: The results of (Asp/Glu) genotype showed a significant (p=<0.01) higher frequency in patients than in control group carrying the (Asp/Asp). Conclusions: APE1 Asp148Glu polymorphism may bear a risk for development of the lung cancer in Iraqi patients, and the Asp/Glu genotype contributed to more often predisposal of the disease by playing an important role as increased activity of gene as a result of APE1 Asp148Glu (rs1130409) polymorphism, while Asp/Asp genotype may have a protective action against this disease.

scholarly journals Nanoparticles of activated natural zeolite on textiles for protection and therapy

2009 ◽  
Vol 15 (4) ◽  
pp. 203-210 ◽  
Author(s):  
Ana Grancaric ◽  
Anita Tarbuk ◽  
Ivancica Kovacek
Keyword(s):  
Small Molecules ◽  
Natural Zeolite ◽  
Catalytic Properties ◽  
Antioxidant Effect ◽  
Healing Wounds ◽  
The Common ◽  
Living Organisms ◽  
Positive Effect ◽  
Agriculture Water ◽  
Protective Textiles

Activated natural zeolite clinoptilolite is microporous hydrated aluminosilicates crystals with well-defined structures containing AlO4 and SiO4 tetrahedral linked through the common oxygen atoms. It is to point out that zeolites act as strong adsorbents and ion-exchangers but having many other useful properties. Due to its cationexchange ability, zeolites have catalytic properties and, for that, multiple uses in medicine and industry, agriculture, water purification and detergents. Zeolites are nontoxic substance, excellent for UVR and microbes protection, for proteins and small molecules such as glucose adsorption. In this paper its positive effect on the metabolism of living organisms and its anticancerogenic, antiviral, antimetastatic and antioxidant effect. The activity of natural zeolite as natural immunostimulator was presented as well as its help in healing wounds. Therefore, the present paper is an attempt to modify cotton (by mercerization) and polyester (by alkaline hydrolysis) fabrics for summer clothing with addition of natural zeolite nanoparticles for achieving UV and antibacterial protective textiles.

Hypoadrenocorticism in two cats successfully treated with desoxycorticosterone pivalate

2018 ◽  
Vol 6 (3) ◽  
pp. e000600
Author(s):  
Franziska Reimann ◽  
Stefanie Siol ◽  
Charlotte Schlüter ◽  
Reto Neiger
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Adrenal Glands ◽  
Final Concentration ◽  
Stimulation Test ◽  
Acth Stimulation Test ◽  
Acth Stimulation ◽  
Blood Examination ◽  
Stimulation Of

Two cats were presented with lethargy and anorexia. Clinically, the cats showed hypothermia and dehydration. Blood examination in both cats showed hyponatraemia, hyperkalaemia and additionally azotaemia in case 1 and hypercalcaemia in case 2. In both cats, an adrenocorticotropic hormone (ACTH) stimulation test showed an insufficient stimulation of the adrenal glands. In case 1, markedly elevated endogenous ACTH was additionally measured. Both cats were successfully treated with a combination of desoxycorticosterone pivalate (DOCP) and prednisolone (0.15 mg/kg daily). Case 1 received a final concentration of 2.6 mg/kg DOCP every 30 days, while case 2 was successfully managed with 2.2 mg/kg every 28 days. These rare cases of feline hypoadrenocorticism demonstrate that DOCP can be used similarly as in dogs.

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