Antioxidant effect of cytochromec under conditions of prolonged immobilization stress

1997 ◽  
Vol 123 (6) ◽  
pp. 559-561 ◽  
Author(s):  
A. V. Zor'kina ◽  
V. I. Inchina ◽  
Ya. V. Kostin
Keyword(s):  
Immobilization Stress ◽  
Antioxidant Effect ◽  
Prolonged Immobilization

scholarly journals Activity of endogenous aldehydes catabolism enzymes in subcellular fractions of liver, heart and brain of rats at pubertal age under stress

2012 ◽  
Vol 58 (6) ◽  
pp. 691-701
Author(s):  
L.L. Sukhova ◽  
A.V. Guryeva ◽  
E.A. Berezhnaya ◽  
V.V. Davydov
Keyword(s):  
Aldehyde Dehydrogenase ◽  
Rat Heart ◽  
Immobilization Stress ◽  
Mitochondrial Fraction ◽  
Subcellular Fractions ◽  
Brain Cells ◽  
Redox Transformation ◽  
Effective Utilization ◽  
Old Rats ◽  
Prolonged Immobilization

Activities of enzymes involved in redox transformation of endogenous aldehydes have been investigated in subcellular fractions of liver, heart, and brain of pubertal rats exposed to prolonged immobilization stress. In the liver aldo-keto reductase (AKR) activity in the postmitochondrial fraction and aldehyde dehydrogenase (ALDH) acivity of the mitochondrial fraction demonstrated a more pronounced decrease in 2-month-old rats. Rat heart postmitochondrial AKR and ALDH demonstrated opposite changes in their enzymatic activities, while activity of mitochondrial ALDH remained unchanged. Brain cells create conditions that favor effective utilization of endogenous aldehydes in metabolic redox pathways.

scholarly journals The influence of oligopeptides - the homologues of ACTH15-18 on the liver and adrenal glands in the rats on the model of acute immobilization stress

2017 ◽  
Vol 15 (4) ◽  
pp. 30-37
Author(s):  
Olesya V Kudina ◽  
Sergey Yu Shtrygol’ ◽  
Aleksandr A Kolobov ◽  
Yulia B Lar’yanovska
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Adrenal Glands ◽  
Immobilization Stress ◽  
Protective Action ◽  
Antioxidant Effect ◽  
Histological Structure ◽  
Reference Drug ◽  
Depth Study ◽  
Increased Activity ◽  
Positive Effect

An in-depth study the possible links of the stress-protective action of oligopeptides - homologues of the of adrenocorticotropic hormone fragment (15-18) on the model of acute immobilization stress has been carried out. A marked antioxidant effect, not inferior to the reference medicine “Semax”, has been detected in the blood serum and liver of the rats. The results of the morphological study of liver tissue also indicate the normalization of the stress-induced damage in the organ under the influence of oligopeptides (KK-1, KK-5). Both peptides have been exceeded the reference drug, however, the peptide KK-1 had the marked positive effect on the reduction of histological structure of the liver. The stress-protective action of the investigated oligopeptides KK-1 and KK-5 is confirmed by their ability to reduce the increased activity of steroidogenesis and reduce the release of catecholamines, as well as normalize the damaged structure of the adrenal cortex. According to the indices of the adrenal structure recovering, the peptide KK-1 exceeded the reference drug and the peptide KK-1. (For citation: Kudina OV, Shtrygol’ SYu, Kolobov AA, Larjanovskaja YuB, et al. The influence of oligopeptides - the homologues of ACTH15-18 on the liver and adrenal glands in the rats on the model of acute immobilization stress. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):30-37. doi: 10.17816/RCF15430-37).

ACTH, corticosterone, and ?-endorphin in rat blood plasma after prolonged immobilization stress

1985 ◽  
Vol 100 (2) ◽  
pp. 1026-1029 ◽  
Author(s):  
E. A. Kiyatkin ◽  
Yu. V. Polyntsev ◽  
N. E. Kushlinskii ◽  
M. G. Amiragova
Keyword(s):  
Blood Plasma ◽  
Immobilization Stress ◽  
Rat Blood ◽  
Prolonged Immobilization

Antioxidant and hypolipidemic properties of mexidol and emoxypine during prolonged immobilization stress

1998 ◽  
Vol 32 (5) ◽  
pp. 231-233
Author(s):  
A. V. Zor'kina ◽  
Ya. V. Kostin ◽  
V. I. Inchina ◽  
L. N. Sernov ◽  
L. D. Smirnov
Keyword(s):  
Immobilization Stress ◽  
Prolonged Immobilization

scholarly journals EFFECT OF LONG-TERM VAGOTONIA ON STRUCTURAL CHANGES IN THE WALL OF ABDOMINAL AORTA DURING IMMOBILIZATION STRESS IN EXPERIMENTAL STUDY

2018 ◽  
Vol 18 (4) ◽  
pp. 97-102
Author(s):  
S.V. Gavreliuk ◽  
S.V. Levenets
Keyword(s):  
Abdominal Aorta ◽  
Wistar Rats ◽  
Structural Changes ◽  
Immobilization Stress ◽  
Prolonged Exposure ◽  
Vascular Wall ◽  
Morphological Data ◽  
Elastic Membrane ◽  
Prolonged Immobilization

This work covers current questions on studying structural changes in the wall of the abdominal aorta during the modelled long-term immobilization stress against vagotonia. The purpose of this study was to reveal the effect of prolonged vagotonia on the structure of the wall of the abdominal aorta in rats in the experiment. The studies were performed on three comparable groups of hundred-day Wistar rats, which were exposed to immobilization stress and vagotonia for a period of 10 days. Immobilization was chosen as a method to induce stress model. The rats were placed into a special plastic box, in this way limiting their movements for four hours at room temperature.  Vagotonia was modelled by the administration of pyridostigmine bromide, reversible anticholinesterase. Histological preparations of the abdominal aorta were studied by x40, x100, x400 magnification using the Primo Star 5 microscope (Carl Zeiss, FRG) followed by photography of microscopic images. Computer morphometry was performed with x100 and x400 magnification and then the image were displayed on the computer monitor using the DVR and AxioVision image analysis software (Rel.4.8.2) in μm. We assessed the thickness of the subendothelial layer, and namely an internal elastic membrane and media. The ratio of the extent of the abdominal aorta lumen to the vascular wall was calculated in the Adobe Photoshop program by the A. A. Glagoliev method through overlaying of point grids on sections, the results were converted into percentages. The studies were carried out in five fields of five different sections in each rat. The results of the variation analysis of the morphological data obtained have revealed some features of restructuring the vascular wall of the abdominal aorta due to prolonged immobilization stress accompanied by vagotonia. It has been found out that prolonged exposure of  hundred-day Wistar rats to immobilization stress leads to a decrease in thickness and certain morphological changes in all layers of the abdominal aorta wall and a decrease in the percentage of the component of the vessel wall. When accompanied by prolonged immobilization and vagotonia, preservation of the endothelial layer of the abdominal aorta was observed against the background of a decrease in intimal thickness and degenerative cell changes, as well as media thickening and focal changes in adventitia.

Morphofunctional Feature in Experimental Myocardial Damage Heart on the Background of Diabetes and Cytoprotector

10.12737/2735 ◽  
2013 ◽  
Vol 20 (4) ◽  
pp. 78-82
Author(s):  
Блинов ◽  
Dmitry Blinov ◽  
Елизарова ◽  
Yu. Elizarova ◽  
Сингх ◽  
...  
Keyword(s):  
Immobilization Stress ◽  
Myocardial Hypertrophy ◽  
Water Solution ◽  
Venous Blood ◽  
Myocardial Damage ◽  
Acute Ischemia ◽  
Insulin Dependent ◽  
Prolonged Immobilization ◽  
Destructive Processes ◽  
Ischemic Stress

The article highlights the experiments on white mice and purebred cats, which simulated insulin-dependent diabetes by intra-abdominal injection of water solution streptozotocin in the dose of 15 mg/kg, which destroys (3-cells of the pancreas within 14 days and leads to increased blood glucose animals by 70-80% compared with intact animals. In the experiment, the authors studied the derivative of L-glutamic acid deanol aceglumate at the preventive intragastric introduction, which showed the presence of cardioprotec-tive effect in the animals with ischemic, stress and metabolic damage to the heart. This was expressed in the reduction of deaths mice with diabetes subjected to 25% immobilization stress in the period of 28 days, and in improving the adaptation of animals to prolonged immobilization. The data obtained are confirmed by the absence of reducing the weight of the animals during the experiment, an obstacle to development of relative and absolute myocardial hypertrophy, lack of pronouced destructive processes in the contractile car-diomyocytes left stomach animals, increased life expectancy, animals when modeling adrenaline micronecrosis in mice with diabetes, improving gas and acid-base composition of venous blood outflow from ischemia heart cats with acute ischemia and diabetes.

Sperm Quality and Fertility Following Prolonged Immobilization Stress in Wistar Rats

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
OE Mesembe ◽  
AO Igiri ◽  
VA Fischer ◽  
SA Bisong ◽  
VS Ekam
Keyword(s):  
Wistar Rats ◽  
Immobilization Stress ◽  
Sperm Quality ◽  
Prolonged Immobilization
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