Pyramidone action on carbohydrate metabolism

1934 ◽  
Vol 30 (7-8) ◽  
pp. 784-784
Author(s):  
G. Krause ◽  
H. Marx
Keyword(s):  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
High Fever

The accidental observation of a severely diabetic with furunculosis and high fever, where after giving pyramidon, in addition to a drop in t, a drop in blood sugar was observed for several days, served G. Krause and H. Marx the reason for a more detailed study of the action of Pyramidon, on healthy and diabetic persons.

STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN INFANT

PEDIATRICS ◽  
1967 ◽  
Vol 40 (1) ◽  
pp. 69-77
Author(s):  
Rosita S. Pildes ◽  
Audrey E. Forbes ◽  
Marvin Cornblath
Keyword(s):  
Blood Glucose ◽  
Carbohydrate Metabolism ◽  
Birth Order ◽  
Blood Sugar ◽  
Newborn Infant

Blood sugar determinations were done during the first 5 days of life on 100 sets of twins. Hypoglycemia was found in the smaller member in 8 of 11 pairs who were discordant by more than 25% with the smaller twin weighing less than 2.0 kg. Hypoglycemia occurred in one other pair of the remaining 89 sets of twins. Blood glucose values were not influenced by the birth order or the sex of the infants. Infants who weighed over 2,500 gm had significantly higher blood sugars than those who weighed below 2,500 gm.

Effect of septacrol'u (acridine derivative) on blood sugar in various patients with normal carbohydrate metabolism and in diabetics

1929 ◽  
Vol 25 (5) ◽  
pp. 577-577
Author(s):  
Z. Blumstein
Keyword(s):  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Acridine Derivative ◽  
The Right

Otto Jul Nielsen (Acta medica Scandinavica, Vol. LXX (1929), fase. 1) investigated the effect of septacrol'u (acridine derivative) on blood sugar in various patients with normal carbohydrate metabolism and in diabetics. Septacrol was administered intravenously at 5 kbp. with. In the first cases, the amount of sugar in the blood did not change, and secondly, it is true, there was some decrease, but in magnitude it did not exceed those figures that were obtained in the study of blood sugar in starving patients. These results give N'y the right to consider the action of septacrol to be sharply different from the action of insulin

Blood-Sugar Studies in Mental Disorders

1925 ◽  
Vol 71 (294) ◽  
pp. 443-473 ◽  
Author(s):  
S. A. Mann
Keyword(s):  
Mental Disorders ◽  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
General Paralysis ◽  
Common Experience

It is a common experience in the investigation of mental disorders that glycosuria is frequently found, thus indicating a tendency in such cases to a faulty carbohydrate metabolism. With the exception of epilepsy, this occurrence of glycosuria has been noted in most mental conditions. Intermittent glycosuria is met with in general paralysis (Kraepelin) (1); Bond (2) and Strauss (3) note it in about 10 per cent. of their cases. In dementia prócox Schultze and Knauer (4) did not observe glycosuria in the apathetic form of hebephrenia, but often found it to occur with catatonic excitement. With other observers (see Allers (5)) they record the marked association of glycosuria with depressed states, while its occurrence in mania was infrequent except in markedly excited and resistive cases.

Effects of Epinephrine on Carbohydrate Metabolism in Underfed and ad Libitum-Fed Rats

1957 ◽  
Vol 190 (2) ◽  
pp. 239-242
Author(s):  
B. N. Spirtos ◽  
R. G. Stuelke ◽  
N. S. Halmi
Keyword(s):  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Blood Lactate ◽  
Liver Glycogen ◽  
Hepatic Glycogen ◽  
Commercial Diet ◽  
Ad Libitum ◽  
Sugar Levels ◽  
Fasted Rats

Rats fed 10 gm of a commercial diet for 4–5 weeks and fasted for 24 hours showed less rise in liver glycogen and blood sugar levels in response to the injection of epinephrine than did ad libitum-fed-fasted rats. Gastrocnemius glycogen levels were found to be higher in underfed-fasted animals and fell to the same extent as in ad libitum fed-fasted animals when epinephrine was given. Blood lactate concentrations, however, rose less markedly in the underfed-fasted group. This may have been at least partly responsible for the diminished rise in hepatic glycogen and blood sugar.

Salivary Glucose Threshold

1958 ◽  
Vol 192 (3) ◽  
pp. 482-484 ◽  
Author(s):  
L. L. Langley ◽  
C. H. Gunthorpe ◽  
W. A. Beall
Keyword(s):  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Fasting Blood Sugar ◽  
Parotid Saliva ◽  
Permeability Function ◽  
Diabetic Dogs ◽  
Glucose Threshold

There is no glucose in the parotid saliva of normal, untreated dogs. Glucose appears in the saliva when the blood sugar is elevated to about 512 mg%. If insulin is given along with the infusion of glucose, the threshold is elevated to approximately 1235 mg%. Conversely, in alloxan diabetic dogs there is glucose in the saliva at the fasting blood sugar level. In this series that level averaged 269 mg%. Apparently the passage of glucose from the blood to the saliva is more than a simple permeability function. Glandular intracellular carbohydrate metabolism may be involved.

Some Observations on the Types of Blood-Sugar Curve found in Different Forms of Insanity

1925 ◽  
Vol 71 (292) ◽  
pp. 8-29 ◽  
Author(s):  
K. K. Drury ◽  
C. Farran-Ridge
Keyword(s):  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Sugar Content ◽  
Blood Sugar Curve ◽  
Sugar Tolerance

The object of our investigations has been to find out if carbohydrate metabolism is disordered in the different forms of insanity.To this end we have determined the sugar tolerance of 100 insane patients by observing the variations in the blood-sugar content after the ingestion of a known amount of glucose.

STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN

PEDIATRICS ◽  
1956 ◽  
Vol 18 (2) ◽  
pp. 167-176
Author(s):  
Marvin Cornblath ◽  
Ephraim Y. Levin ◽  
Harry H. Gordon
Keyword(s):  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Newborn Infants ◽  
Capillary Blood ◽  
Homeostatic Mechanisms

Capillary-venous differences in concentrations of blood sugar were measured in 55 newborn infants during the first 15 hours of life. The capillary-venous difference is related to the capillary level under fasting conditions. The administration of glucose by gavage in doses of 2 to 3 gm./kg. led to a prompt rise in concentration of glucose in capillary blood and an increase in capillary-venous difference. The administration of .03 µg./kg. of epinephrine led to a prompt increase in concentration of glucose in capillary blood but to a decrease in the capillary-venous difference. The relation of these findings to homeostatic mechanisms in the newborn was discussed.

FURTHER STUDIES ON CARBOHYDRATE METABOLISM IN THE VITAMIN-B6-DEPRIVED RAT

1955 ◽  
Vol 33 (2) ◽  
pp. 161-166 ◽  
Author(s):  
John R. Beaton
Keyword(s):  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Muscle Glycogen ◽  
Vitamin B6 ◽  
Liver Glycogen ◽  
Inorganic Phosphorus ◽  
Vitamin B ◽  
Insulin Administration ◽  
Elevated Blood ◽  
Sugar Levels

Earlier studies in this laboratory demonstrated abnormalities in carbohydrate metabolism in the vitamin-B6-deprived rat. The results of further studies are reported in this communication. Following three weeks of vitamin B6 restriction, rats have significantly elevated levels of inorganic phosphorus and glutathione in blood and liver. These elevations in blood inorganic phosphorus and glutathione levels have been similarly demonstrated after only one week of vitamin B6 deprivation. Contrary to changes in liver glycogen levels, muscle glycogen levels are not altered by vitamin B6 deprivation in the rat. Insulin administration had a slightly more pronounced effect on blood sugar levels in vitamin-B6-deprived than in pair-fed control rats. Alloxan administration elevated blood sugar levels of deprived rats to a slightly greater extent than the levels of controls. In accord with the earlier studies, disturbances of carbohydrate metabolism can be readily demonstrated in vitamin-B6-deprived rats.

scholarly journals Studies on carbohydrate metabolism. I.—Variations in the nature of the blood sugar

1924 ◽  
Vol 97 (680) ◽  
pp. 20-40 ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Potassium Permanganate ◽  
Optical Rotation ◽  
Reducing Power ◽  
Normal Blood ◽  
Definite Evidence ◽  
Potassium Permanganate Solution ◽  
Stable Type

In a previous paper (1) it was shown that marked differences exist between the blood sugar of normal persons and those suffering iron diabetes mellitus. The sugar was extracted from considerable quantities of blood (usually 50 to 100 c. c.) by the method previously described. A comparison was then made between the observed optical rotation (P) and that calculated from the reducing power of the carbohydrate on the basis that glucose is the only reducing substance present. The latter factor is referred to in the text as (C). In the case of normal blood sugar the initial low value of P compared with C, together with the fact that it decolorises potassium permanganate solution indicate that the sugar does not belong to the normal stable type of glucose. In view of the work of Hewitt and Pryde (2) it was suggested that this sugar might be γ -glucose, although the evidence submitted by these authors is by no means conclusive (3). There is as yet no definite evidence available as to the nature of normal blood sugar. In investigating this subject we have undertaken an examination of the variations in the ratio P/C which ensue under varying conditions and our results are described in the following paper.

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