Cardiac Stem Cells in Brown Adipose Tissue Express CD133 and Induce Bone Marrow Nonhematopoietic Cells to Differentiate into Cardiomyocytes

Stem Cells ◽  
2007 ◽  
Vol 25 (5) ◽  
pp. 1326-1333 ◽  
Author(s):  
Yoshihiro Yamada ◽  
Shin-ichiro Yokoyama ◽  
Xiang-Di Wang ◽  
Noboru Fukuda ◽  
Nobuyuki Takakura
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cardiac Stem Cells ◽  
Brown Adipose

scholarly journals Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Enrique Calvo ◽  
Noelia Keiran ◽  
Catalina Núñez-Roa ◽  
Elsa Maymó-Masip ◽  
Miriam Ejarque ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Therapeutic Option ◽  
Metabolic Activation ◽  
Diet Induced Obesity ◽  
Brown Adipose ◽  
Obesity In Mice ◽  
Treatment Of Obesity ◽  
Visceral Adipose

AbstractAdipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. Despite the recent identification of brown adipose tissue (BAT) as a potential target in the management of obesity, the use of ASCs isolated from BAT as a therapy for patients with obesity has not yet been explored. Metabolic activation of BAT has been shown to have not only thermogenic effects, but it also triggers the secretion of factors that confer protection against obesity. Herein, we isolated and characterized ASCs from the visceral adipose tissue surrounding a pheochromocytoma (IB-hASCs), a model of inducible BAT in humans. We then compared the anti-obesity properties of IB-hASCs and human ASCs isolated from visceral white adipose tissue (W-hASCs) in a murine model of diet-induced obesity. We found that both ASC therapies mitigated the metabolic abnormalities of obesity to a similar extent, including reducing weight gain and improving glucose tolerance. However, infusion of IB-hASCs was superior to W-hASCs in suppressing lipogenic and inflammatory markers, as well as preserving insulin secretion. Our findings provide evidence for the metabolic benefits of visceral ASC infusion and support further studies on IB-hASCs as a therapeutic option for obesity-related comorbidities.

Transient overexpression of Pparγ2 and C/ebpα in mesenchymal stem cells induces brown adipose tissue formation

2013 ◽  
Vol 8 (3) ◽  
pp. 295-308 ◽  
Author(s):  
Dmitriy Sheyn ◽  
Gadi Pelled ◽  
Wafa Tawackoli ◽  
Susan Su ◽  
Shiran Ben-David ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Tissue Formation ◽  
Brown Adipose ◽  
Transient Overexpression

scholarly journals Incidental brown adipose tissue in bone marrow biopsy

Blood ◽  
2017 ◽  
Vol 130 (7) ◽  
pp. 952-952 ◽  
Author(s):  
Jennifer Chapman ◽  
Francisco Vega
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Bone Marrow Biopsy ◽  
Brown Adipose

scholarly journals Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes

Bone ◽  
2012 ◽  
Vol 50 (2) ◽  
pp. 546-552 ◽  
Author(s):  
A. Krings ◽  
S. Rahman ◽  
S. Huang ◽  
Y. Lu ◽  
P.J. Czernik ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Marrow Fat ◽  
Bone Marrow Fat ◽  
Brown Adipose ◽  
Tissue Characteristics

scholarly journals Metabolically Active Three-Dimensional Brown Adipose Tissue Engineered from White Adipose-Derived Stem Cells

2017 ◽  
Vol 23 (7-8) ◽  
pp. 253-262 ◽  
Author(s):  
Jessica P. Yang ◽  
Amy E. Anderson ◽  
Annemarie McCartney ◽  
Xavier Ory ◽  
Garret Ma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Three Dimensional ◽  
Adipose Derived Stem Cells ◽  
Brown Adipose

Human metabolically active brown adipose tissue derived stem cells

Cytotherapy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. S69
Author(s):  
F. Silva ◽  
D. Holt ◽  
V. Vargas ◽  
D. Bull ◽  
A.N. Patel
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose

Tbx18-dependent differentiation of brown adipose tissue-derived stem cells toward cardiac pacemaker cells

2017 ◽  
Vol 433 (1-2) ◽  
pp. 61-77 ◽  
Author(s):  
Lei Chen ◽  
Zi-Jun Deng ◽  
Jian-Sheng Zhou ◽  
Rui-Juan Ji ◽  
Xi Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cardiac Pacemaker ◽  
Pacemaker Cells ◽  
Brown Adipose

scholarly journals Seasonal Changes in Endocannabinoid Concentrations between Active and Hibernating Marmots (Marmota flaviventris)

2018 ◽  
Vol 33 (4) ◽  
pp. 388-401 ◽  
Author(s):  
Emily A. Mulawa ◽  
Jay S. Kirkwood ◽  
Lisa M. Wolfe ◽  
Samantha J. Wojda ◽  
Jessica E. Prenni ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Energy Metabolism ◽  
Brown Adipose Tissue ◽  
Cortical Bone ◽  
White Adipose Tissue ◽  
Endocannabinoid System ◽  
Negative Consequences ◽  
Marmota Flaviventris ◽  
Brown Adipose

Hibernation is a naturally occurring model for studying diseases such as obesity and osteoporosis. Hibernators, marmots (Marmota flaviventris) among them, are able to nearly double their body mass by increasing fat stores prior to hibernation without the negative consequences of obesity. They are also physically inactive for extended periods of time without experiencing negative effects on the skeleton. The endocannabinoid system is involved in modulating neural signaling, circannual rhythms, behavior, appetite, thermogenesis, and bone and energy metabolism. These systems are also altered to maintain homeostasis during hibernation. This study aims to better understand the involvement of the endocannabinoid system in the regulation of physiological processes during hibernation by quantifying the seasonal variation of endocannabinoids and endocannabinoid-like ligands in both active and hibernating marmots. We hypothesized that there would be significant changes in endocannabinoid concentrations at the tissue level in marmots between active and hibernating states. Concentrations were measured in brain, serum, brown adipose tissue, white adipose tissue, bone marrow, cortical bone, and trabecular bone using microflow chromatography coupled with tandem quadrupole mass spectrometry. Significant changes were found, such as a 30-fold decrease in 2-arachidonoyl glycerol (2-AG) in cortical bone during hibernation. Many endocannabinoid and endocannabinoid-like ligands decreased in brown adipose tissue, white adipose tissue, and cortical bone, while several ligands increased in bone marrow. This result supports our hypothesis and suggests the possibility of a peripherally controlled shift in energy metabolism, reduction in bone metabolism, and suppression of the immune system during hibernation.

scholarly journals Metabolically Active Human Brown Adipose Tissue Derived Stem Cells

Stem Cells ◽  
2014 ◽  
Vol 32 (2) ◽  
pp. 572-581 ◽  
Author(s):  
Francisco J Silva ◽  
Dolly J Holt ◽  
Vanessa Vargas ◽  
James Yockman ◽  
Sihem Boudina ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose
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