scholarly journals Metabolically Active Human Brown Adipose Tissue Derived Stem Cells

Stem Cells ◽  
2014 ◽  
Vol 32 (2) ◽  
pp. 572-581 ◽  
Author(s):  
Francisco J Silva ◽  
Dolly J Holt ◽  
Vanessa Vargas ◽  
James Yockman ◽  
Sihem Boudina ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose

scholarly journals Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Enrique Calvo ◽  
Noelia Keiran ◽  
Catalina Núñez-Roa ◽  
Elsa Maymó-Masip ◽  
Miriam Ejarque ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Therapeutic Option ◽  
Metabolic Activation ◽  
Diet Induced Obesity ◽  
Brown Adipose ◽  
Obesity In Mice ◽  
Treatment Of Obesity ◽  
Visceral Adipose

AbstractAdipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. Despite the recent identification of brown adipose tissue (BAT) as a potential target in the management of obesity, the use of ASCs isolated from BAT as a therapy for patients with obesity has not yet been explored. Metabolic activation of BAT has been shown to have not only thermogenic effects, but it also triggers the secretion of factors that confer protection against obesity. Herein, we isolated and characterized ASCs from the visceral adipose tissue surrounding a pheochromocytoma (IB-hASCs), a model of inducible BAT in humans. We then compared the anti-obesity properties of IB-hASCs and human ASCs isolated from visceral white adipose tissue (W-hASCs) in a murine model of diet-induced obesity. We found that both ASC therapies mitigated the metabolic abnormalities of obesity to a similar extent, including reducing weight gain and improving glucose tolerance. However, infusion of IB-hASCs was superior to W-hASCs in suppressing lipogenic and inflammatory markers, as well as preserving insulin secretion. Our findings provide evidence for the metabolic benefits of visceral ASC infusion and support further studies on IB-hASCs as a therapeutic option for obesity-related comorbidities.

Cardiac Stem Cells in Brown Adipose Tissue Express CD133 and Induce Bone Marrow Nonhematopoietic Cells to Differentiate into Cardiomyocytes

Stem Cells ◽  
2007 ◽  
Vol 25 (5) ◽  
pp. 1326-1333 ◽  
Author(s):  
Yoshihiro Yamada ◽  
Shin-ichiro Yokoyama ◽  
Xiang-Di Wang ◽  
Noboru Fukuda ◽  
Nobuyuki Takakura
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cardiac Stem Cells ◽  
Brown Adipose

Transient overexpression of Pparγ2 and C/ebpα in mesenchymal stem cells induces brown adipose tissue formation

2013 ◽  
Vol 8 (3) ◽  
pp. 295-308 ◽  
Author(s):  
Dmitriy Sheyn ◽  
Gadi Pelled ◽  
Wafa Tawackoli ◽  
Susan Su ◽  
Shiran Ben-David ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Tissue Formation ◽  
Brown Adipose ◽  
Transient Overexpression

scholarly journals Metabolically Active Three-Dimensional Brown Adipose Tissue Engineered from White Adipose-Derived Stem Cells

2017 ◽  
Vol 23 (7-8) ◽  
pp. 253-262 ◽  
Author(s):  
Jessica P. Yang ◽  
Amy E. Anderson ◽  
Annemarie McCartney ◽  
Xavier Ory ◽  
Garret Ma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Three Dimensional ◽  
Adipose Derived Stem Cells ◽  
Brown Adipose

Human metabolically active brown adipose tissue derived stem cells

Cytotherapy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. S69
Author(s):  
F. Silva ◽  
D. Holt ◽  
V. Vargas ◽  
D. Bull ◽  
A.N. Patel
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose

Tbx18-dependent differentiation of brown adipose tissue-derived stem cells toward cardiac pacemaker cells

2017 ◽  
Vol 433 (1-2) ◽  
pp. 61-77 ◽  
Author(s):  
Lei Chen ◽  
Zi-Jun Deng ◽  
Jian-Sheng Zhou ◽  
Rui-Juan Ji ◽  
Xi Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cardiac Pacemaker ◽  
Pacemaker Cells ◽  
Brown Adipose

Functional characterization of human brown adipose tissue metabolism

2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Functional Characterization ◽  
Human Infants ◽  
Positron Emission ◽  
Brown Adipose ◽  
Treatment Of Obesity ◽  
And Function

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

Brown adipose tissue (BAT) can normalize hyperglycemia and hypertriglyceridemia in mice

2011 ◽  
Vol 6 (S 01) ◽  
Author(s):  
M Merkel ◽  
A Bartelt ◽  
K Brügelmann ◽  
J Heeren
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose
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