The Effect of Brown Adipose Tissue Orginated Stem Cells on Wound Healing in Diabetic Rat Model

2017 ◽  
Author(s):  
Busra Sen
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Rat Model ◽  
Diabetic Rat ◽  
Brown Adipose ◽  
Diabetic Rat Model

scholarly journals Adipose Tissue-Derived Stem Cells Ameliorate Diabetic Bladder Dysfunction in a Type II Diabetic Rat Model

2012 ◽  
Vol 21 (9) ◽  
pp. 1391-1400 ◽  
Author(s):  
Haiyang Zhang ◽  
Xuefeng Qiu ◽  
Alan W. Shindel ◽  
Hongxiu Ning ◽  
Ludovic Ferretti ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Rat Model ◽  
Bladder Dysfunction ◽  
Diabetic Rat ◽  
Type Ii ◽  
Diabetic Bladder ◽  
Diabetic Rat Model

scholarly journals Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Enrique Calvo ◽  
Noelia Keiran ◽  
Catalina Núñez-Roa ◽  
Elsa Maymó-Masip ◽  
Miriam Ejarque ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Therapeutic Option ◽  
Metabolic Activation ◽  
Diet Induced Obesity ◽  
Brown Adipose ◽  
Obesity In Mice ◽  
Treatment Of Obesity ◽  
Visceral Adipose

AbstractAdipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. Despite the recent identification of brown adipose tissue (BAT) as a potential target in the management of obesity, the use of ASCs isolated from BAT as a therapy for patients with obesity has not yet been explored. Metabolic activation of BAT has been shown to have not only thermogenic effects, but it also triggers the secretion of factors that confer protection against obesity. Herein, we isolated and characterized ASCs from the visceral adipose tissue surrounding a pheochromocytoma (IB-hASCs), a model of inducible BAT in humans. We then compared the anti-obesity properties of IB-hASCs and human ASCs isolated from visceral white adipose tissue (W-hASCs) in a murine model of diet-induced obesity. We found that both ASC therapies mitigated the metabolic abnormalities of obesity to a similar extent, including reducing weight gain and improving glucose tolerance. However, infusion of IB-hASCs was superior to W-hASCs in suppressing lipogenic and inflammatory markers, as well as preserving insulin secretion. Our findings provide evidence for the metabolic benefits of visceral ASC infusion and support further studies on IB-hASCs as a therapeutic option for obesity-related comorbidities.

Brown adipose tissue activation in a rat model of Parkinson’s disease

2017 ◽  
Vol 313 (6) ◽  
pp. E731-E736 ◽  
Author(s):  
Wenjuan Wang ◽  
Xiangzhi Meng ◽  
Chun Yang ◽  
Dongliang Fang ◽  
Xuemeng Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Weight Loss ◽  
Body Weight ◽  
Adipose Tissue ◽  
Energy Expenditure ◽  
Brown Adipose Tissue ◽  
Energy Intake ◽  
Rat Model ◽  
Sympathetic Denervation ◽  
Brown Adipose

Loss of body weight and fat mass is one of the nonmotor symptoms of Parkinson’s disease (PD). Weight loss is due primarily to reduced energy intake and increased energy expenditure. Whereas inadequate energy intake in PD patients is caused mainly by appetite loss and impaired gastrointestinal absorption, the underlying mechanisms for increased energy expenditure remain largely unknown. Brown adipose tissue (BAT), a key thermogenic tissue in humans and other mammals, plays an important role in thermoregulation and energy metabolism; however, it has not been tested whether BAT is involved in the negative energy balance in PD. Here, using the 6-hydroxydopamine (6-OHDA) rat model of PD, we found that the activity of sympathetic nerve (SN), the expression of Ucp1 in BAT, and thermogenesis were increased in PD rats. BAT sympathetic denervation blocked sympathetic activity and decreased UCP1 expression in BAT and attenuated the loss of body weight in PD rats. Interestingly, sympathetic denervation of BAT was associated with decreased sympathetic tone and lipolysis in retroperitoneal and epididymal white adipose tissue. Our data suggeste that BAT-mediated thermogenesis may contribute to weight loss in PD.

Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds

2020 ◽  
pp. 088532822096389
Author(s):  
Gamze Kara Magden ◽  
Cigdem Vural ◽  
Busra Yaprak Bayrak ◽  
Candan Yilmaz Ozdogan ◽  
Halime Kenar
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Rat Model ◽  
Small Intestinal Submucosa ◽  
Diabetic Rat ◽  
Control Group ◽  
Significant Difference ◽  
Small Intestinal ◽  
Intestinal Submucosa ◽  
Diabetic Rat Model

Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses. Diabetes comes first among the reasons of non traumatic foot amputations. To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand. In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model. The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture. Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS). The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test. All sponges had a similar Young’s modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa). Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05). On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05). Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.

Pterocarpus marsupium Roxburgh heartwood extract/chitosan nanoparticles loaded hydrogel as an innovative wound healing agent in the diabetic rat model

2021 ◽  
Vol 26 ◽  
pp. 101916
Author(s):  
Anupama Ammulu Manne ◽  
Bharathi Arigela ◽  
Ajay Kumar Giduturi ◽  
Ravi K. Komaravolu ◽  
Ushakiranmayi Mangamuri ◽  
...  
Keyword(s):  
Wound Healing ◽  
Rat Model ◽  
Chitosan Nanoparticles ◽  
Diabetic Rat ◽  
Pterocarpus Marsupium ◽  
Healing Agent ◽  
Diabetic Rat Model

scholarly journals A new waterborne chitosan-based polyurethane hydrogel as a vehicle to transplant bone marrow mesenchymal cells improved wound healing of ulcers in a diabetic rat model

2020 ◽  
Vol 231 ◽  
pp. 115734 ◽  
Author(s):  
Christian Viezzer ◽  
Rafael Mazzuca ◽  
Denise Cantarelli Machado ◽  
Maria Madalena de Camargo Forte ◽  
José Luis Gómez Ribelles
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Rat Model ◽  
Mesenchymal Cells ◽  
Diabetic Rat ◽  
Polyurethane Hydrogel ◽  
Bone Marrow Mesenchymal Cells ◽  
Diabetic Rat Model

Cardiac Stem Cells in Brown Adipose Tissue Express CD133 and Induce Bone Marrow Nonhematopoietic Cells to Differentiate into Cardiomyocytes

Stem Cells ◽  
2007 ◽  
Vol 25 (5) ◽  
pp. 1326-1333 ◽  
Author(s):  
Yoshihiro Yamada ◽  
Shin-ichiro Yokoyama ◽  
Xiang-Di Wang ◽  
Noboru Fukuda ◽  
Nobuyuki Takakura
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cardiac Stem Cells ◽  
Brown Adipose

scholarly journals Weight loss and brown adipose tissue reduction in rat model of sleep apnea

2008 ◽  
Vol 7 (1) ◽  
pp. 26 ◽  
Author(s):  
Denis Martinez ◽  
Luiz FT Vasconcellos ◽  
Patricia G de Oliveira ◽  
Signorá P Konrad
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Sleep Apnea ◽  
Brown Adipose Tissue ◽  
Rat Model ◽  
Brown Adipose ◽  
Tissue Reduction
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