scholarly journals Effect of Physicochemical Properties in Water on Release Profile of Metominostrobin from Time-Controlled Release Granule

2001 ◽  
Vol 26 (3) ◽  
pp. 244-247 ◽  
Author(s):  
Shigeru TASHIMA ◽  
Shinji SHIMADA ◽  
Kohei MATSUMOTO ◽  
Reiji TAKEDA ◽  
Tomonori SHIRAISHI
Keyword(s):  
Controlled Release ◽  
Physicochemical Properties ◽  
Release Profile

Optimization Study to Develop Once-a-day Controlled Release Formulation of Metoclopramide with Predictable Design Space

1970 ◽  
Vol 1 (1) ◽  
pp. 71-76
Author(s):  
Rajesh Dubey ◽  
Udaya K. Chowdary ◽  
Venkateswarlu V.
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Design Space ◽  
Release Kinetics ◽  
Release Profile ◽  
Release Formulation ◽  
Linear Effect ◽  
Controlled Release Formulation ◽  
The Difference ◽  
Face Centered

A controlled release formulation of metoclopramide was developed using a combination of hypromellose (HPMC) and hydrogenated castor oil (HCO). Developed formulations released the drug over 20 hr with release kinetics following Higuchi model. Compared to HCO, HPMC showed significantly higher influence in controlling the drug release at initial as well as later phase. The difference in the influence can be explained by the different swelling and erosion behaviour of the polymers. Effect of the polymers on release was optimized using a face-centered central composite design to generate a predictable design space. Statistical analysis of the drug release at various levels indicated a linear effect of the polymers’ levels on the drug release. The release profile of formulations containing the polymer levels at extremes of their ranges in design space was found to be similar to the predicted release profile

Structural comparison, physicochemical properties, and in vitro release profile of curcumin-loaded lyotropic liquid crystalline nanoparticle: Influence of hydrotrope as interface stabilizers

2020 ◽  
Vol 306 ◽  
pp. 112861 ◽  
Author(s):  
Juliana Ferreira de Souza ◽  
Katiusca da Silva Pontes ◽  
Thais Francine Ribeiro Alves ◽  
Cecilia Torqueti de Barros ◽  
Venancio Alves Amaral ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Liquid Crystalline ◽  
In Vitro Release ◽  
Release Profile ◽  
Structural Comparison ◽  
Vitro Release

The release profile of a controlled release preparation of 5-aminosalicylic acid (Rowasa I®) in humans

1990 ◽  
Vol 33 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Robin S. McLeod ◽  
Zane Cohen ◽  
Barbara J. Vari ◽  
Joan E. Blair ◽  
Gordon R. Greenberg
Keyword(s):  
Controlled Release ◽  
Release Profile ◽  
Aminosalicylic Acid ◽  
Release Preparation

Effect of additives on release profile of leuprolide acetate in anin situ forming controlled-release system:In vitro study

2007 ◽  
Vol 107 (6) ◽  
pp. 3781-3787 ◽  
Author(s):  
M. Zare ◽  
H. Mobedi ◽  
J. Barzin ◽  
H. Mivehchi ◽  
A. Jamshidi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Release Profile ◽  
Leuprolide Acetate ◽  
Vitro Study ◽  
Effect Of Additives
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