Effect of additives on release profile of leuprolide acetate in anin situ forming controlled-release system:In vitro study

2007 ◽  
Vol 107 (6) ◽  
pp. 3781-3787 ◽  
Author(s):  
M. Zare ◽  
H. Mobedi ◽  
J. Barzin ◽  
H. Mivehchi ◽  
A. Jamshidi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Release Profile ◽  
Leuprolide Acetate ◽  
Vitro Study ◽  
Effect Of Additives

Optimization Study to Develop Once-a-day Controlled Release Formulation of Metoclopramide with Predictable Design Space

1970 ◽  
Vol 1 (1) ◽  
pp. 71-76
Author(s):  
Rajesh Dubey ◽  
Udaya K. Chowdary ◽  
Venkateswarlu V.
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Design Space ◽  
Release Kinetics ◽  
Release Profile ◽  
Release Formulation ◽  
Linear Effect ◽  
Controlled Release Formulation ◽  
The Difference ◽  
Face Centered

A controlled release formulation of metoclopramide was developed using a combination of hypromellose (HPMC) and hydrogenated castor oil (HCO). Developed formulations released the drug over 20 hr with release kinetics following Higuchi model. Compared to HCO, HPMC showed significantly higher influence in controlling the drug release at initial as well as later phase. The difference in the influence can be explained by the different swelling and erosion behaviour of the polymers. Effect of the polymers on release was optimized using a face-centered central composite design to generate a predictable design space. Statistical analysis of the drug release at various levels indicated a linear effect of the polymers’ levels on the drug release. The release profile of formulations containing the polymer levels at extremes of their ranges in design space was found to be similar to the predicted release profile

scholarly journals Effect of Physicochemical Properties in Water on Release Profile of Metominostrobin from Time-Controlled Release Granule

2001 ◽  
Vol 26 (3) ◽  
pp. 244-247 ◽  
Author(s):  
Shigeru TASHIMA ◽  
Shinji SHIMADA ◽  
Kohei MATSUMOTO ◽  
Reiji TAKEDA ◽  
Tomonori SHIRAISHI
Keyword(s):  
Controlled Release ◽  
Physicochemical Properties ◽  
Release Profile

The release profile of a controlled release preparation of 5-aminosalicylic acid (Rowasa I®) in humans

1990 ◽  
Vol 33 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Robin S. McLeod ◽  
Zane Cohen ◽  
Barbara J. Vari ◽  
Joan E. Blair ◽  
Gordon R. Greenberg
Keyword(s):  
Controlled Release ◽  
Release Profile ◽  
Aminosalicylic Acid ◽  
Release Preparation

Drug release profile and reduction in the in vitro burst release from pectin/HEMA hydrogel nanocomposites crosslinked with titania

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 19060-19068 ◽  
Author(s):  
Elisangela P. da Silva ◽  
Marcos R. Guilherme ◽  
Francielle P. Garcia ◽  
Celso V. Nakamura ◽  
Lucio Cardozo-Filho ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Release Profile ◽  
Burst Release ◽  
Drug Release Profile ◽  
Initial Release ◽  
Hydrogel Nanocomposites

Hydrogel nanocomposites of pectin, HEMA and titania for Vit-B12 controlled release with reduced initial release burst were prepared. A reduction of up to ca. 60% was observed.

A Novel Biodegradable Multichamber Microstructure for Implantable Drug Controlled Release

2010 ◽  
Vol 654-656 ◽  
pp. 2269-2272
Author(s):  
Rui Xia Yu ◽  
Xiang Yang Zhou ◽  
Zeng Zhao
Keyword(s):  
Topology Optimization ◽  
Controlled Release ◽  
Drug Release ◽  
Research Work ◽  
Release Profile ◽  
Drug Release Profile ◽  
Drug Controlled Release ◽  
Simulation Results ◽  
Micro Molding

The research work reported in this paper design a novel biodegradable multichamber microstructure for implantable drug controlled release by introducing the approach of topology optimization. It is therefore highly desirable to overcome these restrictions that pre-defined topology of the device result in difficulty to obtain a linear or pulsed drug release profile. The designed biodegradable multichamber microstructure is fabricated using UV-LIGA microfabrication and Micro-molding technique. The simulation results show that the multichamber microstructure exhibits a preferable linear drug release profile.

Formulation Development of Metoprolol Succinate Controlled Release Tablets using Ethyl-cellulose-polyvinyl-pyrrolidone Coating

2015 ◽  
Vol 8 (2) ◽  
pp. 2851-2857
Author(s):  
Kiran Kumar Vangara ◽  
Kishore K. Konda ◽  
Shiva K. Ravula ◽  
Pradeep K Vuppala ◽  
Vijay K. Sripuram ◽  
...  
Keyword(s):  
Weight Gain ◽  
Controlled Release ◽  
Drug Release ◽  
Ethyl Cellulose ◽  
Film Coating ◽  
Release Profile ◽  
Water Soluble ◽  
Metoprolol Succinate ◽  
Water Soluble Drug

It is challenging to develop a controlled release (CR) formulation for a freely water soluble drug molecule without using rate controlling polymers in the core matrix. This study is aimed to develop and evaluate cost-effective ethyl cellulose (EC)-polyvinyl pyrrolidone (PVP) film coating that can effectively control the release of freely water soluble drug, metoprolol succinate (MS) and to match that of release profile with its marketed tablet. Simple core tables of MS were compressed and coated with a solution composed of hydrophobic rate controlling polymer, EC and water soluble pore forming polymer, PVP. The effect of formulation parameters such as the ratio of EC to PVP and tablet coating weight gain on the in-vitro drug release were evaluated. Release profile of the optimized formulation at different pH conditions was determined and the similarity factor (f2) with marketed release profile was calculated.It was observed that drug release rate increased with a decrease in the ratio of ethyl cellulose to PVP and decreased with increased weight gain of the coating membrane. Among all the formulations, the formulation with EC and PVP at a ratio of 60:40 %w/w and 9% weight gain showed matching release profile to marketed tablet with f2 value of 72.25. The optimized formulation showed pH independent in-vitro release. This study successfully demonstrated that EC-PVP film coating can effectively control the release rate of freely soluble drugs. Once a day CR formulation of metoprolol succinate pharmaceutically equivalent to marketed tablet was developed.  

DEVELOPMENT AND CHARACTERIZATION OF ELEMENTARY OSMOTIC PUMP TABLETS FOR SIMULTANEOUS RELEASE OF METFORMIN AND GLIPIZIDE

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (11) ◽  
pp. 19-29
Author(s):  
P Bharadwaj ◽  
◽  
P. K Upaddhyay ◽  
V Agarwal ◽  
D Chaurasia ◽  
...  
Keyword(s):  
Controlled Release ◽  
Release Profile ◽  
Osmotic Pump ◽  
Dependent Diabetes Mellitus ◽  
Wet Granulation ◽  
Type Ii ◽  
Surface Porosity ◽  
Before And After ◽  
Method Effects

The aim of present study was to design and evaluate an elementary osmotic pump-based drug delivery system for controlled release of metformin and glipizide simultaneously for treatment of type II noninsulin dependent diabetes mellitus. Inclusion complex of glipizide with β- cyclodextrin was prepared to enhance its solubility. Core tablets were prepared by wet granulation method. Effects of different variables like amount of plasticizer, osmogen, orifice size and dissolution media were studied on release profile for both drugs. Morphology of semi permeable was studied using electron microscope before and after dissolution test. On increasing the amount of osmogen, the release of both drugs was found to be increased. No significant effect of PVP K 30 was observed on drug release. Optimization results indicated that the release of both drugs was directly proportional to the surface porosity of the membrane. It was concluded that the osmotic pump tablets could provide more prolonged and controlled release that may result in an improved therapeutic efficacy and patient compliance.

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