scholarly journals Effect of α-rat Atrial Natriuretic Polypeptide on Blood Pressure in Rats Bilateral Renal Vessels Ligated

1985 ◽  
Vol 26 (4) ◽  
pp. 699-699 ◽  
Author(s):  
Yoshiro Sogawa ◽  
Masahiro Kihara ◽  
Masayuki Mano ◽  
Kazuwa Nakao ◽  
Akira Sugawara ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Atrial Natriuretic Polypeptide ◽  
Renal Vessels ◽  
Atrial Natriuretic

Effect of intracerebroventricular atrial natriuretic polypeptide on blood pressure and urine production in rats

Life Sciences ◽  
1986 ◽  
Vol 39 (14) ◽  
pp. 1263-1270 ◽  
Author(s):  
Toshikatsu Shimizu ◽  
Goro Katsuura ◽  
Masuhisa Nakamura ◽  
Kazuwa Nakao ◽  
Narito Morii ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Atrial Natriuretic Polypeptide ◽  
Urine Production ◽  
Atrial Natriuretic

Relationship between the renin–aldosterone system and atrial natriuretic polypeptide in rats

1987 ◽  
Vol 72 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Yasunobu Hirata ◽  
Masao Ishii ◽  
Tokuichiro Sugimoto ◽  
Matsuoka Hiroaki ◽  
Toshihiko Ishimitsu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Blood Pressure Reduction ◽  
Plasma Concentrations ◽  
Inhibitory Effect ◽  
Atrial Natriuretic Polypeptide ◽  
Body Fluid Volume ◽  
The Relationship ◽  
Atrial Natriuretic

1. In order to examine the relationship between the renin–aldosterone system and atrial natriuretic polypeptide (ANP), we investigated the effects of α-human atrial natriuretic polypeptide (α-hANP) on the plasma concentrations of renin (PRC) and aldosterone (PAC), as well as the effects of captopril pretreatment on the natriuresis and blood pressure reduction induced by α-hANP in rats. 2. Although α-hANP infused into conscious rats at 0.67 μg min−1 kg−1 markedly increased the urinary excretion of sodium and decreased mean arterial pressure, its infusion did not change PRC; however, it significantly lowered PAC. Frusemide infusion at 20.8 μg min−1 kg−1 induced natriuresis comparable with that of α-hANP and it elevated both PRC and PAC, but mean arterial pressure was not altered. 3. Pretreatment of rats with captopril did not have any significant influence on the acute natriuretic and hypotensive effects of α-hANP. 4. Although the inhibitory effect of ANP on the renin-aldosterone system may be involved in the chronic modulation of body fluid volume and blood pressure, this effect does not seem to be directly involved in the acute natriuretic and hypotensive effects of the peptide.

Human atrial natriuretic polypeptide during escape from mineralocorticoid excess in man

1987 ◽  
Vol 73 (4) ◽  
pp. 431-436 ◽  
Author(s):  
Isamu Miyamori ◽  
Masatoshi Ikeda ◽  
Takao Matsubara ◽  
Shinya Okamoto ◽  
Hideo Koshida ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Creatinine Clearance ◽  
Plasma Concentrations ◽  
Sodium Balance ◽  
Abrupt Increase ◽  
The Third ◽  
Atrial Natriuretic Polypeptide ◽  
The Mean ◽  
Fludrocortisone Acetate ◽  
Atrial Natriuretic

1. Plasma concentrations of human α-atrial natriuretic polypeptide (h-αANP) during escape from the effects of mineralocorticoid excess were determined in six healthy volunteers. 2. Escape, as indicated by an abrupt increase in sodium excretion on the third to sixth day of 9α-fludrocortisone acetate administration (0.6 mg/day), was observed in all subjects. 3. The mean plasma h-αANP level was 30.9 ± sem 8.8 pmol/l on the control day; it increased exponentially in response to 9α-fludrocortisone acetate administration, reached a significant level (114.0 ± 22.4 pmol/l, P < 0.05) on the day before escape and remained elevated during escape. 4. The 24 h creatinine clearance and blood pressure did not change significantly before the escape. Plasma h-αANP increased markedly when the cumulative sodium balance exceeded 220 mmol. 5. These results suggest that h-αANP may play a contributory role in natriuresis and diuresis after mineralocorticoid excess.

scholarly journals Effects of .ALPHA.-human atrial natriuretic polypeptide (.ALPHA.-hANP) on the main regulatory mechanisms for blood pressure and body fluid volume in rats.

1985 ◽  
Vol 49 (9) ◽  
pp. 969-972 ◽  
Author(s):  
MASAO ISHII ◽  
HIROAKI MATSUOKA ◽  
YASUNOBU HIRATA ◽  
TOKUICHIRO SUGIMOTO ◽  
TOSHIHIKO ISHIMITSU ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Fluid ◽  
Fluid Volume ◽  
Regulatory Mechanisms ◽  
Atrial Natriuretic Polypeptide ◽  
Body Fluid Volume ◽  
Atrial Natriuretic

scholarly journals Blood pressure, renal and endocrine responses to .ALPHA.-human atrial natriuretic polypeptide in healthy volunteers.

1986 ◽  
Vol 27 (6) ◽  
pp. 777-789 ◽  
Author(s):  
Masao ISHII ◽  
Tokuichiro SUGIMOTO ◽  
Hiroaki MATSUOKA ◽  
Toshihiko ISHIMITSU ◽  
Keiichiro ATARASHI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Healthy Volunteers ◽  
Atrial Natriuretic Polypeptide ◽  
Atrial Natriuretic

Atrial natriuretic polypeptide during exercise in healthy man

1987 ◽  
Vol 116 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Yoshihiko Saito ◽  
Kazuwa Nakao ◽  
Akira Sugawara ◽  
Kazunobu Nishimura ◽  
Makoto Sakamoto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Plasma Concentration ◽  
Oxygen Uptake ◽  
Systolic Blood Pressure ◽  
Exercise Test ◽  
Maximal Oxygen Uptake ◽  
Plasma Norepinephrine ◽  
Atrial Natriuretic Polypeptide ◽  
Atrial Natriuretic

Abstract. The plasma concentration of atrial natriuretic polypeptide was measured in eight healthy men during two grades of exercise performed in the supine position on a bicycle ergometer. The plasma concentration of atrial natriuretic polypeptide slightly increased during the first exercise test with 20% of the maximal oxygen uptake and it approximately doubled during the second exercise with 40% of the maximal oxygen uptake (from 15.5 ± 5.5 (mean ± sd) pmol/l to 31.8 ± 10.7 pmol/l). The increase in the plasma level of atrial natriuretic polypeptide in the second exercise was significantly greater than that in the first one. The plasma norepinephrine level and plasma renin activity showed significant increases during the second exercise test. Heart rate and systolic blood pressure also increased in response to the graded exercise. The increase in the plasma concentration of atrial natriuretic polypeptide during exercise was significantly correlated with the increase in heart rate, systolic blood pressure, and the plasma norepinephrine concentration (r = 0.75, r = 0.71 and r = 0.51, respectively). These results indicate that the plasma concentration of atrial natriuretic polypeptide increases in response to the intensity of a workload, and suggest that exercise is a useful test to evaluate the releasing function of atrial natriuretic polypeptide in the heart.

Central action of atrial natriuretic polypeptide on blood pressure in conscious rats

1986 ◽  
Vol 16 (5) ◽  
pp. 745-749 ◽  
Author(s):  
Hiroshi Itoh ◽  
Kazuwa Nakao ◽  
Narito Morii ◽  
Takayuki Yamada ◽  
Shozo Shiono ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Central Action ◽  
Conscious Rats ◽  
Atrial Natriuretic Polypeptide ◽  
Atrial Natriuretic
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