scholarly journals Effects of .ALPHA.-human atrial natriuretic polypeptide (.ALPHA.-hANP) on the main regulatory mechanisms for blood pressure and body fluid volume in rats.

1985 ◽  
Vol 49 (9) ◽  
pp. 969-972 ◽  
Author(s):  
MASAO ISHII ◽  
HIROAKI MATSUOKA ◽  
YASUNOBU HIRATA ◽  
TOKUICHIRO SUGIMOTO ◽  
TOSHIHIKO ISHIMITSU ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Fluid ◽  
Fluid Volume ◽  
Regulatory Mechanisms ◽  
Atrial Natriuretic Polypeptide ◽  
Body Fluid Volume ◽  
Atrial Natriuretic

scholarly journals A Possible Physiological Role of Atrial Natriuretic Peptide in Body Fluid Volume Regulation

1988 ◽  
Vol 13 ◽  
pp. S62-S68
Author(s):  
Yasunobu Hirata ◽  
Masao Ishii ◽  
Kazushige Fukui ◽  
Hiroshi Hayakawa ◽  
Shin-ichiro Namba ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Volume Regulation ◽  
Body Fluid ◽  
Physiological Role ◽  
Fluid Volume ◽  
Body Fluid Volume ◽  
Fluid Volume Regulation ◽  
Atrial Natriuretic

Relationship between the renin–aldosterone system and atrial natriuretic polypeptide in rats

1987 ◽  
Vol 72 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Yasunobu Hirata ◽  
Masao Ishii ◽  
Tokuichiro Sugimoto ◽  
Matsuoka Hiroaki ◽  
Toshihiko Ishimitsu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Blood Pressure Reduction ◽  
Plasma Concentrations ◽  
Inhibitory Effect ◽  
Atrial Natriuretic Polypeptide ◽  
Body Fluid Volume ◽  
The Relationship ◽  
Atrial Natriuretic

1. In order to examine the relationship between the renin–aldosterone system and atrial natriuretic polypeptide (ANP), we investigated the effects of α-human atrial natriuretic polypeptide (α-hANP) on the plasma concentrations of renin (PRC) and aldosterone (PAC), as well as the effects of captopril pretreatment on the natriuresis and blood pressure reduction induced by α-hANP in rats. 2. Although α-hANP infused into conscious rats at 0.67 μg min−1 kg−1 markedly increased the urinary excretion of sodium and decreased mean arterial pressure, its infusion did not change PRC; however, it significantly lowered PAC. Frusemide infusion at 20.8 μg min−1 kg−1 induced natriuresis comparable with that of α-hANP and it elevated both PRC and PAC, but mean arterial pressure was not altered. 3. Pretreatment of rats with captopril did not have any significant influence on the acute natriuretic and hypotensive effects of α-hANP. 4. Although the inhibitory effect of ANP on the renin-aldosterone system may be involved in the chronic modulation of body fluid volume and blood pressure, this effect does not seem to be directly involved in the acute natriuretic and hypotensive effects of the peptide.

Regulation of Body Fluid Volume: The Atrial Natriuretic Factor

Physiology ◽  
1986 ◽  
Vol 1 (1) ◽  
pp. 3-5
Author(s):  
J Genest ◽  
C Marc
Keyword(s):  
Atrial Natriuretic Factor ◽  
Body Fluid ◽  
Analytical Techniques ◽  
Fluid Volume ◽  
Isolation And Characterization ◽  
Natriuretic Factor ◽  
Body Fluid Volume ◽  
Made In ◽  
Atrial Natriuretic

The discovery of the atrial natriuretic factor is a major breakthrough for our understanding of the regulation of body fluid volume. It plays a major role in vasorelaxation and in hypertensive and edematous states. The progress made in the last two years is a testimony to the powers of the new analytical techniques for isolation and characterization of peptides.

scholarly journals A Possible Physiological Role of Atrial Natriuretic Peptide in Body Fluid Volume Regulation

1989 ◽  
Vol 13 ◽  
pp. S62-S68 ◽  
Author(s):  
Yasunobu Hirata ◽  
Masao Ishii ◽  
Kazushige Fukui ◽  
Hiroshi Hayakawa ◽  
Shin-ichiro Namba ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Volume Regulation ◽  
Body Fluid ◽  
Physiological Role ◽  
Fluid Volume ◽  
Body Fluid Volume ◽  
Fluid Volume Regulation ◽  
Atrial Natriuretic

Sodium and angiotensin in the pathogenesis of experimental renovascular hypertension

1981 ◽  
Vol 240 (5) ◽  
pp. H788-H792
Author(s):  
A. A. Seymour ◽  
J. O. Davis ◽  
R. H. Freeman ◽  
J. M. DeForrest ◽  
B. P. Rowe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Renovascular Hypertension ◽  
Body Fluid ◽  
Renin Angiotensin System ◽  
Fluid Volume ◽  
Sodium Restriction ◽  
Sodium Depletion ◽  
Body Fluid Volume ◽  
Angiotensin Blockade

The effects of simultaneous angiotensin blockade and sodium depletion on the development of one-kidney renovascular hypertension were studied in rats. In sodium-replete rats, systolic blood pressure (SBP) increased from 102 +/- 2 to 153 +/- 11 mmHg by the 12th day after unilateral nephrectomy and subsequent partial occlusion of the renal artery with a 0.22-mm silver clip. When changes in body fluid volume were minimized by sodium restriction in a second group of rats, the increase in SBP from 98 +/- 4 to 149 +/- 7 mmHg after clipping was not different from that in sodium-replete animals. Inhibition of the angiotensin-converting enzyme with SQ 14,225 during sodium restriction prevented the SBP from increasing above 101 +/- 3 mmHg by the 12th day after nephrectomy and clipping. Once SQ 14,225 administration was discontinued, SBP rose significantly to 148 +/- 5 mmHg within 5 days. Because previous studies have shown that neither sodium depletion nor angiotensin blockade alone prevented the development of one-kidney renovascular hypertension, it is concluded that the increase in blood pressure resulting from renal artery constriction and contralateral nephrectomy was prevented only by suppression of both the renin-angiotensin system and body fluid volume.

The involvement of vasopressin in the renal actions of atrial natriuretic peptide in conscious fluid-balanced rats

1993 ◽  
Vol 138 (3) ◽  
pp. 413-420 ◽  
Author(s):  
W. J. Burgess ◽  
R. J. Balment
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Body Fluid ◽  
Plasma Concentrations ◽  
Fluid Volume ◽  
Conscious Rats ◽  
Physiological Range ◽  
Arterial Blood ◽  
Body Fluid Volume ◽  
Atrial Natriuretic

ABSTRACT The renal and endocrine actions of atrial natriuretic peptide (ANP) administered at a rate to induce plasma concentrations within the physiological range have been re-examined in conscious rats in which body fluid volume was maintained by infusion of replacement fluid at a rate to match spontaneous urine losses (servo-controlled replacement) throughout experimentation. The involvement of vasopressin in the actions of ANP was assessed by comparing the responses induced in Brattleboro (DI) and Long–Evans (LE) rats. A rate of ANP administration inducing a less than twofold increment in circulating ANP concentration evoked a small but significant diuresis and natriuresis. In contrast to previous studies during which body fluid balance had not been maintained and the response to ANP was transient, renal responses were rapid in onset and sustained over the period of hormone administration. The change in renal excretion occurred without concomitant changes in mean arterial blood pressure, haematocrit or glomerular filtration rate, and without consistent alterations in the circulating concentrations of angiotensin II, vasopressin, aldosterone or corticosterone. Furthermore, although small differences between the two strains in the character of the response could be demonstrated, the evoked response was of similar magnitude in vasopressin-replete and -deficient animals. In summary, in conscious rats in which body fluid volume was maintained, the profile of the diuretic and natriuretic responses evoked by low-rate ANP administration was different from that previously observed in anaesthetized and/or constantly infused preparations; being rapid in onset and sustained. The similarity in the renal effects observed following ANP administration in LE and DI rats in the present study suggests that vasopressin is not a prerequisite for the renal actions of ANP evoked by plasma concentrations within the physiological range. Journal of Endocrinology (1993) 138, 413–420

scholarly journals Dehydration increases the density of C receptors for ANF on rat glomerular membranes

1990 ◽  
Vol 258 (4) ◽  
pp. R1084-R1088 ◽  
Author(s):  
M. C. Kollenda ◽  
A. M. Vollmar ◽  
G. A. McEnroe ◽  
A. L. Gerbes
Keyword(s):  
Binding Sites ◽  
Atrial Natriuretic Factor ◽  
Body Fluid ◽  
Fluid Volume ◽  
Control Group ◽  
Receptor Density ◽  
Lower Plasma ◽  
Short Term ◽  
Salt Loading ◽  
Body Fluid Volume

The present study determined the presence of two types of binding sites for atrial natriuretic factor (ANF), the B and C receptor, on rat glomerular membranes. The effect of short-term salt loading and dehydration on these two receptor populations was investigated consecutively. Salt-loaded rats did not show significant changes in plasma ANF concentrations or in the number of ANF binding sites. Water-deprived rats presented significantly lower plasma ANF concentrations (22.0 +/- 1.9 vs. 34.4 +/- 3.8 fmol/ml, P less than 0.01) and an increase in total receptor density (1,860 +/- 398 vs. 987 +/- 143 fmol/mg protein) as compared with the control group. Differentiation of both receptor populations showed that it was the C receptors that accounted for this increase (1,772 +/- 369 vs. 901 +/- 151 fmol/mg protein, P less than 0.05), whereas B-receptor density was unchanged (89 +/- 31 vs. 87 +/- 44 fmol/mg protein). These data suggest that C receptors for ANF are affected by changes of body fluid volume.

scholarly journals On the question of body fluid volume or sodium status influencing renin release.

1977 ◽  
Vol 267 (2) ◽  
pp. 321-338 ◽  
Author(s):  
J R Blair-West ◽  
A H Brook ◽  
P A Simpson
Keyword(s):  
Body Fluid ◽  
Fluid Volume ◽  
Renin Release ◽  
Body Fluid Volume
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