CARBOHYDRATE METABOLISM IN PREGNANCY

1970 ◽  
Vol 65 (2) ◽  
pp. 352-360 ◽  
Author(s):  
Robert H. Knopp ◽  
Henry J. Ruder ◽  
Emilio Herrera ◽  
Norbert Freinkel

ABSTRACT The effects of pregnancy and dietary status upon the blood sugar response to exogenous insulin in the rat were evaluated. Unanaesthetized 19-day pregnant, postpartum, and age-matched virgin rats were challenged with intravenous insulin (10 U/kg) after unrestricted access to food or fasting for 48 hours. Appropriate control studies were instituted to correct for the effects of 'handling' upon blood sugar. Fed as well as fasted pregnant rats displayed diminished absolute hypoglycaemic responses to insulin and attenuated rates of blood sugar fall. The relative resistance of pregnant rats to the blood sugar lowering actions of insulin was documented during group comparisons with virgin rats as well as upon reexamination of the same animals postpartum.

PEDIATRICS ◽  
1967 ◽  
Vol 40 (1) ◽  
pp. 69-77
Author(s):  
Rosita S. Pildes ◽  
Audrey E. Forbes ◽  
Marvin Cornblath

Blood sugar determinations were done during the first 5 days of life on 100 sets of twins. Hypoglycemia was found in the smaller member in 8 of 11 pairs who were discordant by more than 25% with the smaller twin weighing less than 2.0 kg. Hypoglycemia occurred in one other pair of the remaining 89 sets of twins. Blood glucose values were not influenced by the birth order or the sex of the infants. Infants who weighed over 2,500 gm had significantly higher blood sugars than those who weighed below 2,500 gm.


1929 ◽  
Vol 25 (5) ◽  
pp. 577-577
Author(s):  
Z. Blumstein

Otto Jul Nielsen (Acta medica Scandinavica, Vol. LXX (1929), fase. 1) investigated the effect of septacrol'u (acridine derivative) on blood sugar in various patients with normal carbohydrate metabolism and in diabetics. Septacrol was administered intravenously at 5 kbp. with. In the first cases, the amount of sugar in the blood did not change, and secondly, it is true, there was some decrease, but in magnitude it did not exceed those figures that were obtained in the study of blood sugar in starving patients. These results give N'y the right to consider the action of septacrol to be sharply different from the action of insulin


1925 ◽  
Vol 71 (294) ◽  
pp. 443-473 ◽  
Author(s):  
S. A. Mann

It is a common experience in the investigation of mental disorders that glycosuria is frequently found, thus indicating a tendency in such cases to a faulty carbohydrate metabolism. With the exception of epilepsy, this occurrence of glycosuria has been noted in most mental conditions. Intermittent glycosuria is met with in general paralysis (Kraepelin) (1); Bond (2) and Strauss (3) note it in about 10 per cent. of their cases. In dementia prócox Schultze and Knauer (4) did not observe glycosuria in the apathetic form of hebephrenia, but often found it to occur with catatonic excitement. With other observers (see Allers (5)) they record the marked association of glycosuria with depressed states, while its occurrence in mania was infrequent except in markedly excited and resistive cases.


1934 ◽  
Vol 30 (7-8) ◽  
pp. 784-784
Author(s):  
G. Krause ◽  
H. Marx

The accidental observation of a severely diabetic with furunculosis and high fever, where after giving pyramidon, in addition to a drop in t, a drop in blood sugar was observed for several days, served G. Krause and H. Marx the reason for a more detailed study of the action of Pyramidon, on healthy and diabetic persons.


1948 ◽  
Vol 155 (1) ◽  
pp. 10-14
Author(s):  
Edward J. Van Liere ◽  
J. Clifford Stickney ◽  
David W. Northup

1957 ◽  
Vol 190 (2) ◽  
pp. 239-242
Author(s):  
B. N. Spirtos ◽  
R. G. Stuelke ◽  
N. S. Halmi

Rats fed 10 gm of a commercial diet for 4–5 weeks and fasted for 24 hours showed less rise in liver glycogen and blood sugar levels in response to the injection of epinephrine than did ad libitum-fed-fasted rats. Gastrocnemius glycogen levels were found to be higher in underfed-fasted animals and fell to the same extent as in ad libitum fed-fasted animals when epinephrine was given. Blood lactate concentrations, however, rose less markedly in the underfed-fasted group. This may have been at least partly responsible for the diminished rise in hepatic glycogen and blood sugar.


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