Cartilage and Bone Ingrowth into Porous Titanium Implants

2009 ◽  
pp. 255-255-10
Author(s):  
DD Nelson ◽  
HE Rubash ◽  
DC Mears
Keyword(s):  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants

Novel Micro-CT Based 3-Dimentional Structural Analyses of Porous Biomaterials

2007 ◽  
Vol 330-332 ◽  
pp. 967-970 ◽  
Author(s):  
B. Otsuki ◽  
Mitsuru Takemoto ◽  
Shunsuke Fujibayashi ◽  
Masashi Neo ◽  
Tadashi Kokubo ◽  
...  
Keyword(s):  
Network Structure ◽  
Bone Ingrowth ◽  
Average Pore Size ◽  
Three Dimensional ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Average Pore ◽  
Tissue Ingrowth ◽  
Porous Biomaterials

A porous structure comprises pores and pore throats with a complex three-dimensional network structure, and many investigators have described the relationship between average pore size and the amount of bone ingrowth. However, the influence of network structure or pore throats for tissue ingrowth has rarely been discussed. Bioactive porous titanium implants with 48% porosity were analyzed using specific algorithms for three-dimensional analysis of interconnectivity based on a micro focus X-ray computed tomography system. In vivo histological analysis was performed using the very same implants implanted into the femoral condyles of male rabbits for 6 weeks. This matching study revealed that more poorly differentiated pores tended to have narrow pore throats, especially in their shorter routes to the outside. Data obtained suggest that this sort of novel analysis is useful for evaluating bone and tissue ingrowth into porous biomaterials.

Fabrication of bioactive 3D printed porous titanium implants with Sr ion-incorporated zeolite coatings for bone ingrowth

2018 ◽  
Vol 6 (20) ◽  
pp. 3254-3261 ◽  
Author(s):  
Shuang Wang ◽  
Ruiyan Li ◽  
Dongdong Li ◽  
Zhi-Yong Zhang ◽  
Guancong Liu ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
3D Printed ◽  
Strontium Ion ◽  
Zeolite Coatings

Strontium ion incorporated zeolites are uniformly fabricated on a 3D printed porous titanium scaffold for bone ingrowth.

Bone ingrowth in porous titanium implants produced by 3D fiber deposition

Biomaterials ◽  
2007 ◽  
Vol 28 (18) ◽  
pp. 2810-2820 ◽  
Author(s):  
J LI ◽  
P HABIBOVIC ◽  
M VANDENDOEL ◽  
C WILSON ◽  
J DEWIJN ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Fiber Deposition

scholarly journals Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment

2016 ◽  
Vol 59 ◽  
pp. 690-701 ◽  
Author(s):  
Naoya Taniguchi ◽  
Shunsuke Fujibayashi ◽  
Mitsuru Takemoto ◽  
Kiyoyuki Sasaki ◽  
Bungo Otsuki ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Pore Size ◽  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
In Vivo Experiment

scholarly journals Evaluation of Peri-Implant Bone Grafting Around Surface-Porous Dental Implants: An In Vivo Study in a Goat Model

Materials ◽  
2019 ◽  
Vol 12 (21) ◽  
pp. 3606 ◽  
Author(s):  
Fahad Alshehri ◽  
Mohammed Alshehri ◽  
Terrence Sumague ◽  
Abdurahman Niazy ◽  
John Jansen ◽  
...  
Keyword(s):  
Dental Implants ◽  
Bone Grafting ◽  
Bone Growth ◽  
Bone Ingrowth ◽  
Titanium Implant ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Biomechanical Assessment ◽  
Growth Area

Dental implants with surface-porous designs have been recently developed. Clinically, peri-implant bone grafting is expected to promote early osseointegration and bone ingrowth when applied with surface-porous dental implants in challenging conditions. The aim of this study was to comparatively analyze peri-implant bone healing around solid implants and surface-porous implants with and without peri-implant bone grafting, using biomechanical and histomorphometrical assessment in a goat iliac bone model. A total of 36 implants (4.1 mm wide, 11.5 mm long) divided into three groups, solid titanium implant (STI; n = 12), porous titanium implants (PTI; n = 12) and PTI with peri-implant bone grafting using biphasic calcium phosphate granules (PTI + BCP; n = 12), were placed bilaterally in the iliac crests of six goats. The goats were sacrificed seven weeks post-operatively and then subjected to biomechanical (n = 6 per group) and histomorphometrical (n = 6 per group) assessment. The biomechanical assessment revealed no significant differences between the three types of implants. Although the peri-implant bone-area (PIBA%) measured by histomorphometry (STI: 8.63 ± 3.93%, PTI: 9.89 ± 3.69%, PTI + BCP: 9.28 ± 2.61%) was similar for the three experimental groups, the percentage of new bone growth area (BGA%) inside the porous implant portion was significantly higher (p < 0.05) in the PTI group (10.67 ± 4.61%) compared to the PTI + BCP group (6.50 ± 6.53%). These data demonstrate that peri-implant bone grafting around surface-porous dental implants does not significantly accelerate early osseointegration and bone ingrowth.

The Effect of Hydroxyapatite on Bone Ingrowth into Porous-Coated Titanium Implants

2002 ◽  
Vol 12 (2) ◽  
pp. 153-157 ◽  
Author(s):  
A. Moroni ◽  
C. Faldini ◽  
F. Pegreffi ◽  
S. Giannini
Keyword(s):  
Electron Microscopy ◽  
Bone Formation ◽  
Cancellous Bone ◽  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Press Fit ◽  
Ha Coating ◽  
Backscattered Electron ◽  
Bead Diameter

Two different groups of hydroxyapatite (HA) coated and uncoated porous titanium implants, 250–350 μm and 500–700 μm diameter beads, were press-fit in femoral canine cancellous bone. After 12 weeks, the dogs were euthanized and histomorphometric backscattered electron microscopy studies were carried out. Comparing HA-coated versus uncoated implants in the 250–350 μm bead diameter group percentage of bone (P=0.01) and bone index (P=0.01), were higher in the HA-coated implants. Comparing HA-coated versus uncoated implants in the 500–700 μm bead diameter group bone ingrowth (P=0.01) and bone depth penetration (P=0.008), were higher in HA-coated samples. It can be concluded that the HA coating was an effective method to improve bone formation and ingrowth in the porous implants.

scholarly journals Surface Modification of Porous Titanium Discs Using Femtosecond Laser Structuring

Metals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 748 ◽  
Author(s):  
Ángel Rodríguez ◽  
Paloma Trueba ◽  
José Manuel Amado ◽  
María José Tobar ◽  
Mercè Giner ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Bone Ingrowth ◽  
Hierarchical Structures ◽  
Young Modulus ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Confocal Laser ◽  
In Vitro Test ◽  
Implant Surface

The failure of titanium implants is associated with two main problems that include the bone resorption and fracture of the surrounding bone tissue (stiffness incompatibility) and implant loosening (poor osseointegration). The development of porous titanium implants with low Young modulus solve the stress shielding phenomenon, while the modification of the implant surface must be implemented to promote a fast bond between the implant and bone. In this work, femtosecond laser micromachining was applied to modify the topography of the surface of Ti porous samples obtained by a space-holder technique to obtain hierarchical structures (micro and nano roughness patterns) to enhance osseointegration. Scanning electron microscopy, confocal laser microscopy, and image analysis were used for characterization of the surface morphology, roughness, and porosity before and after performing the laser treatment. Based on these results, the effect of the treatment on the mechanical behavior of the samples was estimated. In addition, a preliminary in-vitro test was performed to verify the adhesion of osteoblasts (filopodia presence) on modified titanium surface. Results revealed that laser texturing generated clusters of micro-holes and micro-columns both on the flat surface of the samples and inside the macro-pores, and periodic nanometric structures across the entire surface. The porous substrate offers suitable biomechanics (stiffness and yield strength) and bio-functional behavior (bone ingrowth and osseointegration), which improves the clinic success of titanium implants.

scholarly journals Complete Osseointegration of a Retrieved 3-D Printed Porous Titanium Cervical Cage

2020 ◽  
Vol 7 ◽  
Author(s):  
Wimar van den Brink ◽  
Nancy Lamerigts
Keyword(s):  
Animal Studies ◽  
Bone Ingrowth ◽  
Fibrous Tissue ◽  
Case Series ◽  
Stress Shielding ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Histological Evaluation ◽  
Anterior Plate ◽  
Bone Apposition

Introduction: Porous 3D-printed titanium has only recently been introduced for spinal applications. Evidence around its use is currently limited to animal studies and only few human case series. This study describes the histological findings of a retrieved EIT cervical cage, explanted 2 years after insertion.Materials and Methods: The patient underwent a double level C4/C5 &amp; C5/C6 anterior cervical decompression using EIT cervical cages without an anterior plate. Two years later the C6/7 level degenerated and began to cause myelopathic symptoms. In order to address the kyphotic imbalance of the cervical spine and fix the C6/7 level, the surgeon decided to remove the C5/6 cervical cage and bridge the fusion from C4 to C7 inclusive. The retrieved cage was histologically evaluated for bone ingrowth and signs of inflammation.Results: MRI demonstrated spinal canal stenosis at C6/C7. Plain radiographs confirmed well-integrated cervical cages at 2 years postoperative. The peroperative surgical need to use a chisel to remove the implant at C5/C6 reconfirmed the solid fusion of the segment. Macroscopically white tissue, indicative of bone, was present at both superior and inferior surfaces of the explanted specimen. Histological evaluation revealed complete osseointegration of the 5 mm high EIT Cellular Titanium® cervical cage, displaying mature lamellar bone in combination with bone marrow throughout the cage. Furthermore, a pattern of trabecular bone apposition (without fibrous tissue interface) and physiological remodeling activity was observed directly on the cellular titanium scaffold.Conclusion: This histological retrieval study of a radiologically fused cervical EIT cage clearly demonstrates complete osseointegration within a 2-year time frame. The scaffold exhibits a bone in growth pattern and maturation of bone tissue similar of what has been demonstrated in animal studies evaluating similar porous titanium implants. The complete osseointegration throughout the cage indicates physiological loading conditions even in the central part of the cage. This pattern suggests the absence, or at least the minimization, of stress-shielding in this type of porous titanium cage.

scholarly journals Understanding long-term silver release from surface modified porous titanium implants

2017 ◽  
Vol 58 ◽  
pp. 550-560 ◽  
Author(s):  
Anish Shivaram ◽  
Susmita Bose ◽  
Amit Bandyopadhyay
Keyword(s):  
Porous Titanium ◽  
Titanium Implants ◽  
Silver Release ◽  
Surface Modified
Sign in / Sign up

Export Citation Format

Share Document