The Effect of Hydroxyapatite on Bone Ingrowth into Porous-Coated Titanium Implants

2002 ◽  
Vol 12 (2) ◽  
pp. 153-157 ◽  
Author(s):  
A. Moroni ◽  
C. Faldini ◽  
F. Pegreffi ◽  
S. Giannini
Keyword(s):  
Electron Microscopy ◽  
Bone Formation ◽  
Cancellous Bone ◽  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Press Fit ◽  
Ha Coating ◽  
Backscattered Electron ◽  
Bead Diameter

Two different groups of hydroxyapatite (HA) coated and uncoated porous titanium implants, 250–350 μm and 500–700 μm diameter beads, were press-fit in femoral canine cancellous bone. After 12 weeks, the dogs were euthanized and histomorphometric backscattered electron microscopy studies were carried out. Comparing HA-coated versus uncoated implants in the 250–350 μm bead diameter group percentage of bone (P=0.01) and bone index (P=0.01), were higher in the HA-coated implants. Comparing HA-coated versus uncoated implants in the 500–700 μm bead diameter group bone ingrowth (P=0.01) and bone depth penetration (P=0.008), were higher in HA-coated samples. It can be concluded that the HA coating was an effective method to improve bone formation and ingrowth in the porous implants.

Characterization of CaP Coating Deposited on Porous Titanium

2008 ◽  
Vol 396-398 ◽  
pp. 307-310 ◽  
Author(s):  
Waléria Silva de Medeiros ◽  
Luiz Carlos Pereira ◽  
Robson Pacheco Pereira ◽  
Marize Varella de Oliveira
Keyword(s):  
Body Fluid ◽  
Calcium Phosphates ◽  
Porous Titanium ◽  
Nucleation And Growth ◽  
Titanium Implants ◽  
Fluid Solution ◽  
Metallic Substrates ◽  
Ha Coating ◽  
Synthetic Hydroxyapatite

Synthetic Hydroxyapatite (HA) has been used as coating in order to enhance biocompatibility of titanium implants. Osseointegration at the implant-bone interface can be positively affected by the presence of HA coating and other biocompatible calcium phosphates (CaP) deposited on titanium implants, due to the high biocompatibility of these bioceramics. The biomimetic process is based on the nucleation and growth of a bioceramic film onto a substrate immersed in a body fluid solution (SBF) and it can be applied to deposit CaP coatings onto metallic substrates. The present work presents results on the characterization by SEM of CaP coating deposited on porous titanium samples by a biomimetic process.

Novel Micro-CT Based 3-Dimentional Structural Analyses of Porous Biomaterials

2007 ◽  
Vol 330-332 ◽  
pp. 967-970 ◽  
Author(s):  
B. Otsuki ◽  
Mitsuru Takemoto ◽  
Shunsuke Fujibayashi ◽  
Masashi Neo ◽  
Tadashi Kokubo ◽  
...  
Keyword(s):  
Network Structure ◽  
Bone Ingrowth ◽  
Average Pore Size ◽  
Three Dimensional ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Average Pore ◽  
Tissue Ingrowth ◽  
Porous Biomaterials

A porous structure comprises pores and pore throats with a complex three-dimensional network structure, and many investigators have described the relationship between average pore size and the amount of bone ingrowth. However, the influence of network structure or pore throats for tissue ingrowth has rarely been discussed. Bioactive porous titanium implants with 48% porosity were analyzed using specific algorithms for three-dimensional analysis of interconnectivity based on a micro focus X-ray computed tomography system. In vivo histological analysis was performed using the very same implants implanted into the femoral condyles of male rabbits for 6 weeks. This matching study revealed that more poorly differentiated pores tended to have narrow pore throats, especially in their shorter routes to the outside. Data obtained suggest that this sort of novel analysis is useful for evaluating bone and tissue ingrowth into porous biomaterials.

Hydroxyapatite nanoparticles in poly-D,L-lactic acid coatings on porous titanium implants conducts bone formation

2010 ◽  
Vol 95A (3) ◽  
pp. 665-672 ◽  
Author(s):  
Thomas Jensen ◽  
Thomas Jakobsen ◽  
Jørgen Baas ◽  
Jens V. Nygaard ◽  
Alireza Dolatshahi-Pirouz ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Bone Formation ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Hydroxyapatite Nanoparticles

Fabrication of bioactive 3D printed porous titanium implants with Sr ion-incorporated zeolite coatings for bone ingrowth

2018 ◽  
Vol 6 (20) ◽  
pp. 3254-3261 ◽  
Author(s):  
Shuang Wang ◽  
Ruiyan Li ◽  
Dongdong Li ◽  
Zhi-Yong Zhang ◽  
Guancong Liu ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
3D Printed ◽  
Strontium Ion ◽  
Zeolite Coatings

Strontium ion incorporated zeolites are uniformly fabricated on a 3D printed porous titanium scaffold for bone ingrowth.

scholarly journals Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Maryam Tamaddon ◽  
Sorousheh Samizadeh ◽  
Ling Wang ◽  
Gordon Blunn ◽  
Chaozong Liu
Keyword(s):  
Tissue Engineering ◽  
Bone Formation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Ingrowth ◽  
Selective Laser Sintering ◽  
Porous Titanium ◽  
Tissue Engineering Scaffolds ◽  
Alizarin Red

Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. Highly porous titanium scaffolds, produced by selective laser sintering with mechanical properties in range of trabecular bone (compressive strength 35 MPa and modulus 73 MPa), can be used in these orthopaedic applications, if a stable mechanical fixation is provided. Hydroxyapatite coatings are generally considered essential and/or beneficial for bone formation; however, debonding of the coatings is one of the main concerns. We hypothesised that the titanium scaffolds have an intrinsic potential to induce bone formation without the need for a hydroxyapatite coating. In this paper, titanium scaffolds coated with hydroxyapatite using electrochemical method were fabricated and osteoinductivity of coated and noncoated scaffolds was compared in vitro. Alizarin Red quantification confirmed osteogenesis independent of coating. Bone formation and ingrowth into the titanium scaffolds were evaluated in sheep stifle joints. The examinations after 3 months revealed 70% bone ingrowth into the scaffold confirming its osteoinductive capacity. It is shown that the developed titanium scaffold has an intrinsic capacity for bone formation and is a suitable scaffold for bone tissue engineering.

Migration, Matrix Production and Lamellar Bone Formation of Human Osteoblast-Like Cells in Porous Titanium Implants

2002 ◽  
Vol 170 (4) ◽  
pp. 214-227 ◽  
Author(s):  
K.-H. Frosch ◽  
F. Barvencik ◽  
C.H. Lohmann ◽  
V. Viereck ◽  
H. Siggelkow ◽  
...  
Keyword(s):  
Bone Formation ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Human Osteoblast ◽  
Lamellar Bone ◽  
Matrix Production

Bone ingrowth in porous titanium implants produced by 3D fiber deposition

Biomaterials ◽  
2007 ◽  
Vol 28 (18) ◽  
pp. 2810-2820 ◽  
Author(s):  
J LI ◽  
P HABIBOVIC ◽  
M VANDENDOEL ◽  
C WILSON ◽  
J DEWIJN ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Fiber Deposition

scholarly journals Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment

2016 ◽  
Vol 59 ◽  
pp. 690-701 ◽  
Author(s):  
Naoya Taniguchi ◽  
Shunsuke Fujibayashi ◽  
Mitsuru Takemoto ◽  
Kiyoyuki Sasaki ◽  
Bungo Otsuki ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Pore Size ◽  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
In Vivo Experiment
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