Long-term in vivo degradation behaviour and biocompatibility of the magnesium alloy ZEK100 for use as a biodegradable bone implant

2013 ◽  
Vol 9 (10) ◽  
pp. 8548-8560 ◽  
Author(s):  
Dina Dziuba ◽  
Andrea Meyer-Lindenberg ◽  
Jan Marten Seitz ◽  
Hazibullah Waizy ◽  
Nina Angrisani ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Degradation Behaviour ◽  
Bone Implant ◽  
In Vivo Degradation

In vivo degradation of binary magnesium alloys – a long-term study

2016 ◽  
Vol 17 (3-4) ◽  
Author(s):  
Anastasia Myrissa ◽  
Elisabeth Martinelli ◽  
Gábor Szakács ◽  
Leopold Berger ◽  
Johannes Eichler ◽  
...  
Keyword(s):  
Magnesium Alloys ◽  
Degradation Behavior ◽  
Sprague Dawley ◽  
Term Study ◽  
Bone Implant ◽  
Long Term Study ◽  
Interface Mechanics ◽  
In Vivo Degradation

AbstractBioresorbable magnesium materials are widely investigated because of their promising properties as orthopedic devices. Pure magnesium (99.99%) and two binary magnesium alloys (Mg2Ag and Mg10Gd) were used to investigate the degradation behavior, the bone adherence and bone-implant interface mechanics of these materials in growing Sprague-Dawley

scholarly journals Influence of the grain size on the in vivo degradation behaviour of the magnesium alloy LAE442

2013 ◽  
Vol 227 (3) ◽  
pp. 317-326 ◽  
Author(s):  
Berit Ullmann ◽  
Janin Reifenrath ◽  
Jan-Marten Seitz ◽  
Dirk Bormann ◽  
Andrea Meyer-Lindenberg
Keyword(s):  
Grain Size ◽  
Magnesium Alloy ◽  
Degradation Behaviour ◽  
In Vivo Degradation

In vivo degradation behavior of Ca-deficient hydroxyapatite coated Mg–Zn–Ca alloy for bone implant application

2011 ◽  
Vol 88 (1) ◽  
pp. 254-259 ◽  
Author(s):  
Huanxin Wang ◽  
Shaokang Guan ◽  
Yisheng Wang ◽  
Hongjian Liu ◽  
Haitao Wang ◽  
...  
Keyword(s):  
Degradation Behavior ◽  
Bone Implant ◽  
In Vivo Degradation

Comparison of the In Vivo Degradation Progress of Solid Magnesium Alloy Cylinders and Screw-Shaped Magnesium Alloy Cylinders in a Rabbit Model

2010 ◽  
Vol 638-642 ◽  
pp. 742-747 ◽  
Author(s):  
Nina von der Höh ◽  
Dirk Bormann ◽  
Arne Lucas ◽  
Fritz Thorey ◽  
Andrea Meyer-Lindenberg
Keyword(s):  
Magnesium Alloy ◽  
Pitting Corrosion ◽  
Femoral Condyle ◽  
Rabbit Model ◽  
Degradation Behavior ◽  
Gas Generation ◽  
Cross Sectional ◽  
Bone Implant ◽  
Computed Tomograph

Resorbable magnesium alloy implants for osteosynthetic surgery would be advantageous to common implants of titanium or surgical steel as a second surgery for implant removal would become unnecessary. To influence the degradation progress, surface modifications are sensible. As plates and screws were used to stabilize fractures, the degradation behavior of threaded cylinders is of particular interest. Therefore each eight solid MgCa0.8 alloy cylinders (3 x 5 mm) with smooth and sandblasted surface, respectively, and eight screw-shaped, threaded MgCa0.8 cylinders (thread pitch 1.25 mm, length 5 mm) were inserted into the medial femoral condyle of adult New Zealand White rabbits. Implantation periods were three and six months, within which the animals were examined daily. To evaluate a possible gas generation radiographs were taken weekly. After euthanasia the bone-implant-compound was scanned in a µ-computed tomograph (µCT80, ScancoMedical). All implants were well tolerated. Smooth implants degraded slowly. The cross sectional area did not reduce obviously after three months implantation duration and only mildly after six months. Sandblasted implants showed the fastest degradation progress after both implantation periods with the most obvious generation of gas. Threaded cylinders revealed pitting corrosion at the thread pitches. They degrade faster than smooth implants but slower than sandblasted cylinders. In summary, surface modification influences the degradation behavior of resorbable magnesium alloy implants. Contrary to common materials, smooth surfaces seem to be favorable. Thread pitches of screw-shaped implants show pitting corrosion. To what extend this result affects future applications of resorbable screws has to be examined in further investigations.

In vivo study of degradable magnesium and magnesium alloy as bone implant

2007 ◽  
Vol 1 (4) ◽  
pp. 405-409 ◽  
Author(s):  
Jingjing Huang ◽  
Yibin Ren ◽  
Yue Jiang ◽  
Bingchun Zhang ◽  
Ke Yang
Keyword(s):  
Magnesium Alloy ◽  
In Vivo Study ◽  
Bone Implant

scholarly journals Long-Term Biostability of Pet Vascular Prostheses

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Florence Dieval ◽  
Foued Khoffi ◽  
Riaz Mir ◽  
Walid Chaouch ◽  
Didier Le Nouen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Manufacturing Process ◽  
Vascular Prosthesis ◽  
Chemical Degradation ◽  
Medical Complications ◽  
Human Metabolism ◽  
Vascular Prostheses ◽  
In Vivo Degradation

PET Vascular prostheses are susceptible to physical modification and chemical degradation leading sometimes to global deterioration and rupture of the product. To understand the mechanisms of degradation, we studied 6 vascular prostheses that were explanted due to medical complications. We characterized their level of degradation by comparing them with a virgin prosthesis and carried out physicochemical and mechanical analyses. Results showed an important reduction of the fabric’s mechanical properties in specific areas. Moreover, PET taken from these areas exhibited structural anomalies and was highly degraded even in virgin prostheses. These results suggest that vascular prostheses have weak areas prior to implantation and that these areas are much more prone to in vivo degradation by human metabolism. Manufacturing process could be responsible for these weaknesses as well as designing of the compound. Therefore, we suggest that a more controlled manufacturing process could lead to a vascular prosthesis with enhanced lifespan.

The in vivo degradation and bone-implant interface of Mg-Nd-Zn-Zr alloy screws: 18 months post-operation results

2016 ◽  
Vol 113 ◽  
pp. 183-187 ◽  
Author(s):  
Jialin Niu ◽  
Meiping Xiong ◽  
Xingmin Guan ◽  
Jian Zhang ◽  
Hua Huang ◽  
...  
Keyword(s):  
Bone Implant ◽  
Post Operation ◽  
Operation Results ◽  
In Vivo Degradation ◽  
Zr Alloy
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