Folic acid mediated tumor targeting effect observed by fluorescent imaging

2012 ◽  
Vol 42 (8) ◽  
pp. 1172-1178
Author(s):  
Jun YUE ◽  
Rui WANG ◽  
XiuLi HU ◽  
XiaBin JING ◽  
Shi LIU
Keyword(s):  
Folic Acid ◽  
Tumor Targeting ◽  
Fluorescent Imaging ◽  
Targeting Effect

scholarly journals Lipoprotein-Inspired Nanocarrier Composed of Folic Acid-Modified Protein and Lipids: Preparation and Evaluation of Tumor-Targeting Effect

2020 ◽  
Vol Volume 15 ◽  
pp. 3433-3445
Author(s):  
Mengmeng Han ◽  
Xiaoman Ji ◽  
Jianfei Li ◽  
Zhiming Ge ◽  
Bin Luo ◽  
...  
Keyword(s):  
Folic Acid ◽  
Tumor Targeting ◽  
Targeting Effect ◽  
Preparation And Evaluation

scholarly journals Tumor Targeting Effect of Triphenylphosphonium Cations and Folic Acid Coated with Zr-89-Labeled Silica Nanoparticles

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2922
Author(s):  
Gun Gyun Kim ◽  
Jun Young Lee ◽  
Pyeong Seok Choi ◽  
Sang Wook Kim ◽  
Jeong Hoon Park
Keyword(s):  
Folic Acid ◽  
Membrane Potential ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Tumor Targeting ◽  
Particle Surface ◽  
Silanol Group ◽  
Radiochemical Yield ◽  
Drug Carriers ◽  
Targeting Effect

In this study, we investigated the tumor targeting effect in cancer cells using triphenylphosphonium (TPP) cations, which are accumulated by differences in membrane potential, and folic acid (FA), which is selectively bound to overexpressed receptors on various cancer cells. We used Food and Drug Administration (FDA)-approved silica nanoparticles (SNPs) as drug carriers, and SNPs conjugated with TPP and FA (STFs) samples were prepared by introducing different amounts of TPP and FA onto the nanoparticle surfaces. STF-1, 2, 3, 4 and 5 are named according to the combination ratio of TPP and FA on the particle surface. To confirm the tumor targeting effect, 89Zr (t1/2 = 3.3 days) was coordinated directly to the silanol group of SNP surfaces without chelators. It was shown that the radiochemical yield was 69% and radiochemical purity was >99%. In the cellular uptake evaluation, SNPs with the most TPP (SFT-5) and FA (SFT-1) attached indicated similar uptake tendencies for mouse colon cancer cells (CT-26). However, the results of the cell internalization assay and measurement of positron emission tomography (PET) images showed that SFT-5 had more affinity for the CT-26 tumor than other samples the TPP ratio of which was lower. Consequently, we confirmed that TPP ligands affect target cancer cells more than FA, which means that cell membrane potential is significantly effective for tumor targeting.

scholarly journals Novel albumin-binding photothermal agent ICG-IBA-RGD for targeted fluorescent imaging and photothermal therapy of cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 7226-7230
Author(s):  
Cheng Yu ◽  
Enhua Xiao ◽  
Pengfei Xu ◽  
Jingjing Lin ◽  
Linan Hu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Fluorescent Imaging ◽  
Albumin Binding

In this work, we present a novel photothermal agent ICG-IBA-RGD based on albumin-binding strategy for enhanced tumor targeting imaging and photothermal therapy.

scholarly journals Phosphorylcholine oligomer-grafted graphene oxide for tumor-targeting doxorubicin delivery

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41675-41685 ◽  
Author(s):  
Yu Qin ◽  
Changyu Wang ◽  
Yun Jiang ◽  
Tao Liu ◽  
Jianyong Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Tumor Targeting ◽  
Doxorubicin Delivery

Phosphorylcholine oligomer-grafted, folic acid-labeled and doxorubicin-loaded graphene oxide was found to be a potential versatile platform for biomarker-directed drug delivery with optimal biocompatibility.

Effective tumor-targeted delivery of etoposide using chitosan nanoparticles conjugated with folic acid and sulfobetaine methacrylate

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 91192-91200 ◽  
Author(s):  
Song Hua ◽  
Jiahua Yu ◽  
Jun Shang ◽  
Haowen Zhang ◽  
Jie Du ◽  
...  
Keyword(s):  
Folic Acid ◽  
Targeted Delivery ◽  
Tumor Targeting ◽  
Chitosan Nanoparticles

FA–CS(VP-16)-g-PSBMA nanoparticles were synthesized and showed effective tumor-targeting properties and promising anti-tumor capacity in vivo.

Multifunctional nanosheets based on folic acid modified manganese oxide for tumor-targeting theranostic application

2015 ◽  
Vol 27 (2) ◽  
pp. 025101 ◽  
Author(s):  
Yongwei Hao ◽  
Lei Wang ◽  
Bingxiang Zhang ◽  
Hongjuan Zhao ◽  
Mengya Niu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Manganese Oxide ◽  
Tumor Targeting
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