scholarly journals Novel albumin-binding photothermal agent ICG-IBA-RGD for targeted fluorescent imaging and photothermal therapy of cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 7226-7230
Author(s):  
Cheng Yu ◽  
Enhua Xiao ◽  
Pengfei Xu ◽  
Jingjing Lin ◽  
Linan Hu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Fluorescent Imaging ◽  
Albumin Binding

In this work, we present a novel photothermal agent ICG-IBA-RGD based on albumin-binding strategy for enhanced tumor targeting imaging and photothermal therapy.

Multifunctional Nanosystem Based on Graphene Oxide for Synergistic Multistage Tumor-Targeting and Combined Chemo-Photothermal Therapy

2019 ◽  
Vol 16 (5) ◽  
pp. 1982-1998 ◽  
Author(s):  
Huabing Zhang ◽  
Yang Li ◽  
Zhou Pan ◽  
Yilin Chen ◽  
Zhongxiong Fan ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Photothermal Therapy ◽  
Tumor Targeting

Small fluorescent albumin nanoparticles for targeted photothermal therapy via albumin-Binding protein pathways

2019 ◽  
Vol 181 ◽  
pp. 696-704 ◽  
Author(s):  
Ke Wang ◽  
Xi Liu ◽  
Jialang Zhuang ◽  
Yubing Liu ◽  
Maosheng Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Binding Protein ◽  
Albumin Binding ◽  
Albumin Nanoparticles

Enzyme-responsive multifunctional peptide coating of gold nanorods improves tumor targeting and photothermal therapy efficacy

2019 ◽  
Vol 86 ◽  
pp. 363-372 ◽  
Author(s):  
Liming Wu ◽  
Bingyi Lin ◽  
Huang Yang ◽  
Jing Chen ◽  
Zhengwei Mao ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Therapy Efficacy ◽  
Peptide Coating

Shape tunable gallium nanorods mediated tumor enhanced ablation through near-infrared photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 2655-2667 ◽  
Author(s):  
Xuyang Sun ◽  
Mengmeng Sun ◽  
Miaomiao Liu ◽  
Bo Yuan ◽  
Weiping Gao ◽  
...  
Keyword(s):  
Liquid Metal ◽  
Metal Nanoparticles ◽  
Conversion Efficiency ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Photothermal Conversion

Shape tunable liquid metal nanoparticles were fabricated with characterization of biocompatibility, favorable photothermal conversion efficiency and tumor targeting capability for photothermal therapy.

scholarly journals Gold Nanorod Bioconjugates for Active Tumor Targeting and Photothermal Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hadiyah N. Green ◽  
Dmitry V. Martyshkin ◽  
Cynthia M. Rodenburg ◽  
Eben L. Rosenthal ◽  
Sergey B. Mirov
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Photothermal Effect ◽  
Specific Antibodies ◽  
Before And After ◽  
Egfr Antibody

The mastery of active tumor targeting is a great challenge in near infrared photothermal therapy (NIRPTT). To improve efficiency for targeted treatment of malignant tumors, we modify the technique of conjugating gold nanoparticles to tumor-specific antibodies. Polyethylene glycol-coated (PEGylated) gold nanorods (GNRs) were fabricated and conjugated to an anti-EGFR antibody. We characterized the conjugation efficiency of the GNRs by comparing the efficiency of antibody binding and the photothermal effect of the GNRs before and after conjugation. We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.

Application of Gold-Based Nanomaterials in Tumor Photothermal Therapy and Chemotherapy

2020 ◽  
Vol 16 (6) ◽  
pp. 739-762
Author(s):  
Minyu Zhou ◽  
Yunfei Zhou ◽  
Yixin Cheng ◽  
Yanqi Wu ◽  
Jun Yang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Tumor Tissue ◽  
Treatment Method ◽  
Tumor Treatment ◽  
Targeting Therapy ◽  
Photothermal Conversion ◽  
Gold Nanomaterials ◽  
Development Prospects ◽  
Therapy Treatment

Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.

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