scholarly journals Investigation of Metal(II)-Curcumin-Glycine Complexes : Preparation, Structural Characterization and Biological Activities

2021 ◽  
Vol 37 (2) ◽  
pp. 397-404
Author(s):  
M. Vimala Joice ◽  
P. Metilda Metilda
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activities ◽  
Metal Chelate ◽  
Bacterial Species ◽  
Molar Conductance ◽  
Metal Chelates ◽  
Magnetic Data ◽  
Planar Geometry ◽  
Tetrahedral Geometry ◽  
E Coli

A novel Schiff base obtained from curcumin and glycine was prepared and it was reacted with Co, Ni, Cu and Zn metals in order to form the stable metal complexes and characterized by elemental analysis, magnetic, molar conductance, IR, UV-Vis.,1H NMR and PXRD. The data shows that the complexes have the structure [M(II)-(cur-gly)H2O] system Electronic and magnetic data suggest a tetrahedral geometry for Co, Ni and Zn except Cu complex has a square planar geometry. The antimicrobial activity of cur-gly and its metal chelates were confirmed against the bacterial species as E. coli, P. aeruginosa, Enterococcus, B. cereus and S. aureus species. Antifungal activity was screened against C. albicans, C. parapsilosis and A. flavus. Metal chelates indicate excellent antimicrobial activity than their parent cur-gly and DNA photo cleavage activity shows that metal chelate effectively cleave the pUC 18 DNA.

Substituted 6,7-dimethoxy-5-oxo-2,3,5,9b-tetrahydrothiazolo[2,3-a]isoindole- 3-1,1-dioxide Derivatives with Antimicrobial Activity and Docking Assisted Prediction of the Mechanism of their Antibacterial and Antifungal Properties

2020 ◽  
Vol 20 (29) ◽  
pp. 2681-2691
Author(s):  
Athina Geronikaki ◽  
Victor Kartsev ◽  
Phaedra Eleftheriou ◽  
Anthi Petrou ◽  
Jasmina Glamočlija ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Drug Targets ◽  
Bacterial Species ◽  
Pharmaceutical Research ◽  
Docking Studies ◽  
Fungal Species ◽  
Docking Analysis ◽  
E Coli ◽  
Antibacterial And Antifungal

Background: Although a great number of the targets of antimicrobial therapy have been achieved, it remains among the first fields of pharmaceutical research, mainly because of the development of resistant strains. Docking analysis may be an important tool in the research for the development of more effective agents against specific drug targets or multi-target agents 1-3. Methods: In the present study, based on docking analysis, ten tetrahydrothiazolo[2,3-a]isoindole derivatives were chosen for the evaluation of the antimicrobial activity. Results: All compounds showed antibacterial activity against eight Gram-positive and Gram-negative bacterial species being, in some cases, more potent than ampicillin and streptomycin against all species. The most sensitive bacteria appeared to be S. aureus and En. Cloacae, while M. flavus, E. coli and P. aeruginosa were the most resistant ones. The compounds were also tested for their antifungal activity against eight fungal species. All compounds exhibited good antifungal activity better than reference drugs bifonazole (1.4 – 41 folds) and ketoconazole (1.1 – 406 folds) against all fungal species. In order to elucidate the mechanism of action, docking studies on different antimicrobial targets were performed. Conclusion: According to docking analysis, the antifungal activity can be explained by the inhibition of the CYP51 enzyme for most compounds with a better correlation of the results obtained for the P.v.c. strain (linear regression between estimated binding Energy and log(1/MIC) with R 2 =0.867 and p=0.000091 or R 2 = 0.924, p= 0.000036, when compound 3 is excluded.

scholarly journals Betalains in Edible Fruits of Three Cactaceae Taxa—Epiphyllum, Hylocereus, and Opuntia—Their LC-MS/MS and FTIR Identification and Biological Activities Evaluation

Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2669
Author(s):  
Michaela Barkociová ◽  
Jaroslav Tóth ◽  
Katarzyna Sutor ◽  
Natalia Drobnicka ◽  
Slawomir Wybraniec ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Food Industry ◽  
Biological Activities ◽  
Ornamental Plants ◽  
Reducing Power ◽  
Activity Assay ◽  
Natural Pigment ◽  
E Coli ◽  
Ft Ir

Epiphyllum, Hylocereus, and Opuntia plants belong to the Cactaceae family. They are mostly known as ornamental plants but also for their edible fruits, which can potentially be sources of betalains, such as betanin, a natural pigment used in the food industry, e.g., under the European label code E 162. The aim of this work was the identification of betalains (using LC-MS/MS), evaluation of total betalain content (spectrophotometrically), analysis of functional groups (using FT-IR), evaluation of antioxidant activity (using DPPH, ABTS, FRAP, DCFH-DA, and reducing power methods) and evaluation of antimicrobial activity (S. aureus, E. coli, and C. albicans) in fruits of Epiphyllum, Hylocereus, and Opuntia taxa. A total of 20 betalains were identified in the studied Cactaceae fruits. The Epiphyllum pink hybrid had the highest values of total betalains amongst all samples. The highest antioxidant activity was observed in the Epiphyllum pink hybrid, in Opuntia zacuapanensis and O. humifusa fruits. The antimicrobial activity assay showed that cacti fruits were not able to effectively inhibit the growth of E. coli, S. aureus, or C. albicans. Our results prove that these fruits are good sources of natural pigments—betalains. They do not contain toxic compounds in significant amounts and they exhibit antioxidant activity.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

Antioxidant and Antimicrobial Activities of the Fresh aerial parts of Ammi visnaga L. from Algeria

2016 ◽  
Vol 6 (2) ◽  
pp. 70-76
Author(s):  
Soumia Keddari ◽  
Narimen Benaoum ◽  
Yasmina Mokhtaria Boufadi ◽  
Mansouria Belhocine ◽  
Ali Riazi
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Phenolic Compounds ◽  
Biological Activities ◽  
Antibacterial Properties ◽  
Ethanolic Extract ◽  
Diffusion Method ◽  
E Coli ◽  
Ammi Visnaga ◽  
Wide Range

Medicinal plants have been used for countries as cures for human diseases because they contain components of therapeutic value. Among these medi-cinal plants, Ammi visnage which have an immense reservoir of potential compounds attributed to the secondary metabolites which have the advan-tage of being of great diversity of chemical structure and have a very wide range of biological activities. The objectives of the present work were to stu-dy the antioxidant and antimicrobial activity of phenolic compounds ex-tracted from A. visnaga L. Its extraction is performed by two methods, etha-nol extraction and water extraction. The results showed that A. visnaga L.. ethanolic extract contains a mixture of phytochemical classes as polyphenol, flavonoids and revealed that this plant has high antioxidant activity (IC50 0.069 mg/ml). Regarding the antimicrobial activity results expressed by the diameter of the inhibition zones by diffusion method AWDT, the most signifi-cant inhibition was observed against to Staphylococcus aureus (12 mm) to the ethanol extract at concentration of 100mg / ml. Thus the aqueous ex-tract had a significant inhibitory activity against on the strains Staphylococ-cus aureus (8 mm), E. coli ATCC 10536 (8 mm) to a concentration of 100 mg / ml. The results for the antibacterial properties have shown that Gram-positive bacteria (Staphylococcus aureus, Listeria monocytogenes and M. luteus.) were more sensitive than gram-negative (Pseudomonas aeruginosa, E. coli ATCC 10536) against from the action of phenolic compounds of the Ammi visnaga ethanolic extract.

scholarly journals Synthesis, Antimicrobial Activity and Molecular Docking of Novel Thiourea Derivatives Tagged with Thiadiazole, Imidazole and Triazine Moieties as Potential DNA Gyrase and Topoisomerase IV Inhibitors

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2766 ◽  
Author(s):  
Heba E. Hashem ◽  
Abd El-Galil E. Amr ◽  
Eman S. Nossier ◽  
Elsayed A. Elsayed ◽  
Eman M. Azmy
Keyword(s):  
Antimicrobial Activity ◽  
Molecular Docking ◽  
Antimicrobial Agents ◽  
Biological Activities ◽  
Topoisomerase Iv ◽  
Thiourea Derivatives ◽  
E Coli ◽  
Cytotoxicity Studies ◽  
Ic50 Values

To develop new antimicrobial agents, a series of novel thiourea derivatives incorporated with different moieties 2–13 was designed and synthesized and their biological activities were evaluated. Compounds 7a, 7b and 8 exhibited excellent antimicrobial activity against all Gram-positive and Gram-negative bacteria, and the fungal Aspergillus flavus with minimum inhibitory concentration (MIC) values ranged from 0.95 ± 0.22 to 3.25 ± 1.00 μg/mL. Furthermore, cytotoxicity studies against MCF-7 cells revealed that compounds 7a and 7b were the most potent with IC50 values of 10.17 ± 0.65 and 11.59 ± 0.59 μM, respectively. On the other hand, the tested compounds were less toxic against normal kidney epithelial cell lines (Vero cells). The in vitro enzyme inhibition assay of 8 displayed excellent inhibitory activity against Escherichia coli DNA B gyrase and moderate one against E. coli Topoisomerase IV (IC50 = 0.33 ± 1.25 and 19.72 ± 1.00 µM, respectively) in comparison with novobiocin (IC50 values 0.28 ± 1.45 and 10.65 ± 1.02 µM, respectively). Finally, the molecular docking was done to position compound 8 into the E. coli DNA B and Topoisomerase IV active pockets to explore the probable binding conformation. In summary, compound 8 may serve as a potential dual E. coli DNA B and Topoisomerase IV inhibitor.

scholarly journals Physico-chemical and biological studies of Cu(II), Co(II) and Ni(II) complexes of an N4 coordinating ligand derived from diacetylbisethylenediamine and benzoic acid

2012 ◽  
Vol 77 (5) ◽  
pp. 627-637 ◽  
Author(s):  
Pal Singh ◽  
Nanda Srivastava
Keyword(s):  
Benzoic Acid ◽  
Metal Complexes ◽  
Magnetic Moment ◽  
Biological Activities ◽  
Molar Conductance ◽  
Planar Geometry ◽  
Cyclic Voltammetric Study ◽  
Biological Studies ◽  
Antibacterial And Antifungal

Mononuclear metal complexes of the type [ML1]Cl2 (where, M = = Cu(II), Co(II) or Ni(II) and L1 = ligand) were synthesized by the reaction of a new N4 coordinating ligand, derived from diacetylbisethylenediamine with benzoic acid, and the corresponding hydrated metal chloride salts. The metal complexes were characterized by elemental analysis, melting point determination, molar conductance and magnetic moment measurements, IR, UV-Vis, 1H- and 13C-NMR, and ESR spectroscopy. The ligand and all the metal complexes were stable in the solid state at room temperature. From the analytical and spectroscopic investigations, the stoichiometry of the complexes was found to be 1:1 (metal:ligand). Based on the electronic spectra and magnetic moment data, the metal complexes had a square planar geometry. The molar conductance values show the 1:2 electrolytic nature of the metal complexes. A cyclic voltammetric study of the Cu(II) metal complex has also performed, which showed one electron quasi-reversible reduction around -0.92 to -1.10 V. In vitro biological activities of the ligand and metal complexes was checked against two bacteria Bacillus subtilis and Escherichia coli and two fungi Aspirgillus niger and A. flavus which showed the antibacterial and antifungal properties of the ligand and its metal complexes.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of 3-[(2-Hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one and its Metal(II) Complexes

2008 ◽  
Vol 5 (1) ◽  
pp. 155-162 ◽  
Author(s):  
K. Siddappa ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML2 and M′L [where M=Cu(II), Co(II), and Ni(II) and M′= Zn(II), Cd(II) and Hg(II)]. L = 3-[(2-hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one, (HQMAPQ) Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HQMAPQ acts as doubly monodentate bridge for metal(II) ions and form mononuclear complexes. The complexes Ni(II), Co(II) and Cu(II) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal(II) complexes were screened for their antimicrobial activity.

scholarly journals Biological activities (antioxidant and antimicrobial activity) of the aqueous extracts and essential oil of Ammoides verticillata (Nounkha)

2018 ◽  
Vol 75 (2) ◽  
pp. 64
Author(s):  
Ramdane MOHAMED SAID ◽  
Nabahat BENMANSOUR
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Biological Activities ◽  
Stable Free Radical ◽  
E Coli ◽  
Highly Sensitive ◽  
Clinical Action ◽  
Ammoides Verticillata ◽  
Antioxidant And Antimicrobial Activity ◽  
Low Activity

The phytochemical review conducted on the aerial part Ammoides verticillata has revealed the presence of six chemical families: flavonoids, tannins; gallic tannins, anthocyanins and the coumarins, cateichic tannins. The aqueous extract of the Ammoides verticillata could bring back the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) to the yellow-colored diphenylpicrylhydrazine with an IC50 of 0.020 mg.mL-1. It is gifted with antioxidant activity, however it was less effective than vitamin C (0.001 mL-1). The essential oil of the Ammoides verticillata has presented a strong antimicrobial activity against Gram negatif germs targets of original clinical action: E. coli (ESBL) (37 mm), E. coli (39.5 mm), Klebsiella pneumoniae (36.5 mm) and especially with the yeast: Candida albicans ATCC 10231 (47 mm) and Saccharomyces cerevisie ATCC (42 mm), which are highly sensitive to the oil inhibitory action. However, the oil has presented a low activity against the bacteria P. aeruginosa (12.5 mm).

A Study on Electrochemical, Catalytic and Biological Properties of New Nickel Coordinated Schiff Base Materials

2013 ◽  
Vol 16 (2) ◽  
pp. 109-114
Author(s):  
S. Asha Jebamary ◽  
R. Antony ◽  
S. Theodore David ◽  
K. Karuppasamy ◽  
S. Thanikaikarasan ◽  
...  
Keyword(s):  
Schiff Base ◽  
Biological Activities ◽  
Biological Properties ◽  
Molar Conductance ◽  
Planar Geometry ◽  
Bacterial Strains ◽  
Molar Ratios ◽  
Base Materials ◽  
Elemental Analyses ◽  
Ft Ir

Four new Schiff bases have been derived from the condensation of acenapthoquinone and naphthylamines in 1:2 molar ratios. These Schiff base ligands were used to synthesise novel mononuclear Ni(II) complexes with square planar geometry. The ligands and the complexes have been investigated by elemental analyses, spectroscopic methods (FT-IR and UV-Vis.,), molar conductance and magnetic susceptibility studies. The electrochemical properties of Ni(II) complexes have been studied by cyclic voltammetry technique. The catalytic efficacy of the complexes has been analysed in the oxidation of toluene to benzyl alcohol, using H2O2. Biological activities of these ligands and complexes were checked against selected bacterial strains (E. coli and S. Aureus).

scholarly journals Synthesis, Thermal Characterization and in vitro Antibacterial Assessment of Co(II) and Cd(II) Complexes of Schiff Base Derived from Amoxicillin and Thiophene-2-carbaldehyde

2019 ◽  
Vol 31 (4) ◽  
pp. 951-959 ◽  
Author(s):  
N.K. Chaudhary ◽  
B. Guragain
Keyword(s):  
Metal Complexes ◽  
Biological Activities ◽  
Geometry Optimization ◽  
Thermal Characterization ◽  
Molar Conductance ◽  
Sem Analysis ◽  
Biological Data ◽  
Spectral Studies ◽  
Tetrahedral Geometry

A novel AMXTC2 ligand was prepared by simultaneous stirring and refluxing of an equimolar mixture of amoxicillin and thiophene-2-carbaldehyde in methanol and was further used to synthesize metal complexes by metalation with cobalt and cadmium salts, taking ligand metal ratio 2:1. They were characterized by elemental microanalysis, FT-IR, mass, UV-visible, 1H NMR, thermal analysis, magnetic moment and molar conductance measurements. The coordination sites in the ligand were verified by their comparative and extensive spectral studies. The detailed exploration of the data suggested octahedral geometry for Co-AMXTC2 and tetrahedral geometry for Cd-AMXTC2 complexes. The thermodynamic and kinetic parameters such as E*, ΔH*, ΔS* and ΔG* of various decomposition steps were calculated from TGA curves using the Coats-Redfern method. The molar conductivity data suggested non-electrolytic nature of the complexes. SEM analysis was done to observe their surface morphology. The geometry optimization of the proposed molecular structure of the complexes was achieved by running MM2 calculation in Gaussian supported Cs-ChemOffice Ultra-11 program software. The biological activities had been evaluated in vitro against E. coli, K. pneumonia, P. vulgaris and S. aureus pathogens in order to assess their antibacterial potency. The biological data revealed better growth inhibitory action of the ligand and metal complexes with bacterial pathogens.

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