scholarly journals Synthesis, Characterization and Antimicrobial Studies of N1-[(1E)-1-(2-Hydroxyphenyl) ethylidene]-2-oxo-2H-chromene-3-carbohydrazide and its Metal Complexes

2009 ◽  
Vol 6 (3) ◽  
pp. 615-624 ◽  
Author(s):  
K. Siddappa ◽  
K. Mallikarjun ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Metal Complexes ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML, MʹL and M″L [where M=Cu(II), Co(II), Ni(II) and Mn(II), Mʹ=Fe(III) and M″=Zn(II), Cd(II) and Hg(II) and L=N1-[(1E)-1-(2-hydroxyphenyl)ethylidene]-2-oxo-2H-chromene- 3-carbohydrazide (HL)] Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HL acts as doubly monodentate bridge for metal ions and form mononuclear complexes. The complexes Ni(II), Co(II), Cu(II) Mn(II) and Fe(III) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal complexes were screened for their antimicrobial activity.

scholarly journals Synthesis, Characterization and Antimicrobial Studies of 3-[(2-Hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one and its Metal(II) Complexes

2008 ◽  
Vol 5 (1) ◽  
pp. 155-162 ◽  
Author(s):  
K. Siddappa ◽  
Tukaram Reddy ◽  
M. Mallikarjun ◽  
C. V. Reddy
Keyword(s):  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Molar Conductance ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Mononuclear Complexes ◽  
Uv Visible

A new complexes of the type ML2 and M′L [where M=Cu(II), Co(II), and Ni(II) and M′= Zn(II), Cd(II) and Hg(II)]. L = 3-[(2-hydroxy-quinolin-3-ylmethylene)-amino]-2-phenyl-3H-quinazolin-4-one, (HQMAPQ) Schiff base have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR,1H NMR, UV-Visible and ESR data. The studies indicate the HQMAPQ acts as doubly monodentate bridge for metal(II) ions and form mononuclear complexes. The complexes Ni(II), Co(II) and Cu(II) complexes are found to be octahedral, where as Zn(II), Cd(II) and Hg(II) complexes are four coordinated with tetrahedral geometry. The synthesized ligand and its metal(II) complexes were screened for their antimicrobial activity.

scholarly journals Synthesis and Characterization of New Lead(II) and Organotin(IV) Complexes of Schiff Bases Derived from Histidine and Methionine

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Har Lal Singh ◽  
J. B. Singh
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Analytical Data ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Carboxylate Oxygen

New Schiff base (HL) ligand is prepared via condensation of isatins and amino acids in 1:1 molar ratio. Metal complexes are prepared and characterized by elemental analysis, molar conductance, electronic, infrared, and multinuclear magnetic resonance (1H NMR, 13C NMR, and 119Sn NMR). The analytical data showed that the ligand acts as bidentate toward metal ions via azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of metal : ligand (1 : 2) to from metal complexes (Pb(II)(L)2 and Bu2Sn(L)2, where L is the Schiff base ligands of histidine and methionine). The conductivity values between 15 and 25 Ω−1cm2 mol−1 in DMF imply the presence of nonelectrolyte species. On the basis of the above spectral studies, distorted octahedral and tetrahedral geometry have been proposed for the resulting organotin(IV) and lead(II) complexes.

scholarly journals Transition Metal Complexes of Methyl-quinolino[3,2-b][1,5]benzodiazepine and Methylquinolino [3,2-b][1,5]benzoxazepine: Synthesis, Characterisation and Antimicrobial Studies

2007 ◽  
Vol 4 (1) ◽  
pp. 39-45
Author(s):  
B. Basavaraju ◽  
H. S. Bhojya Naik ◽  
M. C. Prabhakara
Keyword(s):  
Antifungal Activity ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Molar Conductance ◽  
Antibacterial And Antifungal Activity ◽  
Magnetic Studies ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Uv Visible ◽  
Antibacterial And Antifungal

The synthesis and characterisation of title complexes of the ligand Methylquinolino[3,2-b][1,5]benzodiazepine (MQBD) and Methyl-quinolino[3,2-b][1,5]benzoxazepine (MQBO) are reported. The complexes have been characterized by elemental analysis, molar conductance, magnetic studies, IR,1H NMR and UV-visible studies. They have the stoichiometry [ML2Cl2] where M=Co(II)/Ni(II), L=MQBD/MQBO and [MLCl2] where M=Zn(II)/Cd(II), L=MQBD/MQBO. The antibacterial and antifungal activity of the metal complexes has been investigated.

scholarly journals Synthesis and Spectroscopic and Antimicrobial Studies of Schiff Base Metal Complexes Derived from 2-Hydroxy-3-methoxy-5-nitrobenzaldehyde

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
K. R. Joshi ◽  
A. J. Rojivadiya ◽  
J. H. Pandya
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Dilution Method ◽  
Aspergillus Clavatus ◽  
Schiff Base Ligands ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
Schiff Base Metal Complexes ◽  
Broth Dilution

Two new series of copper(II) and nickel(II) complexes with two new Schiff base ligands 2-((2,4-dimethylphenylimino)methyl)-6-methoxy-4-nitrophenol and 2-((3,4-difluorophenylimino)methyl)-6-methoxy-4-nitrophenol have been prepared. The Schiff base ligands were synthesized by the condensation of 2-hydroxy-3-methoxy-5-nitrobenzaldehyde with 2,4-dimethylaniline or 3,4-difluoroaniline. The ligands and their metal complexes have been characterized by IR, 1H NMR, mass and electronic spectra and TG analysis. The Schiff base ligands and their metal complexes were tested for antimicrobial activity against Gram positive bacteria Staphylococcus aureus, and Streptococcus pyogenes and Gram negative bacteria Escherichia coli, and Pseudomonas aeruginosa and fungus Candida albicans, Aspergillus niger, and Aspergillus clavatus using Broth Dilution Method.

scholarly journals Synthesis Characterization and Antimicrobial Activity Studies of Some Transition Metal Complexes Derived from 3-Chloro-N′-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Vivekanand D. Biradar ◽  
B. H. M. Mruthyunjayaswamy
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Esr Spectra ◽  
Mass Spectral Data ◽  
Tetrahedral Geometry ◽  
Donor Ligand ◽  
Mass Spectral ◽  
E Coli ◽  
H Nmr

A series of new coordination complexes of Cu(II), Co(II), Ni(II), Zn(II), Hg(II), Mn(II), and Fe(III) with the Schiff base 3-chloro-N′-[(1E)-(2-hydroxy phenyl)methylene]-6-methoxy-1-benzothiophene-2-carbohydrazide (HL) have been synthesized and characterized by elemental analysis, electrical conductivity measurements, IR spectra,1H NMR, mass spectral data, electronic spectra, magnetic susceptibility, ESR spectra, TGA, and Powder XRD data. The Schiff base behaves as tridentate ONO donor ligand and forms the complexes of the type ML2(metal-ligand) stoichiometry for Cu(II), Co(II), Ni(II), and Mn(II) complexes and ML stoichiometry for Zn(II), Hg(II), and Fe(III) complexes. All the complexes are colored and nonelectrolytes. It is found that Cu(II), Co(II), Ni(II), Mn(II) and Fe(III) complexes have exhibited octahedral geometry whereas Zn(II) and Hg(II) complexes exhibited tetrahedral geometry. The ligand and its metal complexes have been screened for their antibacterial activity againstE. coliandS. aureusand antifungal activity againstA. nigerandA. flavus.

scholarly journals Metal Complexes of a Novel Schiff Base Based on Penicillin: Characterization, Molecular Modeling, and Antibacterial Activity Study

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Narendra Kumar Chaudhary ◽  
Parashuram Mishra
Keyword(s):  
Thermal Stability ◽  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Parent Drug ◽  
Molar Conductance ◽  
Kinetic Properties ◽  
Field Calculation ◽  
Tetrahedral Geometry

A novel Schiff base ligand of type HL was prepared by the condensation of amoxicillin trihydrate and nicotinaldehyde. The metal complexes of Co+2, Ni+2, Cu+2, and Zn+2 were characterized and investigated by physical and spectral techniques, namely, elemental analysis, melting point, conductivity, 1H NMR, IR, UV-Vis spectra, ESR, SEM, and mass spectrometry measurements. They were further analyzed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes. Thermal data revealed high thermal stability and nonspontaneous nature of the decomposition steps. The Coats-Redfern method was applied to extract thermodynamic parameters to explain the kinetic behavior. The molar conductance values were relatively low, showing their nonelectrolytic nature. The powder XRD pattern revealed amorphous nature except copper complex (1c) that crystallized in the triclinic crystal system. The EPR study strongly recommends the tetrahedral geometry of 1c. The structure optimization by MM force field calculation through ArgusLab 4.0.1 software program supports the concerned geometry of the complexes. The in vitro antibacterial activity of all the compounds, at their two different concentrations, was screened against four bacterial pathogens, namely, E. coli, P. vulgaris, K. pneumoniae, and S. aureus, and showed better activity compared to parent drug and control drug.

scholarly journals Microwave Synthesis, Spectral, Thermal and Antimicrobial Studies of Some Co(II), Ni(II) and Cu(II) Complexes Containing 2-Aminothiazole Moiety

2012 ◽  
Vol 9 (4) ◽  
pp. 1655-1666 ◽  
Author(s):  
A. P. Mishra ◽  
H. Purwar ◽  
Rajendra K. Jain ◽  
S. K. Gupta
Keyword(s):  
Electrical Conductivity ◽  
Schiff Base ◽  
Solid State ◽  
Metal Complexes ◽  
Analytical Data ◽  
Xrd Analysis ◽  
Lattice Parameter ◽  
Molar Conductance ◽  
Unit Cell ◽  
Antimicrobial Studies

Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 4-chlorobenzylidene-2-aminothiazole (CAT) and 2-nitrobenzylidene-2-aminothiazole (NAT) have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ESR, magnetic susceptibility, thermal, electrical conductivity and XRD analysis. The complexes are coloured and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal:ligand) ratio with coordination number 4 or 6. FAB-mass and thermal data show degradation pattern of the complexes. The thermal behavior of metal complexes shows that the hydrated complexes loses water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. The crystal system, lattice parameter, unit cell volume and number of molecules in unit cell in the lattice of complexes have been determined by XRD analysis. XRD patterns indicate crystalline nature for the complexes. The solid state electrical conductivity of the metal complexes has also been measured. Solid state electrical conductivity studies reflect semiconducting nature of the complexes. The Schiff base and metal complexes show a good activity against the Gram-positive bacteria;Staphylococcus aureusand Gram-negative bacteria;Escherichia coliand fungiAspergillus nigerandCandida albicans.

scholarly journals Spectral, Magnetic and Biological Studie on Some Bivalent 3d Metal Complexes of Hydrazine Derived Schiff-Base Ligands

1997 ◽  
Vol 4 (2) ◽  
pp. 65-68 ◽  
Author(s):  
Zahid H. Chohan ◽  
Syed K. A. Sherazi
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Elemental Analysis ◽  
Magnetic Moment ◽  
Bacterial Species ◽  
Biological Properties ◽  
Molar Conductance ◽  
Schiff Base Ligands ◽  
H Nmr ◽  
3D Metal Complexes

Metal(II) complexes of hydrazine derived Schiff-base ligands of the type M(L)2Cl2 where M = Co, Cu, Ni and Zn and L = L1 and L2 have been prepared and characterised by molar conductance, magnetic moment, elemental analysis and electronic, IR, H-NMR and C13 spectral data.The different modes of chelation of the ligands and their comparative biological properties against different bacterial species are reported.

scholarly journals Coordination Modes of a Schiff Base Derived from Substituted 2-Aminothiazole with Chromium(III), Manganese(II), Iron(II), Cobalt(II), Nickel(II) and Copper(II) Metal Ions: Synthesis, Spectroscopic and Antimicrobial Studies

2011 ◽  
Vol 8 (4) ◽  
pp. 1750-1764 ◽  
Author(s):  
Ambit Thakar ◽  
Krishnakant Joshi ◽  
Kishor Pandya ◽  
Arvind Pancholi
Keyword(s):  
Schiff Base ◽  
Metal Ions ◽  
Transition Metal Complexes ◽  
Mass Spectra ◽  
Antibacterial Activities ◽  
Molar Conductance ◽  
Spectral Techniques ◽  
H Nmr ◽  
Antimicrobial Studies ◽  
C Nmr

Transition metal complexes of Cr(III), Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) metal ions with general stoichiometry [ML2.2H2O] and [ML3], where M= Mn(II), Cr(III), Fe(II), Co(II), Ni(II) and Cu(II), L= Schiff base derived from the condensation of 2-amino-4(4’-phenyl/methylphenyl)-5-methyl-thiazole with 4-acetyl-1(3-chloro phenyl)-3-methyl-2-pyrazoline-5-ones, have been synthesized and structurally characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements and spectral techniques like IR, UV,1H NMR,13C NMR and Mass Spectra. All the complexes were found to be octahedral geometry. The ligand and its complexes have been screened for their antifungal and antibacterial activities against three fungi,i.e. Alternaria brassicae, Aspergillus nigerandFesarium oxysporumand two bacteria,i.e. Xanthomonas compestrisandPseudomonas aeruginosa.

scholarly journals Synthesis, characterization and antimicrobial studies of Mn(II) complexes of acetylthiophene and acetyl furan Schiff base derivatives

2020 ◽  
Vol 12 (1) ◽  
pp. 251-258
Author(s):  
S. Isyaku ◽  
H.N. Aliyu ◽  
E.C. Ozoro ◽  
T. Abubakar
Keyword(s):  
Magnetic Susceptibility ◽  
Schiff Base ◽  
Schiff Bases ◽  
Elemental Analysis ◽  
Salmonella Typhi ◽  
Decomposition Temperature ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Antimicrobial Studies

Manganese(II) complexes of Schiff bases; 2-acetylthiophene-4‑phenylthiosemi-carbazone (AT-PTSC) and 2-furylmethylketone-4-phenylthiosemi-carbazone  (AF‑PTSC) derived from condensation of 2-acetylthiophene and 2-furylmethylketone (2-acetylfuran) each with 4-phenylthiosemicarbazide in (1:1 molar ratio) ethanol, have been synthesized. The Schiff bases and the Mn(II) complexes were characterized on the basis of melting point/decomposition temperature, solubility, magnetic susceptibility, infrared spectra, molar conductance measurements,  elemental and gravimetric  analyses. The Mn(II) complexes show moderate values of decomposition temperatures. The Schiff bases and the complexes were soluble in some common organic solvents. Infrared spectral data of the Schiff bases and their complexes, indicate coordination of the Schiff bases to the metal(II) ion via azomethine nitrogen. The effective magnetic moment of the Mn(II) complexes suggested an octahedral geometry. The molar conductance values of the complexes show that the complexes are electrolytes. The results of the elemental analysis of the ligands and their complexes are in good agreement with the calculated values, suggesting a 1:2 (metal-ligand) ratio. Antimicrobial screenings of the ligands and their complexes were conducted against gram-positive (Staphylococcus aureus,) and two gram-negative (Salmonella typhi, and Escherichia coli) bacteria specie. Also three fungi mainly (Candida albicans, Mucus indicus and Aspergillus flavus) were tested. The results showed that both the ligands and the complexes are active against the bacteria and the fungi specie. Keywords: Ligand, Schiff base, 4-phenylthiosemicarbazide, 2-acetylthiophene, 2-acetylfuran molar conductivity, magnetic susceptibility, elemental analysis.

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