scholarly journals Assessment of Phytochemical Constituents and Antimicrobial Activity of Lantana Camara L.

2017 ◽  
Vol 14 (3) ◽  
pp. 977-984
Author(s):  
Ajay Kumar ◽  
Shikha Singh ◽  
Pragati Saini
Keyword(s):  
Spectroscopic Analysis ◽  
Inhibitory Concentration ◽  
Positive Control ◽  
Lantana Camara ◽  
Proteus Vulgaris ◽  
Zone Of Inhibition ◽  
Phytochemical Compounds ◽  
Phytochemical Constituents ◽  
Microsporum Fulvum ◽  
Bacteria And Fungi

ABSTRACT: In present study the phytochemical constituents such as total phenol, total flavonoid contents and antibacterial activity against four gram negative and two gram positive isolates Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogens, Proteus vulgaris, Lactobacillus, S. aureus, Bacillus subtilis and antifungal activity against four fungal strains Penicillium, Aspergillus niger, T. mentagrophytes, Microsporum fulvum of petroleum ether, diethyl ether, chloroform and acetone extract of leaves and flowers of Lantana camara L were evaluated. Maximum zone of inhibition was recorded in the presence of free flavanoid fraction of the plant extract against Trichophyton mentagophytes and Microsporum fulvum which was the most susceptible fungus for all the extracts tested. The extract also compared favourably with streptomycin which serves as a positive control. Minimum inhibitory concentration (MIC) was recorded for all bacteria and fungi in which highest MIC was of B. subtilis and M. fulvum. The UV-Vis and FTIR spectroscopic analysis also revealed the presence of different active groups and bonds. L. camara contains phytochemical compounds with antibacterial & antifungal activities. Moreover, the chloroform & acetone leaf & flower extracts of L. camara are active against pathogenic microorganisms.

scholarly journals PHYTOCHEMICAL PROFILING AND ANTIBACTERIAL EFFICACY SCREENING OF AGLAIA MALABARICA SASIDH

2018 ◽  
Vol 10 (1) ◽  
pp. 20
Author(s):  
Archana Elamkulam Ravindran ◽  
John Ernest Thoppil
Keyword(s):  
Secondary Metabolites ◽  
Inhibitory Concentration ◽  
Forest Tree ◽  
Diffusion Method ◽  
Antibacterial Efficacy ◽  
Proteus Vulgaris ◽  
Disc Diffusion Method ◽  
Antibacterial Study ◽  
The Family ◽  
Phytochemical Constituents

Objective: Aglaia malabarica is an unexplored endemic forest tree belonging to the family Meliaceae. The present study was conducted to screen the phytochemical constituents of the leaf extract, to analyze the important secondary metabolites and to determine the antibacterial efficacy of the plant extract.Methods: Antibacterial activity was studied using agar based disc diffusion method. Four strains of bacteria were used for the antibacterial study that includes Staphylococcus aureus, Pseudomonas aeruginosae, Proteus vulgaris and Bacillus megaterium.Results: The presence of constituents like, carbohydrates, proteins, tannins, phenols, terpenoids, flavonoids, alkaloids and steroids were confirmed. Saponin was found to be absent. The secondary metabolites quantified were terpenoids, phenols and flavanoids, which were found in considerable amounts. The minimum inhibitory concentration (MIC) of all the bacteria studied was found to be 500 µg methanolic leaf extract.Conclusion: The plant extract was found to be highly potent against both the Gram positive and Gram negative strains and this property may be attributed to the potent phytochemicals revealed in the extract.

ANTIMICROBIAL ACTIVITY OF 3- (1- (3- HYDROXYPHENYL) AMINO) ETHYLIDENE) CHROMAN-2,4-DIONE AND ITS CORRESPONDING PALLADIUM(II) COMPLEX

2021 ◽  
Author(s):  
Edina Avdović ◽  
◽  
Žiko B. Milanović ◽  
Milanka Radulović ◽  
Dušan S. Dimić
Keyword(s):  
Antimicrobial Activity ◽  
Inhibitory Concentration ◽  
Antimicrobial Effect ◽  
Coumarin Derivative ◽  
The Other ◽  
Disc Diffusion ◽  
Zone Of Inhibition ◽  
Microdilution Method ◽  
Bacteria And Fungi

In this manuscript, the in vitro antimicrobial activity of the previously synthesized coumarin derivative 3- (1- (3-hydroxyphenyl) amino) ethylidene) chroman-2,4-dione (L) and its corresponding palladium (II) complex (C) were examined. Their antimicrobial activity was screened against four strains of bacteria Bacillus cereus (ATCC 11778) G+; Staphylococcus aureus (ATCC 13709) G+; Klebsiella pneumoniae (ATCC 27736) G-; and Escherichia coli (ATCC 2592) G-) and three strains of fungi (Aspergillus flavus (ATCC15517); Candida albicans (ATCC 10231); Fusarium oxysporum (ATCC 695) using disc diffusion and microdilution method. The obtained minimum inhibitory concentration (MIC) values by microdilution method for ligand and complex are similar for all tested bacteria and fungi, which means that both compounds have a similar antimicrobial effect. On the other hand, analysis of zone of inhibition (ZI) values for the tested compounds shows that the complex is generally somewhat more active than the ligand.

scholarly journals Griseococcin(1) from Bovistella radicata (Mont.) Pat and antimicrobial activity

2020 ◽  
Author(s):  
zeng qingmei ◽  
yong ye ◽  
Qinghua Zeng
Keyword(s):  
Antifungal Activity ◽  
Inhibitory Concentration ◽  
Fermentation Broth ◽  
Pathogenic Fungus ◽  
Deae Cellulose ◽  
Trichophyton Mentagrophytes ◽  
2D Nmr ◽  
Positive Control ◽  
Zone Of Inhibition ◽  
Ft Ir

Abstract Background: To evaluate the antifungal activity of B. radicata fermentation broth, the broth was purified by DEAE-cellulose and sephadex LC-20 column. The compounds were submitted to spectral analysises(HPLC, FT-IR, 1D and 2D NMR etc.). Results: The purified compounds were identified as the Griseococcin(s) which were naphthoquinone derivatives, only Griseococcin(1) has antifungal activity among the Griseococcin(s). Minimum inhibitory concentration(MIC) and zone of inhibition(ZOI) of Griseococcin(1) were 31.2, 31.2 μg/ml and 18.06±0.85 mm, 15.01±1.02 mm respectively against main pathogenic fungus Trichophyton rubrum and Trichophyton mentagrophytes, the Chemical formula and MW of Griseococcin(1) was determined as C37O10H43N and 661Da.Conclusions: In this paper, the secondary metabolite compound Griseococcin(1) from B. radicata was purified. The purified compound can restrain main pathogens(T. rubrum and T. mentagrophytes) leading to tinea pedis. The antifungal activity of Griseococcin(1) was similar to that of the positive control.

ANTIFUNGAL TOPICAL GEL OF LEAF EXTRACT OF AMARANTHUS VIRIDIS L. FOR TREATMENT OF CUTANEOUS CANDIDIASIS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (12) ◽  
pp. 39-44
Author(s):  
A. P. Pandit ◽  
◽  
K. S. Khandagale ◽  
V. C Nakhate ◽  
N. N Dharmadhikari
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Antifungal Activity ◽  
Leaf Extract ◽  
Inhibitory Concentration ◽  
High Viscosity ◽  
Good Choice ◽  
Zone Of Inhibition ◽  
Minimum Fungicidal Concentration ◽  
Topical Gel ◽  
Cutaneous Candidiasis

The objective of the study was to prepare antifungal gel using leaves of Amaranthus viridis for the treatment of cutaneous candidiasis. The leaves were studied for pharmacognostic evaluation. The powder of leaves was tested for phytoconstituents. The plant extract was evaluated for the minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and antifungal activity. Gel was prepared and evaluated for pH, viscosity, homogeneity and grittiness. MIC and MFC of extract were both found to be 600 mg. The zone of inhibition of extract was obtained at 21.2±0.2mm, which confirmed antifungal activity, due to presence of phenolic compound. Gel exhibited good antifungal activity, good spreadability, extrudability and high viscosity. Thus, gel loaded with leaves extract of A. viridis is a good choice for the treatment of cutaneous candidiasis.

scholarly journals DIFFERENCE BETWEEN ANTIMICROBIAL EFFECTS OF PAPACARIE AND PAPAIN ON STREPTOCOCCUS MUTANS IN VITRO

2019 ◽  
pp. 79-83
Author(s):  
TITTY SULIANTI ◽  
NILAKESUMA DJAUHARI ◽  
BAMBANG NURSASONGKO
Keyword(s):  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Zone Of Inhibition ◽  
Antimicrobial Effects ◽  
Treatment Groups ◽  
Group Control ◽  
Caries Removal ◽  
And Diffusion ◽  
Better Than

Objective: The aim is to compare the antimicrobial effects of papain and Papacarie with dilution and diffusion tests.Methods: There were two treatment groups and one Group control. The treatment group received papain and Papacarie, and the control groupreceived chlorhexidine, in five liquids with different concentrations of 0.5%, 0.25%, 0.125%, 0.0625%, and 0.03%. The dilution and diffusion testswere used to determine the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and zone of inhibition for eachtreatment material.Results: MICs of papain and Papacarie were 12.5%, indicating that at a concentration of 12.5%, the material can inhibit the growth of Streptococcusmutans. Papain does not have an MBC value but the Papacarie has an MBC at 25%, which indicating that at a concentration of 25%, Papacarie hasbactericidal effects on S. mutans. The zone of inhibition of papain was lower than Papacarie.Conclusion: Based on chemomechanical caries removal materials, the antimicrobial effects of Papacarie were better than those of papain.

scholarly journals Screening Of Antibacterial Activity Of Nepeta Ciliaris Benth. Against Respiratory Tract Pathogens

1970 ◽  
Vol 8 (1) ◽  
pp. 100-103 ◽  
Author(s):  
Gautam Shiv Shankar ◽  
M Navneet ◽  
Kumar Sanjay ◽  
M Prabhat
Keyword(s):  
Respiratory Tract ◽  
Antimicrobial Agents ◽  
Inhibitory Concentration ◽  
Methanol Extract ◽  
Bacterial Species ◽  
Positive Control ◽  
Maximum Activity ◽  
Diffusion Method ◽  
Aerial Parts ◽  
Antibacterial Potential

The aim of present study was to evaluate the antibacterial potential of various extracts (petroleum ether, acetone, methanol and aqueous) of Nepeta ciliaris against selected respiratory tract pathogens. The extracts from the aerial parts of N. ciliaris at concentration of 200 mg/ml were screened against three gram-positive (Staphylococcus aureus MTCC 1144, Streptococcus pneumoniae MTCC 655 and Streptococcus pyogenes MTCC 442) and one gram-negative (Pseudomonas aeruginosa MTCC 2474) bacterial pathogens. The agar well diffusion method was adopted to examine antibacterial and minimum inhibitory concentration (MIC) values of most effective extracts against the susceptible bacteria. Erythromycin was used as positive control to determine the sensitivity of the strains. Out of the four bacterial species tested, S. pneumoniae was the most susceptible. The acetone extract exhibited maximum activity against all the tested microorganisms while methanol extract showed activity against P. aeruginosa. The MIC values ranged from 40 to 50 mg/ml for all the organisms. The N. ciliaris is potentially a good source of antimicrobial agents. DOI: http://dx.doi.org/10.3126/kuset.v8i1.6049 KUSET 2012; 8(1): 100-103

scholarly journals Formulation and Evaluation of Antimicrobial Herbal Ointment

1970 ◽  
Vol 6 (1) ◽  
pp. 102-107 ◽  
Author(s):  
Himal Paudel Chhetri ◽  
Nisha Shrestha Yogol ◽  
Jyoti Sherchan ◽  
Anupa KC ◽  
S Mansoor ◽  
...  
Keyword(s):  
Inhibitory Concentration ◽  
Dosage Forms ◽  
Herbal Drugs ◽  
Zone Of Inhibition ◽  
Klebsiella Species ◽  
Effective Combination ◽  
Engineering And Technology ◽  
Ethanolic Extracts ◽  
Micro Organisms

Most of the antibiotics were originally derived from micro-organisms while thechemotherapeutic agents are from plants. Herbal medicine refers to the use of anyplant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. Alongwith other dosage forms, herbal drugs are also formulated in the form of ointment. Anointment is a viscous semisolid preparation used topically on a variety of bodysurfaces. The objective of the study was to formulate and evaluate the antimicrobialherbal ointment from the local medicinal plants. The ethanolic extracts of the selectedplants were taken in different ratio randomly and the antimicrobial tests of thecombinations were carried out. The most effective combination was then determinedby comparing the results of the zone of inhibition given by the 10 different extractratios on Staphylococcus aureus, Escherichia coli and Klebsiella species. Then theminimum inhibitory concentration of the effective combination was found out. Theointment base was prepared and formulation of ointment was done by incorporatingthe active ingredients in most effective ratio in the base by trituration. After thecompletion of the formulation, quality of the ointment was assessed in terms ofirritancy, spreadability, diffusion and stability.Key words: Herbal ointment; minimum inhibitory concentration; irritancy;spreadability; diffusion; stabilityDOI: 10.3126/kuset.v6i1.3317 Kathmandu University Journal of Science, Engineering and Technology Vol.6(1) 2010, pp102-107

scholarly journals Review Based Upon Ayurvedic and Traditional Uses of Cinnamomum tamala (Tejpatta)

2021 ◽  
Vol 68 (2) ◽  
Author(s):  
Shifali Thakur ◽  
Gitika Chaudhary
Keyword(s):  
Chemical Constituents ◽  
Bioactive Constituents ◽  
Pharmacological Activities ◽  
The Past ◽  
Cinnamomum Tamala ◽  
Medicinal Use ◽  
Phytochemical Compounds ◽  
Phytochemical Constituents ◽  
Herbal Plant ◽  
Flavoring Agent

Cinnamomum tamala is an evergreen plant native to Sri Lanka and India. This herbal plant is commonly called Indian cassia, Tejpatta and Indian bay leaf. There are many bioactive constituents isolated from plant Cinnamomum tamala. Leaves of the plant possess aromatic fragrance and are also utilized as a flavoring agent. It is used in food curry, pickles and other spices. Besides food application, the leaves have also been used for curing a number of ailments. All parts of the plant possess many major bioactive chemical constituents like cinnamaldehyde, trans-cinnamaldehyde, 3,4,5,7- tetrahydroxyflavone, 3,3,4,5,6- pentahydroflavone (non-glycoside compounds), kaempferol, eugenol, etc. These phytochemical compounds have many pharmacological activities such as anticancer, antidiabetic, antimicrobial, hepatoprotective, antidiarrheal and immunomodulatory. In the past time, it is also considered for medicinal use. Their medicinal use was also mentioned in the literature of ayurveda, yunani and other traditional systems of medicine. Due to aromatic fragrance, it is also utilized in the perfume industry. The major aim of this review is to give a brief knowledge about the plant Cinnamomum tamala based on their phytochemical constituents, ayurvedic view, folk view and pharmacological application.

scholarly journals ANTIBACTERIAL ACTIVITY OF METHANOLIC RHIZOME EXTRACT OF ALPINIA CALCARATA ROSC. (ZINGIBERACEAE)

2016 ◽  
Vol 3 (1) ◽  
pp. 65-66
Author(s):  
Arumugasamy K ◽  
Nantha Kumar R ◽  
Abdul Kaffoor H ◽  
Shalimol A
Keyword(s):  
Antibacterial Activity ◽  
Bacterial Species ◽  
Antibacterial Activities ◽  
Bacterial Activity ◽  
Proteus Vulgaris ◽  
Bacterial Strains ◽  
Zone Of Inhibition

The methanolic rhizome extract of A. calcarata was evaluated for its antibacterial activities against five bacterial strains Pseudomonas aeuroginosa, Proteus vulgaris, Salmonella paratyphi, Bacillus thurungiensis and Staphylococcus faccealis. The extract has inhibited all the tested bacterial species with different manner at various concentration. However the higher level zone of inhibition in 400 (mg/ml) is significant against all the above said bacterial strains of these Salmonella paratyphi. Based on the present study it can be conculuded that the plant rhizome possess potent anti bacterial activity.

scholarly journals Synthesis, Molecular Docking and Antimicrobial Evaluation of Some Benzothiazoles

2021 ◽  
Author(s):  
Smita J. Pawar ◽  
Amol Kale ◽  
Priya Zori ◽  
Rahul Dorugade
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Property ◽  
Docking Study ◽  
Gram Negative Bacteria ◽  
Zone Of Inhibition ◽  
E Coli ◽  
Good Antibacterial Activity ◽  
Comparable Activity ◽  
Antimicrobial Evaluation ◽  
Bacteria And Fungi

Abstract Abstract The new series of 2-(substituted amino)-N-(6- substituted-1,3-benzothiazol-2yl) acetamide BTC(a-t) has been synthesized by appropriate synthetic route from substituted 2-amino benzothiazole. The synthesized compounds were screened experimentally for its antimicrobial property against gram positive, gram negative bacteria and fungi. Zone of inhibition and minimum inhibitory concentration of compounds was determined against selected bacterial and fungal strains. Compound BTC-j N-(6-methoxy-1,3-benzothiazol-2-yl)-2-(pyridine-3-yl amino) acetamide and compound BTC-r N-(6-nitro-1,3-benzothiazol-2-yl)-2-(pyridine-3-yl amino) acetamide found to have good antimicrobial potential. The compound BTC-j has shown good antibacterial activity against S. aureus at MIC of 12.5 µg/ml, B. subtilis at MIC of 6.25µg/ml, E. coli at MIC of 3.125µg/ml and P. aeruginosa at MIC of 6.25µg/ml. No statistical difference in antimicrobial activity of standard and test compounds was found indicating test compounds have comparable activity. Further docking study was carried out to check the probable interactions with the selected protein using V-life MDS 3.5 software. (DNA gyrase, PDB: 3G75). The dock score of compounds and antimicrobial activity found to be consistent.

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