scholarly journals Effect of a Dipeptide-Enriched Diet in an Adult Drosophila melanogaster Laboratory Strain

2013 ◽  
Vol 77 (4) ◽  
pp. 836-838 ◽  
Author(s):  
Shigenobu SHIOTANI ◽  
Nobuya YANAI ◽  
Takanori SUZUKI ◽  
Shiho TUJIOKA ◽  
Yurie SAKANO ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Laboratory Strain ◽  
Adult Drosophila

Towards a Drosophila model of Hutchinson–Gilford progeria syndrome

2008 ◽  
Vol 36 (6) ◽  
pp. 1389-1392 ◽  
Author(s):  
Gemma S. Beard ◽  
Joanna M. Bridger ◽  
Ian R. Kill ◽  
David R.P. Tree
Keyword(s):  
Drosophila Melanogaster ◽  
Premature Aging ◽  
Lamin A ◽  
Wild Type ◽  
Drosophila Model ◽  
Numerous Cell ◽  
Cellular Abnormalities ◽  
Progeria Syndrome ◽  
Hutchinson Gilford Progeria Syndrome ◽  
Adult Drosophila

The laminopathy Hutchinson–Gilford progeria syndrome (HGPS) is caused by the mutant lamin A protein progerin and leads to premature aging of affected children. Despite numerous cell biological and biochemical insights into the basis for the cellular abnormalities seen in HGPS, the mechanism linking progerin to the organismal phenotype is not fully understood. To begin to address the mechanism behind HGPS using Drosophila melanogaster, we have ectopically expressed progerin and lamin A. We found that ectopic progerin and lamin A phenocopy several effects of laminopathies in developing and adult Drosophila, but that progerin causes a stronger phenotype than wild-type lamin A.

scholarly journals THE EFFECTS OF HETEROZYGOSITY CHANGES ON VIABILITY IN DROSOPHILA MELANOGASTER

Genetics ◽  
1972 ◽  
Vol 70 (4) ◽  
pp. 595-610
Author(s):  
Ray Moree
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Background ◽  
Laboratory Strain ◽  
Theoretical Expectation ◽  
Wild Type ◽  
Small Deviations ◽  
The Third ◽  
The Difference

ABSTRACT The viability effects of chromosomes from an old and from a new laboratory strain of D. melanogaster were studied in eight factorial combinations and at two heterozygosity levels. The combinations were so constructed that heterozygosity level could be varied in the third chromosomes of the carriers of a homozygous lethal marker, in the third chromosomes of their wild-type segregants, and in the genetic backgrounds of both. Excluding the effect of the marker and the exceptional outcomes of two of the combinations, and taking into account both large and small deviations from theoretical expectation, the following summary is given as the simplest consistent explanation of the results: 1) If total heterozygosities of two segregant types tend toward equality their viabilities tend toward equality also, whether background heterozygosity is high or low; if background heterozygosities is higher the tendency toward equality is slightly greater. 2) If total heterozygosity of two segregant types are unequal the less heterozygous type has the lower viability; the difference is more pronounced when background heterozygosity is low, less when it is high. 3) Differences between segregant viabilities are correlated with differences between the total heterozygosities of the two segregants; genetic background is effective to the extent, and only to the extent, that it contributes to the magnitude of this difference. This in turn appears to underlie, at least partly, the expression of a pronounced interchromosomal epistasis. Thus in this study viability is seen to depend upon both the quantity and distribution of heterozygosity, not only among the chromosomes of an individual but among the individuals of a given combination as well.

The Transplantation of Ovaries between Genetically Sterile and Wild Type Drosophila melanogaste

1965 ◽  
Vol 20 (4) ◽  
pp. 292-297 ◽  
Author(s):  
Robert C. King ◽  
Dietrich Bodenstein
Keyword(s):  
Drosophila Melanogaster ◽  
Body Cavity ◽  
Ovarian Tumors ◽  
Wild Type ◽  
Adult Females ◽  
Recessive Genes ◽  
Initiating Factors ◽  
Adult Drosophila ◽  
Do So ◽  
Drosophila Melanogaste

Ovarian tumors are characteristically found in adult Drosophila melanogaster females homozygous for certain recessive genes (fes, nw and fu). Ovaries genetically destined to become tumorous do so even when they are transplanted to a normal abdomen. Normal ovaries transplanted to the abdomen of females homozygous for such tumor genes do not become tumorous. Therefore there is no evidence for diffusible tumorigenic agents as initiating factors in the development of the ovarian tumors characteristic of females homozygous for fes, nw or fu. Vitellogenesis is retarded in adult females homozygous for certain recessive genes (fs 2.1, ty and ap4). Transplantation of ovaries from homozygous females to the abdominal body cavity of females carrying the + alleles of the gene in question fails to cure the implant in the case of fs 2.1 and ty. Ovaries of ap4/ap4 genotype produce abundant yolk when implanted into wild type abdomens. Thus it is the abdominal environment of ap4 which is at fault, rather than a malfunctioning of the ovary.

scholarly journals Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span

2005 ◽  
Vol 15 (22) ◽  
pp. 2063-2068 ◽  
Author(s):  
Johannes H. Bauer ◽  
Peter C. Poon ◽  
Heather Glatt-Deeley ◽  
John M. Abrams ◽  
Stephen L. Helfand
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Dominant Negative ◽  
Neuronal Expression ◽  
Adult Drosophila

The Effects of Age on Radiation Resistance and Oxidative Stress in Adult Drosophila melanogaster

2008 ◽  
Vol 169 (6) ◽  
pp. 707-711 ◽  
Author(s):  
Vijay Parashar ◽  
Stewart Frankel ◽  
Alan G. Lurie ◽  
Blanka Rogina
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Radiation Resistance ◽  
And Oxidative Stress ◽  
Adult Drosophila

EFFECTS OF INGESTED ETHANOL ON ADULT DROSOPHILA MELANOGASTER (DIPTERA: DROSOPHILIDAE)

1981 ◽  
Vol 113 (4) ◽  
pp. 315-323 ◽  
Author(s):  
S. S. Chawla ◽  
J.-M. Perron ◽  
C. Radouco-Thomas
Keyword(s):  
Drosophila Melanogaster ◽  
Experimental Conditions ◽  
Water Solutions ◽  
Sucrose Solutions ◽  
Adult Drosophila ◽  
Better Than

AbstractAn apparatus consisting of a plastic box and a feeding circuit permits the calculation of μl volumes of ethanol ingested by Drosophila melanogaster Meigen. The net amount of ethanol taken (expressed in 100% ethanol) has been examined in various experimental conditions: sucrose solutions, ethanol–sucrose solutions at various sucrose and alcohol concentrations, ethanol solutions - cube of sucrose and ethanol solutions alone. The data obtained on ingestion by Drosophila show that the consumption of sucrose solutions was inversely proportional to the concentrations of sucrose. The amount of ethanol ingested during 14 days was directly related to the concentration of ethanol in the diets although in general the total volume of solution consumed did not vary significantly in most cases. The analyses of observations of 14 days showed that decreased mortality was obtained with the rise in the concentration of sucrose in sucrose-water solutions in 0.5–3% range and the mortality increased with the rise in the concentration of ethanol in the diets, yet ethanol-sucrose was better than cube of sugar alone.

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