The Effects of Age on Radiation Resistance and Oxidative Stress in Adult Drosophila melanogaster

2008 ◽  
Vol 169 (6) ◽  
pp. 707-711 ◽  
Author(s):  
Vijay Parashar ◽  
Stewart Frankel ◽  
Alan G. Lurie ◽  
Blanka Rogina
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Radiation Resistance ◽  
And Oxidative Stress ◽  
Adult Drosophila

The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster

2006 ◽  
Vol 127 (4) ◽  
pp. 356-370 ◽  
Author(s):  
Tapiwanashe Magwere ◽  
Melanie West ◽  
Kumars Riyahi ◽  
Michael P. Murphy ◽  
Robin A.J. Smith ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Stress Resistance ◽  
Oxidative Stress Resistance ◽  
And Oxidative Stress

scholarly journals Posthypoxic behavioral impairment and mortality of Drosophila melanogaster are associated with high temperatures, enhanced predeath activity and oxidative stress

2021 ◽  
Author(s):  
Pardes Habib ◽  
Jennifer Jung ◽  
Gina Maria Wilms ◽  
Alma Kokott-Vuong ◽  
Shahin Habib ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Metabolic Activity ◽  
Environmental Conditions ◽  
Severe Hypoxia ◽  
Oxidative Stress Marker ◽  
Early Reperfusion ◽  
Stress Marker ◽  
And Oxidative Stress ◽  
Reperfusion Phase

AbstractHypoxia is an underlying pathophysiological condition of a variety of devastating diseases, including acute ischemic stroke (AIS). We are faced with limited therapeutic options for AIS patients, and even after successful restoration of cerebral blood flow, the poststroke mortality is still high. More basic research is needed to explain mortality after reperfusion and to develop adjunct neuroprotective therapies. Drosophila melanogaster (D.m.) is a suitable model to analyze hypoxia; however, little is known about the impacts of hypoxia and especially of the subsequent reperfusion injury on the behavior and survival of D.m. To address this knowledge gap, we subjected two wild-type D.m. strains (Canton-S and Oregon-R) to severe hypoxia (<0.3% O2) under standardized environmental conditions in a well-constructed hypoxia chamber. During posthypoxic reperfusion (21% O2), we assessed fly activity (evoked and spontaneous) and analyzed molecular characteristics (oxidative stress marker abundance, reactive oxygen species (ROS) production, and metabolic activity) at various timepoints during reperfusion. First, we established standard conditions to induce hypoxia in D.m. to guarantee stable and reproducible experiments. Exposure to severe hypoxia under defined conditions impaired the climbing ability and reduced the overall activity of both D.m. strains. Furthermore, a majority of the flies died during the early reperfusion phase (up to 24 h). Interestingly, the flies that died early exhibited elevated activity before death compared to that of the flies that survived the entire reperfusion period. Additionally, we detected increases in ROS and stress marker (Catalase, Superoxide Dismutase and Heat Shock Protein 70) levels as well as reductions in metabolic activity in the reperfusion phase. Finally, we found that changes in environmental conditions impacted the mortality rate. In particular, decreasing the temperature during hypoxia or the reperfusion phase displayed a protective effect. In conclusion, our data suggest that reperfusion-dependent death might be associated with elevated temperatures, predeath activity, and oxidative stress.

scholarly journals EXPRESSION PROFILE OF AGING AND OXIDATIVE STRESS RESPONSE IN DROSOPHILA MELANOGASTER

2001 ◽  
Vol 1 (S3) ◽  
pp. 138-138
Author(s):  
Sige Zou ◽  
Sarah Meadows ◽  
Linda Sharp ◽  
Lily Y. Jan ◽  
Yuh Nung Jan
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Stress Response ◽  
Expression Profile ◽  
Oxidative Stress Response ◽  
And Oxidative Stress
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