scholarly journals Nitric Oxide Donating Compounds Inhibit HCl-Induced Gastric Mucosal Lesions Mainly via Prostaglandin

2001 ◽  
Vol 85 (2) ◽  
pp. 133-138 ◽  
Author(s):  
Masayuki Uchida ◽  
Kei Matsueda ◽  
Ryosuke Shoda ◽  
Akira Muraoka ◽  
Shigeru Yamato
Keyword(s):  
Nitric Oxide ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Effect of nitric oxide on gastric mucosal lesions induced by water-immersion-restraint stress

2000 ◽  
Vol 118 (4) ◽  
pp. A1244
Author(s):  
Hiroshi Hashimoto ◽  
Akiko Yanagisawa ◽  
Masumi Akimoto ◽  
Mutsuo Shigemoto ◽  
Katsuko Yamashita
Keyword(s):  
Nitric Oxide ◽  
Restraint Stress ◽  
Water Immersion ◽  
Gastric Mucosal Lesions ◽  
Water Immersion Restraint Stress ◽  
Mucosal Lesions

scholarly journals Protective Effects of Wheat Peptides against Ethanol-Induced Gastric Mucosal Lesions in Rats: Vasodilation and Anti-Inflammation

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2355
Author(s):  
Lanlan Yu ◽  
Ruijun Li ◽  
Wei Liu ◽  
Yalin Zhou ◽  
Yong Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Mucosal Injury ◽  
Ethanol Administration ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Gastric Mucosal Lesions ◽  
Signaling Transduction Pathway ◽  
Mucosal Lesions

Alcohol consumption increases the risk of gastritis and gastric ulcer. Nutritional alternatives are considered for relieving the progression of gastric mucosal lesions instead of conventional drugs that produce side effects. This study was designed to evaluate the gastroprotective effects and investigate the defensive mechanisms of wheat peptides against ethanol-induced acute gastric mucosal injury in rats. Sixty male Sprague–Dawley rats were divided into six groups and orally treated with wheat peptides (0.1, 0.2, 0.4 g/kgbw) and omeprazole (20 mg/kgbw) for 4 weeks, following absolute ethanol administration for 1 h. Pretreatment with wheat peptides obviously enhanced the vasodilation of gastric mucosal blood vessels via improving the gastric mucosal blood flow and elevating the defensive factors nitric oxide (NO) and prostaglandin E2 (PGE2), and lowering the level of vasoconstrictor factor endothelin (ET)-1. Wheat peptides exhibited anti-inflammatory reaction through decreasing inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, and increasing trefoil factor 1 (TFF1) levels. Moreover, wheat peptides significantly down-regulated the expression of phosphorylated nuclear factor kappa-B (p-NF-κB) p65 proteins in the NF-κB signaling pathway. Altogether, wheat peptides protect gastric mucosa from ethanol-induced lesions in rats via improving the gastric microcirculation and inhibiting inflammation mediated by the NF-κB signaling transduction pathway.

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