scholarly journals Irsogladine Prevents Monochloramine-Induced Gastric Mucosal Lesions by Improving the Decrease in Mucosal Blood Flow Due to the Disturbance of Nitric Oxide Synthesis in Rats

2003 ◽  
Vol 93 (3) ◽  
pp. 314-320 ◽  
Author(s):  
Takashi Kyoi ◽  
Michiko Oka ◽  
Kumiko Noda ◽  
Yojiro Ukai
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Nitric Oxide Synthesis ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Protective Effects of Wheat Peptides against Ethanol-Induced Gastric Mucosal Lesions in Rats: Vasodilation and Anti-Inflammation

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2355
Author(s):  
Lanlan Yu ◽  
Ruijun Li ◽  
Wei Liu ◽  
Yalin Zhou ◽  
Yong Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Mucosal Injury ◽  
Ethanol Administration ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Gastric Mucosal Lesions ◽  
Signaling Transduction Pathway ◽  
Mucosal Lesions

Alcohol consumption increases the risk of gastritis and gastric ulcer. Nutritional alternatives are considered for relieving the progression of gastric mucosal lesions instead of conventional drugs that produce side effects. This study was designed to evaluate the gastroprotective effects and investigate the defensive mechanisms of wheat peptides against ethanol-induced acute gastric mucosal injury in rats. Sixty male Sprague–Dawley rats were divided into six groups and orally treated with wheat peptides (0.1, 0.2, 0.4 g/kgbw) and omeprazole (20 mg/kgbw) for 4 weeks, following absolute ethanol administration for 1 h. Pretreatment with wheat peptides obviously enhanced the vasodilation of gastric mucosal blood vessels via improving the gastric mucosal blood flow and elevating the defensive factors nitric oxide (NO) and prostaglandin E2 (PGE2), and lowering the level of vasoconstrictor factor endothelin (ET)-1. Wheat peptides exhibited anti-inflammatory reaction through decreasing inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, and increasing trefoil factor 1 (TFF1) levels. Moreover, wheat peptides significantly down-regulated the expression of phosphorylated nuclear factor kappa-B (p-NF-κB) p65 proteins in the NF-κB signaling pathway. Altogether, wheat peptides protect gastric mucosa from ethanol-induced lesions in rats via improving the gastric microcirculation and inhibiting inflammation mediated by the NF-κB signaling transduction pathway.

Cholecystokinin secretagogue-induced gastroprotection: role of nitric oxide and blood flow

2003 ◽  
Vol 284 (3) ◽  
pp. G399-G410 ◽  
Author(s):  
Sonlee D. West ◽  
Kenneth S. Helmer ◽  
Lily K. Chang ◽  
Yan Cui ◽  
George H. Greeley ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Gastric Injury ◽  
Protective Mechanism ◽  
Adaptive Cytoprotection ◽  
Mucosal Defense ◽  
Calcium Dependent

This study was done to examine the role of CCK in gastric mucosal defense and to assess the gastroprotective roles of nitric oxide and blood flow. In rats, the CCK secretagogues oleate and soybean trypsin inhibitor augmented gastric mucosal blood flow and prevented gastric injury from luminal irritants. Type A CCK receptor blockade negated CCK secretagogue-induced gastroprotection and exacerbated gastric injury from bile and ethanol but did not block adaptive cytoprotection. CCK secretagogue-induced gastroprotection and hyperemia were negated by nonselective nitric oxide synthase (NOS) inhibition ( N G-nitro-l-arginine methyl ester) but not by selective inducible NOS inhibition (aminoguanidine). Gastric mucosal calcium-dependent NOS activity, but not calcium-independent NOS activity, was increased following CCK and CCK secretagogues. The release of endogenous CCK plays a role in the intrinsic gastric mucosal defense system against injury from luminal irritants. The protective mechanism appears to involve increased production of nitric oxide from primarily the constitutive isoforms of NOS and a resultant increase in blood flow.

Enhanced Nitric Oxide Synthesis Reverses Salt-Induced Alterations in Blood Flow and Cgmp Levels

1999 ◽  
Vol 21 (4) ◽  
pp. 333-352 ◽  
Author(s):  
M. A. Bayorh ◽  
E. Williams ◽  
M. Thierry-Palmer ◽  
G. Sanford ◽  
N. Emmett ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Nitric Oxide Synthesis

scholarly journals Systemic Hemodynamics and Regional Blood Flow During Chronic Nitric Oxide Synthesis Inhibition in Pregnant Rats

Hypertension ◽  
1998 ◽  
Vol 31 (1) ◽  
pp. 315-320 ◽  
Author(s):  
Salah Kassab ◽  
M. Todd Miller ◽  
Robert Hester ◽  
Jacqueline Novak ◽  
Joey P. Granger
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Regional Blood Flow ◽  
Systemic Hemodynamics ◽  
Nitric Oxide Synthesis ◽  
Pregnant Rats ◽  
Synthesis Inhibition

Role of Nitric Oxide in Mucosal Blood Flow Response and the Healing of HCI-lnduced Lesions in the Rat Stomach

Digestion ◽  
1997 ◽  
Vol 58 (1) ◽  
pp. 19-27 ◽  
Author(s):  
K. Takeuchi ◽  
S. Kato ◽  
K. Takehara ◽  
Y. Asada ◽  
T. Yasuhiro
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Mucosal Blood Flow ◽  
Rat Stomach ◽  
Blood Flow Response ◽  
Flow Response
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