scholarly journals Antiinflammatory and Antioxidant Effects of Aqueous Extract from Phellinus gilvus in Rats

2011 ◽  
Vol 57 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Sung-Hwan Kim ◽  
Jeong-Hyeon Lim ◽  
Changjong Moon ◽  
Soo-Hyun Park ◽  
Sung-Ho Kim ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Antioxidant Effects ◽  
Phellinus Gilvus

Antioxidant Effects of Aqueous Extract of Sweet Potato and Ascorbic Acid on Paracetamol Induced Damage

2005 ◽  
Vol 6 (1) ◽  
pp. 87-92
Author(s):  
A.O. Lawal . ◽  
A. Ologundudu . ◽  
F.O. Obi . ◽  
I.V. Ogungbe . ◽  
A.O. Olakanye . ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Sweet Potato ◽  
Aqueous Extract ◽  
Antioxidant Effects

scholarly journals Evaluation of the antitumor and antioxidant effects of jatobá (Hymenaea courbaril) extracts / Avaliação do efeito antitumoral e antioxidante de extratos do jatobá (Hymenaea courbaril)

2021 ◽  
Vol 7 (12) ◽  
pp. 116001-116018
Author(s):  
Elisângela Miranda de Jesus Lisboa ◽  
Lucinéia Reuse Albiero ◽  
Nadila Melchiors ◽  
Wesley Sandro de Paula Borges ◽  
Valfran da Silva Lima ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Reduced Glutathione ◽  
Tumor Development ◽  
Thiobarbituric Acid ◽  
Renal Tissue ◽  
Ehrlich Carcinoma ◽  
Thiobarbituric Acid Reactive Substances ◽  
Hymenaea Courbaril ◽  
Antioxidant Effects

Ethnobotanical surveys have revealed the use of jatobá for the treatment of several diseases. This study determined the effect of plant extracts on the development of Ehrlich carcinoma. Male Swiss mice (n=6) were subcutaneously inoculated with 106 tumor cells and intragastrically administered ethanol (2 mg·mL-1, 5 mg·mL-1, or 10 mg·mL-1) or aqueous extracts of jatobá seed or bark for 90 days. Tumor development did not significantly differ between the groups studied; however, animals treated with the aqueous extract of the seed (2.205 mg·mL-1) had a reduction in tumor size compared to those treated with the aqueous extract of the bark (1.7 mg·mL-1). The treatment was not found to influence the survival of the animals studied. A new group of animals (n=7), with or without the tumor, received the aqueous extract of jatobá seed for 7, 14, and 30 days to evaluate oxidative stress. The extract reduced the thiobarbituric acid reactive substances levels at 7 days in the liver and kidneys, and 14 days in brain and renal tissue. Protein carbonylation levels were also reduced at 7 days in the liver and brain tissue and 14 days in the liver. The reduced glutathione levels diminished in animals treated for 7 and 14 days. We conclude that treatment with the aqueous extract of the jatobá seed presents promising activity in the reduction of oxidative stress.

Antihyperglycemic Effect of the Aqueous Extract of Foeniculum vulgare in Normal and Streptozotocin-induced Diabetic Rats

2020 ◽  
Vol 20 (1) ◽  
pp. 54-63
Author(s):  
Fadwa El-Ouady ◽  
Nadia Lahrach ◽  
Mohammed Ajebli ◽  
Ahmed E. Haidani ◽  
Mohamed Eddouks
Keyword(s):  
Blood Glucose ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Oral Glucose ◽  
Foeniculum Vulgare ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Antioxidant Effects

Background: Diabetes mellitus is associated with high blood glucose levels due to insulin shortcoming (insulinopenia) or defective insulin action. The objective of the study was to investigate the antidiabetic and antioxidant effects of Foeniculum vulgare in streptozotocin-induced diabetic rat. Methods: The effects of the leaves aqueous extract (LAE) of Foeniculum vulgare (F. vulgare) at a dose of 10 mg/kg on blood glucose levels were evaluated in normal and streptozotocin (STZ)- induced diabetic rats. Histopathological changes were also evaluated in liver in STZ-induced rats. Results: Single oral administration of F. vulgare LAE reduced blood glucose levels 6 h after administration in STZ diabetic rats (p<0.0001). Furthermore, blood glucose levels were decreased in both normal (p<0.05) and STZ diabetic rats (p<0.0001) after the fifteenth day of treatment. During this test, both groups did not show any significant change in their body weight. Moreover, this aqueous extract improved oral glucose tolerance in diabetic rats and revealed a positive effect on liver histology. On the other hand, the extract used in this experiment showed an inhibitory concentration (IC50) of 50% of free radicals with a concentration of 43±1.19 µg/ml. While the synthetic antioxidant (BHT) had an IC50 equal to 22.67±2.17µg /ml. Conclusion: This study demonstrates the antihyperglycemic, hypoglycemic and antioxidant effects of the leaves of F. vulgare in normal and diabetic rats.

Antihyperglycemic potential of Matricaria pubescens(Desf.) Schultz. in streptozotocin-induced diabetic rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Ayoub Amssayef ◽  
Mohammed Ajebli ◽  
Mohamed Eddouks
Keyword(s):  
Aqueous Extract ◽  
Aerial Part ◽  
Histopathological Examination ◽  
Diabetic Rats ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Liver And Pancreas ◽  
Treatment Of Diabetes ◽  
Antioxidant Effects

Aims: The aim of the study was to investigate the antihyperglycemic activity of Matricaria pubescens. Background: Matricaria pubescens (Def). Shultz (Asteraceae) is commonly used traditionally for the treatment of diabetes in Morocco. Objective: This present investigation aimed to assess the antihyperglycemic and antioxidant effects of the aqueous extract of aerial part of Matricaria pubescens (M. pubescens). Methods: The effect of a single and repeated oral administration of the aqueous extract of aerial part of M. pubescens (AEAPMP) at a dose of 40 mg/kg on glucose was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of pancreas and liver was carried out according to the Hematoxylin-Eosin method. The antioxidant activity was performed using the DPPH assay. Results: The results showed that the aqueous extract of M. pubescens (AEAPMP) exhibited a significant lowering activity on blood glucose levels in STZ-induced diabetic rats. In addition, AEAPMP ameliorated the histopathological tissues of liver and pancreas. Furthermore, a potential in vitro antioxidant of AEAPMP has been shown. Conclusion: In conclusion, this study demonstrates that M. pubescens possesses a beneficial effect against hyperglycemia associated with diabetes.

scholarly journals Antioxidant Effects of Barley Aqueous Extract on the Oxidative Deterioration of Oil.

1997 ◽  
Vol 44 (11) ◽  
pp. 788-794 ◽  
Author(s):  
Goro KAJIMOTO ◽  
Maki YAMAGUCHI ◽  
Takanori KUSANO ◽  
Kiyoshi GODA ◽  
Junichiro YAMAMOTO ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Oxidative Deterioration ◽  
Antioxidant Effects

scholarly journals Anticlastogenic potential and antioxidant effects of an aqueous extract of pulp from the pequi tree (Caryocar brasiliense Camb)

2007 ◽  
Vol 30 (2) ◽  
pp. 442-448 ◽  
Author(s):  
Juliana Khouri ◽  
Inês S. Resck ◽  
Marcio Poças-Fonseca ◽  
Thiago M.M. Sousa ◽  
Luciana O. Pereira ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Caryocar Brasiliense ◽  
Antioxidant Effects

Antioxidant Effects of an Aqueous Extract of Ilex paraguariensis

2000 ◽  
Vol 269 (2) ◽  
pp. 357-360 ◽  
Author(s):  
G.R. Schinella ◽  
G. Troiani ◽  
V. Dávila ◽  
P.M. de Buschiazzo ◽  
H.A. Tournier
Keyword(s):  
Aqueous Extract ◽  
Ilex Paraguariensis ◽  
Antioxidant Effects

scholarly journals Estrogenic and Antioxidant Activities of Pterocarpus soyauxii (Fabaceae) Heartwood Aqueous Extract in Bilateral Oophorectomized Wistar Rat

2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Yolande Sandrine Mengue Ngadena ◽  
Pascal Emmanuel Owona ◽  
Michel Noubom ◽  
Michel Arnaud Mbock ◽  
Lohik MbolangNguegan ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Aqueous Extract ◽  
Antioxidant Activities ◽  
Wistar Rat ◽  
Control Group ◽  
Postmenopausal Symptoms ◽  
Ovx Rats ◽  
Ethylhexyl Phthalate ◽  
Antioxidant Effects

Phytoestrogens are used to ease postmenopausal symptoms, a property probably due to estrogenic and antioxidant effects. Pterocarpus soyauxii (P. soyauxii) is empirically used in Cameroon to treat among others primary and secondary amenorrhea. The aim of this study is to evaluate estrogenic and antioxidant activities of P. soyauxii heartwood aqueous extract in bilateral oophorectomized Wistar rats. Firstly, a characterization of the extract was carried out. For that, flavonoids, phenols, and tannins levels in P. soyauxii extract were evaluated by colorimetric assays and UHPLC-MS analysis was realized. In vitro antioxidant analysis of P. soyauxii was conducted using DPPH, ABTS, and FRAP assays. Secondly, 2 sets of pharmacologic tests were carried out. The results revealed that P. soyauxii aqueous extract contains, respectively, 229.42 ± 3.62 mg EAG/g, 63.42 ± 2.16 mg EQ/g, and 27.88 ± 0.23 mg ETA/g of polyphenols, flavonoids, and tannins. UHPLC-MS enabled identifying seven components including mono(2-ethylhexyl) phthalate, cembrene, 3′,5′-dimethoxy-4-stilbenol, and linoleic acid. DPPH, ABTS, and FRAP assays revealed that P. soyauxii extract possessed a high antioxidant activity with IC50 value of 730.20 µg/mL, 892.90 µg/mL, and 765.75 mEAG/g of extract, respectively. In the uterotrophic assay, P. soyauxii extract induced significant increase of fresh uterine weight, uterine and vaginal epithelial size, and mammary glands differentiation compared to Ovx control. In the postmenopausal model, compared to the sham control, vagina and uterine dystrophies were observed in Ovx rats treated with distilled water. P. soyauxii aqueous extract expressed estrogenic-like effects on vagina and did not affect uterine epithelial height compared with vehicle groups. On the back of these vaginotrophic effects, the extract displayed antiatherogenic properties by reducing ( p  < 0.001) AI and LDL cholesterol level as compared to Ovx control group. The extract at 200 mg/kg significantly prevented the increase of MDA ( p  < 0.01) level and decreased nitrites ( p  < 0.001) and GSH ( p  < 0.01) levels compared to Ovx rats. These beneficial effects are related at least in part to the presence of compound such as mono(2-ethylhexyl) phthalate, 3′,5′-dimethoxy-4-stilbenol, and linoleic acid. Overall, P. soyauxii aqueous extract exhibits estrogenic and antioxidant effects which can inhibit postmenopausal symptoms by providing vaginal stratification, improving lipid profile and insulin sensitivity, and reducing oxidative stress without side effects on the endometrium and mammary gland in 84-day Ovx rats.

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