scholarly journals Studies on pharmacological activation of human serum IgG by chemical modification and active subfragments. II. Inhibitory effects of carboxamidemethylated L chain from human serum IgG on various ulcer models and its inhibition mechanism.

1983 ◽  
Vol 6 (7) ◽  
pp. 449-458
Author(s):  
TSUTOMU MIMURA ◽  
MASAKAZU IWAI ◽  
TAICHIRO TERADA ◽  
ISAO KOHDA ◽  
KAZUTAKE TSUJIKAWA ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Human Serum ◽  
Inhibition Mechanism ◽  
Inhibitory Effects ◽  
Serum Igg

Structural Analysis of an N-Glycan with “β1−4 Bisecting Branch” from Human Serum IgG by Negative-Ion MSnSpectral Matching and Exoglycosidase Digestion

2005 ◽  
Vol 77 (18) ◽  
pp. 6062-6068 ◽  
Author(s):  
Yasuhiro Takegawa ◽  
Kisaburo Deguchi ◽  
Hiroaki Nakagawa ◽  
Shin-Ichiro Nishimura
Keyword(s):  
Structural Analysis ◽  
Human Serum ◽  
Negative Ion ◽  
Serum Igg

scholarly journals Selective Inhibition of Bakuchicin Isolated fromPsoralea corylifoliaon CYP1A in Human Liver Microsomes

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sun Joo Kim ◽  
Heung Chan Oh ◽  
Youn-Chul Kim ◽  
Gil-Saeng Jeong ◽  
Sangkyu Lee
Keyword(s):  
Human Liver ◽  
Competitive Inhibition ◽  
Biological Activities ◽  
Biological Effects ◽  
Liver Microsomes ◽  
Selective Inhibition ◽  
Human Liver Microsomes ◽  
Inhibition Mechanism ◽  
Inhibitory Effects ◽  
Cyp Isoforms

Bakuchicin is a furanocoumarin isolated fromPsoralea corylifoliaand shows several biological activities. Although there have been studies on the biological effects of bakuchicin, its modulation potency of CYP activities has not been previously investigated. Here, we investigated the inhibitory effects of bakuchicin on the activities of CYP isoforms by using a cocktail of probe substrates in pooled human liver microsomes (HLMs) and human recombinantcDNA-expressedCYP. Bakuchicin strongly inhibited CYP1A-mediated phenacetinO-deethylation with an IC50value of 0.43 μM in HLMs. It was confirmed by human recombinantcDNA-expressedCYP1A1 and CYP1A2 with aKivalue of 0.11 μM and 0.32 μM, respectively. A Lineweaver-Burk plot indicated that the inhibition mechanism of bakuchicin was competitive inhibition. Overall, this is the first study to investigate the potential CYP1A1 and CYP1A2 inhibition associated with bakuchicin and to report its competitive inhibitory effects on HLMs.

Development of a novel multiplex electrochemiluminescent-based immunoassay for quantification of human serum IgG against 10 Staphylococcus aureus toxins

2016 ◽  
Vol 430 ◽  
pp. 33-42 ◽  
Author(s):  
Rajan P. Adhikari ◽  
Christian Haudenschild ◽  
Patricia M. Sterba ◽  
Sara Sahandi ◽  
Sven Enterlein ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Human Serum ◽  
Serum Igg

Absolute quantitation of high abundant Fc-glycopeptides from human serum IgG-1

2020 ◽  
Vol 1102 ◽  
pp. 130-139 ◽  
Author(s):  
Cuiyan Cao ◽  
Long Yu ◽  
Dongmei Fu ◽  
Jingli Yuan ◽  
Xinmiao Liang
Keyword(s):  
Human Serum ◽  
Absolute Quantitation ◽  
Serum Igg
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